Fetal Tissue Biopsy: Techniques and Indications

Rodeck, C. H.; Nicolaides, Kypros H.

doi:10.1159/000262232

Cited by 8 publications

(4 citation statements)

References 26 publications

(29 reference statements)

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“…In 1986, the same group described an US-guided biopsy of an intrapulmonary mass, using a 16G needle. A congenital pulmonary adenomatoid malformation (CPAM) of the lung was diagnosed on histological examination and an abortion was performed [2] .…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of a Liver Mass by Tru-Cut® Biopsy

et al. 2022

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A 32 year old, gravida 2 para 1 at 33 week’s gestation, was referred for a third opinion regarding a large fetal liver mass. The couple sought approval for a termination of pregnancy, following a differential diagnosis of hepatoblastoma. A specialised ultrasound (US) and fetal magnetic resonance imaging (f-MRI) were repeated in our unit and the results were consistent with a diagnosis of haemangioma. A Tru-Cut® (Meritmedical, Utah, USA) liver biopsy was performed confirming a benign haemangioma and the couple opted to continue with the pregnancy.

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Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of a Liver Mass by Tru-Cut® Biopsy

et al. 2022

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“…An electron microscope study of the fetal skin sample is required to confirm the diagnosis. The procedure is safe and in a study of 52-skin biopsy by Rodeck no complications were recorded [39].…”

Section: Technique Of Fetal Skin Biopsymentioning

confidence: 91%

Developmental Genetics and Preimplantation Genetic Diagnosis

Chakrabarti¹,

Sharma²

2018

Genetic Diversity and Disease Susceptibility

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The genetic code information programs the embryogenesis. In this chapter the three phases of prenatal development the pre-embryonic, the embryonic and the fetal are elaborated. The role played by transforming growth factor beta related genes in the growth and differentiation of early embryo will be described. The implications of Fibroblast growth factor gene in binding heparin its effect on cell survival and mitogenic pathways is discussed. The orchestrated symphony of Sonic Hedgehog genes in early human embryo development is elaborated. The Homeobox genes (Hox gene) and their role in early human embryogenesis are described. The different tests available for prenatal genetic testing are briefly described. Preimplantation genetic diagnostic procedures are indispensable in clinical embryology. The microsurgical techniques of the Polar body biopsy, Blastomere biopsy and Blastocyst biopsy are discussed at the end of the chapter. A diagrammatic representation of individuals and relationships in clinical genetics is described. A brief description of procedures of invasive fetal tests for collecting the fetal tissue is also discussed.

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“…It has been reported that fetal skin (Golbus et al, 1980), fetal liver (Rodeck et al, 1982), and fetal muscle (Evans et al,199 1) can be useful for early prenatal diagnosis of a number of fetal diseases. Rodeck and Nicolaides (1986) briefly reported on fetal lung biopsy in a case of CCAML. They obtained their specimen by aspiration biopsy.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of congenital cystic adenomatoid malformation of the lung by fetal lung biopsy

et al. 1994

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A case of type III congenital cystic adenomatoid malformation of the lung was successfully diagnosed prenatally by fetal lung biopsy. We performed this procedure at 22 weeks of gestation, using a biopsy gun system under ultrasound guidance. The pregnancy was undisturbed by the procedure but as the condition was incompatible with life, an abortion was performed. The diagnosis was confirmed at post-mortem examination. Fetal lung biopsy appears to be a useful method for prenatal diagnosis of fetal lung disorders.

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Fetal Tissue Biopsy: Techniques and Indications

Abstract: A considerable variety of invasive intrauterine procedures has been developed in the last 15 years. This article describes techniques for obtaining fetal blood, skin, liver, tumour specimens and chorionic villi, and discusses their indications and risks.

Cited by 8 publications

References 26 publications

Prenatal Diagnosis of a Liver Mass by Tru-Cut® Biopsy

Prenatal Diagnosis of a Liver Mass by Tru-Cut® Biopsy

Developmental Genetics and Preimplantation Genetic Diagnosis

Prenatal diagnosis of congenital cystic adenomatoid malformation of the lung by fetal lung biopsy

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