Fetal Splenic Artery Peak Velocity (SPA-PSV) at Mid-Pregnancy as a Predictor of Hb Bart’s Disease

Tongsong, Theera; Piyamongkol, Wirawit; Tongprasert, Fuanglada; Srisupundit, Kasemsri; Luewan, Suchaya

doi:10.1055/s-0029-1245537

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Apart from the cardiothoracic ratio, placental thickness, and middle cerebral artery PSV, predictive values for detection of fetuses with α‐thalassemia major by other markers, including liver length (Figure 4), 63 cardiac circumference derived by spatiotemporal image correlation, 65 splenic artery Doppler PSV, 66 and splenic circumference, 67 were also reported (Table 4). Despite the fact that their diagnostic effectiveness was not as excellent as that of the cardiothoracic ratio and that they should not be used as primary screening tools, these markers are still useful for identifying fetuses with α‐thalassemia major.…”

Section: Other Sonographic Markersmentioning

confidence: 99%

Sonographic Markers of Fetal α‐Thalassemia Major

Zhou

Zhang

et al. 2015

J of Ultrasound Medicine

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α‐Thalassemia prevails in Southeast Asia, where α‐thalassemia major is a lethal type. Sonography is a helpful and cost‐effective screening tool for detecting α‐thalassemia major fetuses. The cardiothoracic ratio, placental thickness, and middle cerebral artery peak systolic velocity are most used in clinical practice. These sensitive markers are helpful for evaluation of the hemodynamic status and cardiovascular function of the affected fetuses. They can predict fetal α‐thalassemia major and assess the efficacy of treatment noninvasively; therefore, the medical costs as well as the possibility of fetal loss caused by invasive procedures can be reduced. Other potentially useful sonographic markers need further studies, although previous preliminary research suggests their usefulness. This article will review those sonographic markers.

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Section: Other Sonographic Markersmentioning

confidence: 99%

Sonographic Markers of Fetal α‐Thalassemia Major

Zhou

Zhang

et al. 2015

J of Ultrasound Medicine

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“…Additionally, several other sonographic markers can also support the diagnosis of fetal Hb Bart’s disease, including nuchal translucency, heart circumference, liver length, splenic circumference, and splenic artery peak systolic velocity [ 49 , 54 , 55 , 56 , 57 ]. The performance of sonographic markers is shown in Table 1 .…”

Section: Bart’s Hydrops Fetalis: Clinical Perspectives and Current Di...mentioning

confidence: 99%

Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart’s Disease

Chaemsaithong

Luewan

Taweevisit

et al. 2023

IJMS

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Extracellular vesicles (EVs) are nano-scaled vesicles released from all cell types into extracellular fluids and specifically contain signature molecules of the original cells and tissues, including the placenta. Placenta-derived EVs can be detected in maternal circulation at as early as six weeks of gestation, and their release can be triggered by the oxygen level and glucose concentration. Placental-associated complications such as preeclampsia, fetal growth restriction, and gestational diabetes have alterations in placenta-derived EVs in maternal plasma, and this can be used as a liquid biopsy for the diagnosis, prediction, and monitoring of such pregnancy complications. Alpha-thalassemia major (“homozygous alpha-thalassemia-1”) or hemoglobin Bart’s disease is the most severe form of thalassemia disease, and this condition is lethal for the fetus. Women with Bart’s hydrops fetalis demonstrate signs of placental hypoxia and placentomegaly, thereby placenta-derived EVs provide an opportunity for a non-invasive liquid biopsy of this lethal condition. In this article, we introduced clinical features and current diagnostic markers of Bart’s hydrops fetalis, extensively summarize the characteristics and biology of placenta-derived EVs, and discuss the challenges and opportunities of placenta-derived EVs as part of diagnostic tests for placental complications focusing on Bart’s hydrop fetalis.

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“…Early detection and termination of pregnancy can prevent its late serious complications such as severe preeclampsia, dystocia, and postpartum hemorrhage secondary to huge placenta. Prenatal ultrasound plays an important role in the early detection of the affected fetuses, although invasive diagnosis may be required for confirmation. Cardiomegaly, increased peak systolic velocity of the middle cerebral artery, and increased placental thickness are helpful in early detection of anemia and often precede the development of hydrops.…”

Section: Introductionmentioning

confidence: 99%

Fetal septum primum excursion (SPE) and septum primum excursion index (SPEI) as sonomarkers of fetal anemia: using hemoglobin Bart's fetuses as a study model

et al. 2016

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Fetal Splenic Artery Peak Velocity (SPA-PSV) at Mid-Pregnancy as a Predictor of Hb Bart’s Disease

Abstract: SPA-PSV assessment at mid-pregnancy may be used as an adjunct method to identify fetuses with Hb Bart's disease with high, but not perfect, accuracy and may reduce the risk from unnecessary cordocentesis in some fetuses.

Cited by 7 publications

References 15 publications

Sonographic Markers of Fetal α‐Thalassemia Major

Sonographic Markers of Fetal α‐Thalassemia Major

Placenta-Derived Extracellular Vesicles in Pregnancy Complications and Prospects on a Liquid Biopsy for Hemoglobin Bart’s Disease

Fetal septum primum excursion (SPE) and septum primum excursion index (SPEI) as sonomarkers of fetal anemia: using hemoglobin Bart's fetuses as a study model

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