Fetuses and infants with congenital urinary system anomalies: correlation between prenatal ultrasound and postmortem findings

Abstract

The accordance between ultrasound diagnoses and postmortem examinations proved to be satisfactory. The close co-operation between ultrasonographers and perinatal pathologists is mutually beneficial. In addition to complementing prenatal diagnosis, postmortem examination is of vital importance for the quality control of ultrasonography in fetal diagnosis and plays an important role in genetic counseling.

Comparison Between Prenatal and Perinatal Imaging and Foetal Autopsy Results in a Tertiary Care Hospital in South India

“…There is also a concept of 'limited autopsy' with a photograph and radiograph of the foetus that will help for the diagnosis if other examination is not possible. [8] [9] The ultrasonogram correlation with the autopsy findings were done as per the categories described by Isaksen et al [7] Full agreement was obtained in 44.9% of cases in our study. Category 3 and Category 4 together formed 28.5%, which includes findings that were not detected at all in ultrasound or findings that were not confirmed in foetal autopsy.…”

“…A correlation of findings was done with the autopsy findings and ultrasound examination. The correlation of ultrasound and autopsy findings was categorised into groups (categories 1 -4) according to a modification of the method described by Isaksen et al [7] 1. Full agreement between the ultrasound and autopsy findings.…”

“…Ultrasound findings are compared using sensitivity and specificity. Correlation between Ultrasonographic and Autopsy FindingsThe correlation of ultrasound and autopsy findings was categorised into 4 groups according to a modification of the method described by Isaksen et al [7] The findings in each category is given in the …”

Fetal, perinatal, and infant death with congenital renal anomaly

“…EUROCAT, 6 for example, does not register cases delivered before 20 weeks gestation and includes only renal agenesis and cystic disease for urinary tract anomalies. Isaksen and colleagues 7 analysed the postmortem examination findings in 112 fetuses with urinary system anomalies. In their series, 45% of the pregnancies were terminated; in four cases major renal anomalies were not suspected antenatally, and in a further four the renal anomaly was missed, even though anomalies in other systems were ascertained.…”

Sonographic Findings of Fetuses with an Empty Renal Fossa and Normal Amniotic Fluid Volume

“…These malformations constitute 20-30% of all sonographically detected congenital abnormalities. Serious defects of the kidneys or bladder are seen in approximately in 2-3 fetuses per 1,000 ultrasound procedures [1]. Conversely, taking the whole spectrum from minor, clinically irrelevant to severe and even lethal anomalies, these malformations may be present in up to 10% of all births [2].…”