Fetal Ventricular Diastolic Filling Characteristics in a Primate Model: The Role of Fetal Heart Rate and Pulmonary Vascular Impedance

Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development.

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Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Hirsch

et al. 2018

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Fetal Ventricular Diastolic Filling Characteristics in a Primate Model: The Role of Fetal Heart Rate and Pulmonary Vascular Impedance

Abstract: Fetal ventricular diastolic filling characteristics are related to FHR but not to pulmonary vascular impedance.

Cited by 1 publication

References 20 publications

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

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