Fetal Rights

Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

“…: 160.5 °C, IR (KBr, νmax, cm -1 ): 3351, 3215, 3014, 2998, 1762, 1616, 1584, 1485, 1371, 1143, 1016, 966, 13 C NMR (100 MHz, CDCl3) δ 172. 8, 163.9, 143.6, 140.2, 138.6, 129.7.7, 128.3, 128.1, 127.6, 125.9, 113.4, 87.6, 62.8, 61.3, 41.5, 19.3 5.20;N,6.57;S,7.52;Found C,61.94;H,5.17;N,6.54;S,7. 165.1 °C, IR (KBr, νmax, cm -1 ): 3331,3218,3017,2982,1760,1616,1584,1485,1317,1051,1016,967 8, 163.6, 143.5, 138.7, 138.1, 133.6, 131.4, 129.1, 128.6, 128.2, 113.45, 87.2, 62.7, 61.5, 41.7, 19.2, 14. 3 °C, 3344, 3201, 3005, 1769, 1626, 1614, 1580, 1445, 1312, 1148, 1011, 965, 823, 764; 1 3, 163.7, 143.6, 139.1, 138.6, 133.6, 131.4, 129.9, 129.7, 128.1, 120.4, 114.6, 87.6, 62.5, 61.6, 41.2, 19.4, 14. , IR (KBr, νmax, cm -1 ): 3347, 3212, 3005, 1761, 1621, 1580, 1484, 1325, 1141, 1026, 954, 827, 13 C NMR (100 MHz, CDCl3) δ 172. 3, 164.1, 143.6, 138.9, 137.2, 135.6, 133.7, 129.7, 128.9, 128.3, 127.6, 113.4, 87.3, 62.8, 61.5, 41.6, 21.4, 19.3, 14. 6, 164.1, 157.7, 143.8, 138.9, 133.6, 132.5, 16+29.7, 128.6, 128.3, 114.2, 113.2, 87.4, 62.6, 61.3, 55.8, 41.7, 19.4 6, 163.7, 146.2, 145.1, 143.8, 138.9, 133.6, 129.6, 128.4, 128.1, 123.8, 128.1, 123.8, 113.4, 87.2, 62.7, 61.6, 41.8, 19.4 xylate (6g): Light yellow colour crystalline solid; Yield 88 %, m.p.…”

“…These are widely used as antimicrobial agents, antidiabetic agents, diuretics, anticonvulsants, antiretroviral and Hepatitis-C antiviral agents. Several researches revealed that the broad spectrum antimicrobial activity of sulfone containing heterocycles entities [2][3][4][5][6][7][8][9][10] Recently, Kudruavtsev et al [11] reported that the sulfone bearing pyrrolidine derivatives inhibits Staphylococcus aureus sortase SrtA isoform, irreversibly by modification of enzyme cys 184.…”