Fever—An Update

Becker, John H.; Wu, Stephanie

doi:10.7547/1000281

Cited by 9 publications

(2 citation statements)

References 104 publications

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“…8 The administration of antipyretics to children is a common practice supported by most clinicians. 7,9 However, some physicians and researchers argue that fever is a benign condition that can serve a protective function and that it should not be justification for the routine administration of antipyretics. 1,10,11 Mackowiak argues that no experimental evidence exists to support the most basic justifications of antipyretic administration, specifically that reducing fever via antipyretics eliminates the harmful effects of fever or even that harmful effects necessarily accompany fever.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, Lee et al 15 propose that antipyretic treatments given to suppress the febrile response to infection may worsen patient outcomes. Because antipyretic administration is often justified by a desire to diminish the uncomfortable symptoms of fever, 9,12 it is essential that clinicians substantiate the symptoms patients experience during fevers. As Styrt and Sugarman 8 explain: “It is frequently acknowledged that a common reason for antipyretic therapy is ‘symptomatic treatment’ of fever.…”

Section: Introductionmentioning

confidence: 99%

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Beyond Intuition: Patient Fever Symptom Experience

Ames

Peng

Powers

et al. 2013

Journal of Pain and Symptom Management

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Context Fever is an important sign of inflammation recognized by health care practitioners and family caregivers. However, few empirical data obtained directly from patients exist to support many of the long-standing assumptions about the symptoms of fever. Many of the literature-cited symptoms, including chills, diaphoresis, and malaise, have limited scientific bases, yet they often represent a major justification for antipyretic administration. Objectives To describe the patient experience of fever symptoms for the preliminary development of a fever assessment questionnaire. Methods Qualitative interviews were conducted with 28 inpatients, the majority (86%) with cancer diagnoses, who had a recorded temperature of ≥38°C within approximately 12 hours before the interview. A semi-structured interview guide was used to elicit patient fever experiences. Thematic analyses were conducted by three independent research team members, and the data were verified through two rounds of consensus building. Results Eleven themes emerged. The participants reported experiences of feeling cold, weakness, warmth, sweating, nonspecific bodily sensations, gastrointestinal symptoms, headaches, emotional changes, achiness, respiratory symptoms, and vivid dreams/hallucinations. Conclusion Our data not only confirm long-standing symptoms of fever but also suggest new symptoms and a level of variability and complexity not captured by the existing fever literature. Greater knowledge of patients’ fever experiences will guide more accurate assessment of symptoms associated with fever and the impact of antipyretic treatments on patient symptoms in this common condition. Results from this study are contributing to the content validity of a future instrument that will evaluate patient outcomes related to fever interventions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beyond Intuition: Patient Fever Symptom Experience

Ames

Peng

Powers

et al. 2013

Journal of Pain and Symptom Management

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Immunoaffinity capillary electrophoresis: A new versatile tool for determining protein biomarkers in inflammatory processes

Guzman¹,

Phillips

2011

Electrophoresis

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Many diseases caused by inflammatory processes can progress to a chronic state causing deterioration in the quality of life and a poor prognosis for long-term survival. To address inflammatory diseases effectively, early detection and novel therapeutics are required. However, this can be challenging, in part because of the lack of early predictive biomarkers and the limited availability of adequate technologies capable of the identification/characterization of key predictive biomarkers present in biological materials, especially those found at picomolar concentrations and below. This review highlights the need for state-of-the art methodologies, with high-sensitivity and high-throughput capabilities, for determination of multiple biomarkers. Although many new biomarkers have been discovered recently, existing technology has failed to successfully bring this advancement to the patient's bedside. We present an overview of the various advances available today to extend the discovery of predictive biomarkers of inflammatory diseases; in particular, we review the technology of immunoaffinity capillary electrophoresis (IACE), which combines the use of antibodies as highly selective capture agents with the high resolving power of capillary electrophoresis. This two-dimensional hybrid technology permits the quantification and characterization of several protein biomarkers simultaneously, including subtle structural changes such as variants, isoforms, peptide fragments, and post-translational modifications. Furthermore, the results are rapid, sensitive, can be performed at a relatively low cost, without the introduction of false positive or false negative data. The IACE instrumentation can have relevance to medical, pharmaceutical, environmental, military, cultural heritage (authenticity of art work), forensic science, industrial and research fields, and in particular as a point-of-care biomarker analyzer in translational medicine.

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Febrile conditions in rheumatology

Speer¹

2012

Clin Rheumatol

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Fever is not the most frequent symptom in rheumatology; however, its occurrence always draws attention to a severe underlying pathologic process. The rheumatologic assessment of febrile patients usually takes place for three reasons: the patient's fever is associated with known rheumatic disease or musculoskeletal symptoms, or rheumatologic cause is suggested as the underlying cause of fever of unknown origin. The primary task of the rheumatologist is to rule out infections and autoimmune processes. In addition to the musculoskeletal and accompanying symptoms, the information about the course of fever and the observation of the continuity or periodicity of fever provide help to establish the diagnosis. A summarising discourse about this issue is rarely published in this speciality; therefore, we found it important to provide an overview of rheumatological diseases accompanied by fever.

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Fever—An Update

Cited by 9 publications

References 104 publications

Beyond Intuition: Patient Fever Symptom Experience

Beyond Intuition: Patient Fever Symptom Experience

Immunoaffinity capillary electrophoresis: A new versatile tool for determining protein biomarkers in inflammatory processes

Febrile conditions in rheumatology

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