Fetal varicella syndrome

Alkalay, Arie L.; Pomerance, Jeffrey J.; Rimoin, David L.

doi:10.1016/s0022-3476(87)80447-x

Cited by 157 publications

(22 citation statements)

References 26 publications

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“…Proof of intrauterine infections, irrespective of whether or not CVS develops, can be deduced from the detection of VZV DNA in the fetus or neonate, the presence of specific IgM in fetal or cord blood, the persistence of specific IgG beyond 7 months of age and the development of HZ during infancy. 30,33 Nearly 20% of infants with intrauterine acquisition of VZV infection develop neonatal or infantile HZ, which is usually uncomplicated. 21 Although fetal serological detection of specific IgM is useful in confirming evidence of intrauterine infection, in general, serology has a low sensitivity and is therefore unreliable, and is not recommended for the diagnosis of CVS caused by maternal chickenpox.…”

Section: Diagnosis Of Cvsmentioning

confidence: 99%

Varicella-zoster virus (chickenpox) infection in pregnancy

Lamont

Sobel

Carrington³

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

152

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Congenital varicella syndrome, maternal varicella zoster virus pneumonia and neonatal varicella infection are associated with serious feto-maternal morbidity and not infrequently with mortality. Vaccination against Varicella zoster virus can prevent the disease and outbreak control limits the exposure of pregnant women to the infectious agent. Maternal varicella zoster immune globulin (VZIG) administration before rash development, with or without antivirals medications can modify progression of the disease.

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Section: Diagnosis Of Cvsmentioning

confidence: 99%

Varicella-zoster virus (chickenpox) infection in pregnancy

Lamont

Sobel

Carrington³

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

152

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“…The fetal varicella syndrome is a congenital malformation complex that may occur after first and early second trimester (wks 8-20) maternal varicella infection (25). Common features include intrauterine growth retardation, prematurity, cicatricial lesions in a dermatomal distribution, limb paresis and hypoplasia, chorioretinitis, and cataracts.…”

Section: Varicella-zoster Infections In Pregnancymentioning

confidence: 99%

Oral Acyclovir Therapy for Varicella and Zoster Infections in Pediatric and Pregnant Patients: A Brief Review

Rothe

Feder

Grant‐Kels

1991

Pediatric Dermatology

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Oral acyclovir recently was approved for the treatment of herpes zoster and has been shown to be effective in the treatment of varicella. Studies of the use of high-dose oral acyclovir in the management of varicella-zoster infections in immunocompetent pediatric patients are reviewed. Guidelines are provided for the drug's use in immunocompetent children and adolescents, pregnant patients, and pediatric atopic patients receiving systemic steroids.

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“…The first case of congenital anomalies because of early pregnancy varicella was reported in 1947 (3). Since then only scattered reports have been published on a fetal varicella syndrome and not until recently were specific criteria proposed for documenting the association between early pregnancy varicella and associated congenital anomalies (4). We describe an infant born with several characteristics of the fetal varicella syndrome and IgM antibodies to VZ virus but in whom no skin lesions were present.…”

mentioning

confidence: 92%