Fetal varicella-herpes zoster syndrome in early pregnancy: ultrasonographic and morphological correlation

Petignat, Patrick; Vial, Yvan; Laurini, Richard N.; Hohlfeld, P.

doi:10.1002/1097-0223(200102)21:2<121::aid-pd996>3.0.co;2-p

Cited by 38 publications

(14 citation statements)

References 7 publications

(12 reference statements)

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“…The abnormalities of the fetal varicella syndrome appear to be secondary to denervation of fetal structures as a result of the neurotropic nature of the virus and exposure during fetal stage [6].…”

Section: Discussionmentioning

confidence: 99%

“…Prenatal diagnosis is not easy and detailed ultrasound is not able to detect all defects (limb deformity, microcephaly, hydrocephalus, polyhydramnios, soft tissue calcification and intrauterine growth retard) [6]. At least 5 weeks interval between imaging and clinical presentation in the mother is advised to detect deformities in the fetus [6].…”

Section: Discussionmentioning

confidence: 99%

“…At least 5 weeks interval between imaging and clinical presentation in the mother is advised to detect deformities in the fetus [6].…”

Section: Discussionmentioning

confidence: 99%

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Unilateral laryngeal paralysis in a newborn with congenital varicella syndrome

Rizzardi

Tagliaferro

Snijders

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unilateral laryngeal paralysis in a newborn with congenital varicella syndrome

Rizzardi

Tagliaferro

Snijders

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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“…Ultrasonography is particularly useful for detecting fetal malformations (limb deformity, microcephaly, hydrocephalus, polydramnios, soft tissue calcification, and intra-uterine growth restriction) [90,180,495,496] , and is recommended after 16-22 wk of gestation or five weeks after infection [16,187,493,497] . It is not sensitive enough to detect congenital defects before the fourth week [16,493,497] .…”

Section: Prenatal Infection and The Diagnosis Of Cvsmentioning

confidence: 99%

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

Paschale

Clerici

2016

WJV

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Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection. A Microbiology laboratory can help in the diagnosis and management of mother-child infection at four main times: (1) when a pregnant woman has been exposed to varicella or herpes zoster, a prompt search for specific antibodies can determine whether she is susceptible to, or protected against infection; (2) when a pregnant woman develops clinical symptoms consistent with varicella, the diagnosis is usually clinical, but a laboratory can be crucial if the symptoms are doubtful or otherwise unclear (atypical patterns in immunocompromised subjects, patients with post-vaccination varicella, or subjects who have received immunoglobulins), or if there is a need for a differential diagnosis between varicella and other types of dermatoses with vesicle formation; (3) when a prenatal diagnosis of uterine infection is required in order to detect cases of congenital varicella syndrome after the onset of varicella in the mother; and (4) when the baby is born and it is necessary to confirm a diagnosis of varicella (and its complications), make a differential diagnosis between varicella and other diseases with similar symptoms, or confirm a causal relationship between maternal varicella and malformations in a newborn. Core tip: Although varicella during pregnancy is infrequent and congenital varicella syndrome (CVS) is rare, every available means should be used to prevent and diagnose them. Microbiology laboratories can be crucial in these situations: Evaluating a mother's immune status with sensitive and specific tests for the detection of antibodies; allowing a rapid diagnosis with molecular biology tests when a clinical manifestation may be due to different etiologies; following pregnant women with varicella for the prenatal diagnosis of CVS with close collaboration between molecular biology investigators and specialists in imaging diagnostics.De Paschale M, Clerici P. Microbiology laboratory and the management of mother-child varicella-zoster virus infection. World

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“…Successful use of ultrasound as a diagnostic tool to identify this syndrome prenatally has also been reported in cases with evidence of widespread infection [273][274][275][276]. Three published reports indicate, however, that ultrasound is not infallible.…”

Section: Fetal Malformations and Management Of Pregnant Women With Vamentioning

confidence: 99%

Chickenpox, Measles, and Mumps

Gershon¹

2011

Infectious Diseases of the Fetus and Newborn

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Fetal varicella-herpes zoster syndrome in early pregnancy: ultrasonographic and morphological correlation

Cited by 38 publications

References 7 publications

Unilateral laryngeal paralysis in a newborn with congenital varicella syndrome

Unilateral laryngeal paralysis in a newborn with congenital varicella syndrome

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

Chickenpox, Measles, and Mumps

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