Fetal Sex and Maternal Asthma Control in Pregnancy

Bakhireva, Ludmila N.; Schatz, Michael; Jones, Kenneth Lyons; Tucker, Carey M.; Slymen, Donald J.; Klonoff-Cohen, Hillary; Gresham, Louise S.; Johnson, Diana; Chambers, Christina D.; Quinn, Declan; Vogt, Deborah R; Kao, Kelly; Lavigne, Sharon Voyer; Brochu, Joanne; Buehler, Bruce A.; Conover, Elizabeth; Ormond, Kelly E.; Chou, Chin Cheng; Johnson, Yvette R.; Swerc, S.; Braddock, Stephen R.; Slusher, Paula; Robinson, Luther K.; Gangell, S.; Koren, Gideon; Morreti, M.; Wolfe, L. S.; Carey, John C.; Robertson, Jennifer; Polifka, Janine E.; Rudy, Edwina

doi:10.1080/02770900801971826

Cited by 41 publications

(27 citation statements)

References 25 publications

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“…One explanation is possible maturational delay in male fetuses compared to females (Buss et al 2009), or different growth strategies, with female fetuses limiting growth in benefit of maintaining resource reserves (Clifton 2010). Different immune function in women carrying a female fetus has also been described, showing women carrying female fetuses have greater stimulated production of interleukin(L)-6, tumor necrosis factor(TNF)-α and IL-1-β (Mitchell et al 2017) and greater susceptibility to asthma exacerbations (Bakhireva et al 2008). These findings may contribute to the growing body of literature investigating sexual dimorphisms in pregnancy outcomes, and imply that taking fetal sex into account might be important when determining obstetric risks.…”

Section: Biological Factorsmentioning

confidence: 99%

Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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Please cite this article as: Bleker, Laura S., Roseboom, Tessa J., Vrijkotte, Tanja G., Reynolds, Rebecca M., de Rooij, Susanne R., Determinants of Cortisol During Pregnancy − the ABCD Cohort.Psychoneuroendocrinology http://dx.doi.org/10. 1016/j.psyneuen.2017.05.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy. Methods:We used data from 3039 women from the Amsterdam Born Children and their Development-study cohort. Serum cortisol was measured in blood, collected at the first prenatal visit, at different gestational ages (median=91 days, range=40-256 days), and at various time points during the day (median=11:45h, range=08:00 -18:30h). We assessed associations between maternal serum cortisol in pregnancy and biological factors, lifestyle factors and stress factors, including depression, anxiety, pregnancy-related anxiety, work stress, parenting stress and fatigue. Results:In multivariable analysis, variables that were associated with higher cortisol levels in pregnancy were lower maternal age [1.5 nmol/l, 95%CI (0.6 to 2. Conclusions: Our data suggest that maternal cortisol during pregnancy is mainly affected by biological and lifestyle factors, but not by psychosocial factors. We suggest that psychosocial stress in Laura S. Bleker 3 pregnancy might program the fetus through other mechanisms than through altering maternal cortisol levels.

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Section: Biological Factorsmentioning

confidence: 99%

Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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“…Female sex is associated with higher maternal circulation of monocytes and upregulation of maternal inflammatory pathways. 58 The mechanisms through which sex hormones influence asthma and the immunological characteristics of pregnancy at the maternal-fetal interface remain obscure, and new studies are needed in order to increase our understanding of and ability to manage asthmatic women.…”

Section: Pregnancy and Asthmamentioning

confidence: 99%

“…Maternal asthma is associated with an increased risk of both maternal and fetal adverse perinatal outcomes, 58 such that 20%-30% of women with asthma experience exacerbations that require medical intervention during pregnancy. 43 There is also evidence of an increased risk of maternal mortality among some asthmatic women.…”

Section: Pregnancy and Asthmamentioning

confidence: 99%

Association between asthma and female sex hormones

Baldaçara

Silva

2017

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: The relationship between sex hormones and asthma has been evaluated in several studies. The aim of this review article was to investigate the association between asthma and female sex hormones, under different conditions (premenstrual asthma, use of oral contraceptives, menopause, hormone replacement therapy and pregnancy). DESIGN AND SETTING: Narrative review of the medical literature, Universidade Federal do Tocantins (UFT) and Universidade Federal de São Paulo (Unifesp). METHODS:We searched the CAPES journal portal, a Brazilian platform that provides access to articles in the MEDLINE, PubMed, SciELO, and LILACS databases. The following keywords were used based on Medical Subject Headings: asthma, sex hormones, women and use of oral contraceptives. RESULTS:The associations between sex hormones and asthma remain obscure. In adults, asthma is more common in women than in men. In addition, mortality due to asthma is significantly higher among females. The immune system is influenced by sex hormones: either because progesterone stimulates progesterone-induced blocking factor and Th2 cytokines or because contraceptives derived from progesterone and estrogen stimulate the transcription factor GATA-3. CONCLUSIONS:The associations between asthma and female sex hormones remain obscure. We speculate that estrogen fluctuations are responsible for asthma exacerbations that occur in women. Because of the anti-inflammatory action of estrogen, it decreases TNF-α production, interferon-γ expression and NK cell activity. We suggest that further studies that highlight the underlying physiopathological mechanisms contributing towards these interactions should be conducted. RESUMO CONTEXTO E OBJETIVO:A relação entre os hormônios sexuais e a asma tem sido investigada em diversos estudos. Esta revisão tem como objetivo descrever a relação entre hormônios sexuais (endógenos e exó-genos) e a inflamação nas vias aéreas, especialmente na asma, em eventos diferentes (na asma pré-menstrual, durante o uso de anticoncepcionais, na menopausa, no uso de terapia hormonal e na gestação). TIPO DE ESTUDO E LOCAL:Revisão narrativa da literatura médica, Universidade Federal do Tocantins (UFT) e Universidade Federal de São Paulo (Unifesp). MÉTODO: Pesquisamos o Portal de Periódicos Capes, uma plataforma brasileira que fornece acesso a artigos nas bases de dados MEDLINE, PubMed, SciELO e LILACS. Os descritores utilizados foram asma, hormônios sexuais, mulheres e uso de anticoncepcionais, com base no "Medical Subject Headings". RESULTADOS: As associações entre hormônios sexuais e asma ainda permanecem obscuras. Em adultos, a asma é mais frequente em mulheres do que em homens. Além disso, a mortalidade por asma é significativamente maior no sexo feminino, destacando-se que o sistema imunológico sofre influência de hormônios sexuais, seja porque a progesterona estimula o fator bloqueador induzido pela progesterona e citocinas Th2 ou porque contraceptivos derivados de progesterona e estrógeno estimulam o fator de transcriç...

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“…In the most recent population-based prospective cohort study, peak expiratory flow variability was also greater in asthmatic women pregnant with a female fetus (relative to those with a male fetus) [15], with indirect evidence that this may be mediated by noneosinophilic pathways [16].…”

Section: Affect Of Fetal Sex On Maternal Asthmamentioning

confidence: 97%