Fetotoxic effects of locoweed (Astragalus lentiginosus) in pregnant goats.

Furlan, Sanja Zuzic; Panter, Kip E.; Pfister, J. A.; Stegelmeier, B. L.

doi:10.1079/9781845932732.0130

Cited by 9 publications

(4 citation statements)

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“…Little work has been done to characterize the effect of other swainsonine-containing plants such as locoweeds in goats. Furlan et al [ 74 ] used a high swainsonine dose of 8 mg/kg BW from Astragalus lentiginosus , and pregnant goats became severely intoxicated in 10 days. Fetal death was observed in all locoweed-treated goats between 10 and 20 days after the beginning of locoweed treatment.…”

Section: Discussionmentioning

confidence: 99%

Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior

Gotardo

Pfister

Raspantini

et al. 2016

Toxins

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Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Twenty-four pregnant goats were randomly allocated into four treatment groups and received the following doses (g/kg BW) of fresh I. carnea: 0 (control group), 1.0 (IC1), 3.0 (IC3), and 5.0 (IC5) from day 27 of gestation until parturition. Dam and kid bonding and behavior were evaluated by several tests, immediately after birth until six weeks of age. Dams from IC3 and IC5 groups spent less time paying attention to the newborn. There was a lack of maternal-infant bonding due to I. carnea intoxication. Kids from treated dams had difficulty in standing, suckling, and in recognizing their mother hours after birth. I. carnea can also compromise the kids’ ability to learn and to retain spatial memory. We suggest that kids from pregnant goats given I. carnea during gestation have significant behavioral alterations and developmental delays that may compromise their survival.

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Section: Discussionmentioning

confidence: 99%

Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior

Gotardo

Pfister

Raspantini

et al. 2016

Toxins

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“…The body weights of the live pups on PND 15 of groups I, II, and III for F0 were higher than those of the F1 generation mice. Locoweed causes embryonic and fetal death, abortions, generalized reproductive dysfunction, and occasional birth defects [29]. In this study, the fetuses underwent autolysis, and the number of live pups on PND 0 for groups I, II, and III was lower than that of group IV for the F0 and F1 generations.…”

Section: Discussionmentioning

confidence: 70%

Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice

Feng

et al. 2016

BioMed Research International

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Swainsonine is the primary toxin in locoweeds. It causes intention tremors, reproductive dysfunction, emaciation, and death. The objective of the present study was to evaluate the potential reproductive and developmental toxicities caused by swainsonine in mice. The treatment groups consisting of three generations of mice were given a range of concentrations of swainsonine by intraperitoneal injection (2.50 mg/kg body weight (BW), 1.20 mg/kg BW, 0.60 mg/kg BW, and 0 mg/kg BW). The 0 mg/kg BW group exhibited significantly fewer estrous cycles and an increased number of estrous ones compared to the 2.50 mg/kg BW, 1.20 mg/kg BW, and 0.60 mg/kg BW groups (P < 0.05). All three generations of mice treated with swainsonine had significantly higher spleen, liver, and kidney indices and significantly lower body weights compared to the 0 mg/kg BW group (P < 0.05). For the first and second generations of treatment group, the copulation indices and the numbers of live pups on postnatal days (PND) 0, 4, and 15 were significantly decreased compared to those of the 0 mg/kg BW group (P < 0.05). The fertility and gestation indices of the treatment group of the first generation were significantly increased compared to the 2.50 mg/kg BW, 1.20 mg/kg BW, and 0.60 mg/kg BW groups of the second generation (P < 0.05). Cumulatively, these results indicate that swainsonine may cause reproductive and developmental toxicities in mice in both parents and offspring.

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“…When present in high concentrations these compounds can be toxic to the animal's metabolism, affecting the nervous, immune, endocrine and reproduction systems. 4,5 In extreme cases if can cause death of animals. 6 In Azorean islands the plants non-conventional with greater relevance are Pittosporum undulatum Vent.…”

Section: Introductionmentioning

confidence: 99%

Effects of non-conventional feed (pittosporum undulatum) in bovine progesterone levels

Nunes¹

2018

JDVAR

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There are several advantages of using non-conventional feed in animal production, reducing the cost of food by using locally available resources. Hedychium gardnerianum and Pittosporum undulatum are invasive plants all over the world, being in the Azores supplied to livestock during periods of lack of food. As these plants produce secondary metabolites, including a diverse assortment of phytochemicals, with this study we understand that excess the consumption of Pittosporum undulatum affects negatively bovine reproductive performance.

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Fetotoxic effects of locoweed (Astragalus lentiginosus) in pregnant goats.

Cited by 9 publications

References 0 publications

Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior

Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior

Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice

Effects of non-conventional feed (pittosporum undulatum) in bovine progesterone levels

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