Fetal ventriculomegaly: Diagnosis, treatment, and future directions

Pisapia, Jared; Sinha, Saurabh; Zarnow, Deborah M.; Johnson, Mark P.; Heuer, Gregory G.

doi:10.1007/s00381-017-3441-y

Cited by 63 publications

(58 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The accuracy of fetal ultrasound reported in the literature differs enormously. The overall accuracy of ultrasound when compared to autopsy is around 77%, while for separate underlying causes accuracy can be as low as 30% and as high as 100% [2,[11][12][13][14][15][16][17][18][19]. The reported variation in accuracy rates is due to the heterogeneity of the underlying causes discussed in these papers, from acquired infections to genetic predispositions and disruptions in various brain structures.…”

Section: Discussionmentioning

confidence: 99%

“…In case of VM, which is an ultrasound sign rather than a disease in itself, diagnosis of underlying pathology in utero is challenging both before and after 24 weeks' GA. Counseling on the prognosis of VM prior to 24 weeks' gestation is hampered by the fact that progressive dilatation in the third trimester cannot reliably be predicted, while this is the only significant predictor for postnatal major brain abnormalities in cases of isolated VM. [2,14,24].…”

Section: Discussionmentioning

confidence: 99%

“…arterio-venous malformation; agenesis of the corpus callosum), or acquired malformations (e.g. infection or hemorrhage) [2].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Accuracy of diagnosis and counseling of fetal brain anomalies prior to 24 weeks of gestational age

Snoek

Albers

Mulder

et al. 2017

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

Despite the challenges of early gestation, accuracy in diagnosing and counseling fetal brain anomalies before 24 weeks' GA was high. Prenatal genetic testing is a valuable diagnostic tool and should be offered to all women with fetal brain anomalies. Considering the many different types of anomalies and diverse etiologies, a multidisciplinary approach is essential for counseling on postnatal outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Accuracy of diagnosis and counseling of fetal brain anomalies prior to 24 weeks of gestational age

Snoek

Albers

Mulder

et al. 2017

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

show abstract

“…Other CNS anomalies included the following: VMG, defined by a ventricular diameter greater than 10 mm, in six cases (100%) and short corpus callosum, defined smaller than the fifth percentile, in three cases.…”

Section: Resultsmentioning

confidence: 99%

Fetal MRI findings in a retrospective cohort of 26 cases of prenatally diagnosed CHARGE syndrome individuals

et al. 2019

View full text Add to dashboard Cite

“CHARGE syndrome” (CS) is a multifaceted syndrome associated with a poor prognosis. The prenatal diagnosis remains challenging especially as the fetal anomalies that may evoke suspicion of CS are not comprehensively described. Objective This study aims to identify the anomalies in MRI with suspected CHARGE syndrome and to propose a possible standardization in the image‐based prenatal diagnosis of CS. Methods This was a retrospective study of 26 fetuses who underwent MRI and had a confirmed diagnosis of CS, as proven by histopathological and/or neonatal examinations and/or the presence of the CHD7 gene mutation. Results The three most frequent MRI anomalies confirmed at histopathological and/or neonatal examinations were arhinencephaly in 100% (26 of 26), dysplasia of the semicircular canals agenesis (SCA) in 100% (24 of 24), and posterior fossa anomalies in 100% (22 of 22). Our study also revealed short petrous bones with a particular triangular shape in 24 of 24 cases of SCA. Other relevant findings included external ear anomalies in 36% (9 of 25), cleft lip and palate (9 of 9), ventriculomegaly (VMG) (6 of 6), short corpus callosum (3 of 3), and ocular asymmetry in 36.6% (4 of 11). Conclusion Our study emphasizes the interest of fetal MRI in the diagnosis of CS with an adapted knowledge of semiology.

show abstract

“…al. [14] revealed that head circumference (HC) remains normal in most cases of VM. Only in cases with severe hydrocephaly causing abnormal intracranial pressure, resulting in increased head circumference (HC) above 400 mm, may qualify for elective caesarean section due to the high risk of obstetrical complications; however, there were no such cases in our study group.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of prenatally diagnosed ventriculomegaly — 10 years of Polish tertiary centre experience

et al. 2019

View full text Add to dashboard Cite

Objectives:To estimate the prevalence, associated anomalies, and postnatal outcomes in infants prenatally diagnosed with ventriculomegaly.Material and methods: All cases of ventriculomegaly that were examined and treated by the 1st Department of Obstetrics and Gynecology, at the Medical University of Warsaw, from August 2007 until November 2017 were included in this study. Ultrasound data, and information on perinatal outcomes and long-term postnatal follow up were retrospectively collected by a standardised telephone survey. Ventriculomegaly was diagnosed when the atrial width of the lateral ventricles was ≥ 10 mm. The cases analyzed were divided into two subgroups: isolated ventriculomegaly (IVM) and non-isolated ventriculomegaly (NIVM). Neurodevelopmental complications were differentiated as either moderate or severe and were compared within each group and between groups.Results: There were 118 cases of prenatally diagnosed ventriculomegaly. Complete follow up records were collected for 54 cases (45.8%). IVM was diagnosed in 29/54 (53.7%) cases, while NIVM was diagnosed in the remaining 25 (46.3%). The mean ventricular width for IVM was 16.93 mm (range 10.0 mm-73.0 mm) and 14.08 mm (range 9.0 mm-27.1 mm) for NIVM (p = 0.28). The mean gestational age at delivery for the IVM cases was 36 + 4 weeks and in the NIVM group 33 + 4 weeks (p = 0.022). Mild VM (10-12 mm) was diagnosed in 22/54 cases (40.7%), moderate VM (13-15 mm) in 12/54 (22.3%) and severe (≥ 15 mm) in 20/54 (37%). Among the infants with IVM the rate of severe medical complications was 29.6% (8/28) and for NIVM 667% (8/12) (p = 0.041). Less severe medical conditions affected 6/28 of the infants with IVM (21.4%) vs 9/12 NIVM cases (75%) (p = 0.012). Conclusions:In terms of prenatal diagnosis, treatment of ventriculomegaly remains challenging due to a lack of specific prognostic factors and the significant risk of neurodevelopmental disorders. Nevertheless, isolated ventriculomegaly has significantly better long-term outcomes compared with non-isolated ventriculomegaly. In our material, the rate of severe neurodevelopmental disorders in the non-isolated ventriculomegaly cases was associated with a 52% rate of adverse perinatal outcomes. On the other hand, less severe medical conditions occurred in 21.4% of the infants with IVM and in 75% of the NIVM cases. Furthermore, obstetrical data suggest that the risks of premature delivery and caesarean section are significantly higher in cases of non-isolated ventriculomegaly.

show abstract

Fetal ventriculomegaly: Diagnosis, treatment, and future directions

Cited by 63 publications

References 66 publications

Accuracy of diagnosis and counseling of fetal brain anomalies prior to 24 weeks of gestational age

Accuracy of diagnosis and counseling of fetal brain anomalies prior to 24 weeks of gestational age

Fetal MRI findings in a retrospective cohort of 26 cases of prenatally diagnosed CHARGE syndrome individuals

Long-term outcomes of prenatally diagnosed ventriculomegaly — 10 years of Polish tertiary centre experience

Contact Info

Product

Resources

About