Fetal Survival After Prednisone Suppression of Maternal Lupus-Anticoagulant

Lubbe, Welma; Palmer, Sara J.; Butler, W. S.; Liggins, G. C.

doi:10.1016/s0140-6736(83)92141-4

Cited by 415 publications

(115 citation statements)

References 12 publications

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“…Moreover, the natural history of these antibodies is unknown. Prednisone treatment in women who have recurrent spontaneous abortions has resulted both in a decrease in ACL antibodies (although not always to normal levels) and a correction of LA activity with successful completion of pregnancy (11,12). For the most part, recurrent thrombosis in patients with ACL antibodies has been treated with anticoagulants.…”

Section: (174)mentioning

confidence: 99%

Anticardiolipin antibodies in patients with rheumatic diseases

Fort

Cowchock

Abruzzo

et al. 1987

Arthritis & Rheumatism

122

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Section: (174)mentioning

confidence: 99%

Anticardiolipin antibodies in patients with rheumatic diseases

Fort

Cowchock

Abruzzo

et al. 1987

Arthritis & Rheumatism

122

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“…84 - 85 Steroids have failed to prevent systemic thrombosis 41 and are probably not effective in preventing stroke 78 -80 in patients with SLE or LA. The risks of steroid therapy at the levels proven to be effective against spontaneous abortion (40 mg/day) may be acceptable for the duration of a pregnancy, but not for the years required for stroke prevention.…”

mentioning

confidence: 99%

Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus.

Futrell

Millikan

1989

Stroke

181

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We retrospectively and prospectively reviewed the incidence of stroke in 105 patients with systemic lupus erythematosus (SLE). Stroke occurred in 14 (15%) of 91 consecutive patients with documented SLE; nine (64%) of the 14 had multiple cerebral infarcts. Factors associated with stroke and the frequency of stroke were systemic thrombosis (30%), elevated partial thromboplastin time (36%), spontaneous abortion (50%), age over 60 years (57%), transient ischemic attacks (57%), previous stroke (64%), and cardiac valvular disease (86%).

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“…Early therapy has led to normal pregnancies in several reported cases. 3,11,13 Patients with lupus anticoagulant and anticardiolipin antibodies who have had previous unsuccessful pregnancy have gone on to deliver healthy infants following treatment with prednisolone (40-60 mg/day) and aspirin (75-80 mg/day), started as soon as pregnancy was detected. 12 Prednisolone usually suppresses the production or activity of lupus anticoagulant and cardiolipin antibody.…”

Section: Discussionmentioning

confidence: 99%