Fetal Responses to Acoustic Stimuli

Tanaka, Yasuto; Arayama, T

doi:10.1159/000274903

Cited by 8 publications

(8 citation statements)

References 3 publications

(3 reference statements)

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“…Conversely, CD15 immunoreactivity disappeared with the formation of stabilized contacts when visual plasticity ended and physiological parameters indicated established visual function. With respect to the inferior colliculus, the period of (discrete) signs of heterogeneity of CD15 expression precedes the time from which somatic and visceral responses have been provoked by auditory stimulation of human fetuses (Fleischer, 1955;Tanaka and Arayama, 1969;Grimwalde et al, 1971;Goodlin and Schmidt, 1972;Berkson et al, 1974;Birnholtz, 1983).…”

Section: Comparison Between the Chronology Of Known Developmental Evementioning

confidence: 99%

“…6, some data regarding parameters of functional maturation of the auditory system are collected. The development of visceral and somatomotor responses that can be registered after abdominal acoustic stimulation depends on the frequencies applied (Fleischer, 1955;Tanaka and Arayama, 1969;Grimwalde et al, 1971;Goodlin and Schmidt, 1972;Berkson et al, 1974;Birnholtz, 1983). Investigations of behavioral responses to pure tone stimuli showed that the first response can be observed at 19 weeks and that, at about 27 weeks, almost all fetuses respond to frequencies up to 1,000 Hz (Hepper and Shahidullah, 1994).…”

Section: Phases Of Intense Neuropil Labeling and (Putative Establishmmentioning

confidence: 99%

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Transient CD15 expression reflects stages of differentiation and maturation in the human subcortical central auditory pathway

1999

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The expression of the terminal saccharide determinant CD15 (3[a1-3]-fucosyl-N-acetyl-lactosamine) was evaluated in the central auditory system of the human developing brain by using monoclonal antibodies against this epitope. CD15 immunoreactivity was first observed in the ventral cochlear nucleus at 10 weeks of gestation, whereas the dorsal cochlear nucleus became positive from 13 weeks of gestation. In both nuclei, the intensity of immunoreactivity increased until 16 weeks of gestation and lasted until 25 weeks of gestation. In the inferior colliculi, CD15 was poorly expressed in the central nucleus from 13 to 23 weeks of gestation and later with moderate levels until birth. Within the medial geniculate nucleus, a biphasic pattern of expression was observed with peaks around 14-17 and 21-24 weeks of gestation. Heterogeneous expression in the medial geniculate nucleus, which was associated either with neurons or the neuropil, allowed distinction of subnuclei. In many of the auditory pathway structures (e.g., ventral cochlear nucleus and central nucleus of the inferior colliculus), a heterogeneous pattern of CD15 expression in the form of repeating parallel bands, possibly related to tonotopic organization, became transiently apparent around 23 weeks of gestation, whereas in the magnocellular part of the medial geniculate nucleus, a striking modular or compartmental arrangement of immunoreactive structures (which could also be associated with tonotopic organization) was also noted at about 23 weeks of gestation. We propose that the initiation of CD15 expression in each nucleus heralds the appearance of functional contacts and that high levels of neuropil labeling are related to the formation of nonstabilized synaptic contacts. Thus, transient CD15 expression in the central auditory system is possibly correlated with phases of functional plasticity in this pathway.

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Section: Comparison Between the Chronology Of Known Developmental Evementioning

confidence: 99%

Section: Phases Of Intense Neuropil Labeling and (Putative Establishmmentioning

confidence: 99%

Transient CD15 expression reflects stages of differentiation and maturation in the human subcortical central auditory pathway

1999

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“…The foetal sound environment. The first series of human intraabdominal recordings was performed using microphones covered with rubber membranes which were (i) vaginally inserted close to the uterus in either pregnant (Bench, 1968, Murooka, Koie & Suda, 1976 or non-pregnant women , Tanaka & Arayama 1969, Busnel, 1979, or (ii) inside the amniotic cavity after rupture of the membranes during or after delivery , Murooka, Koie & Suda, 1976, Johansson, Wedenberg & Westin, 1964, Henshall, 1972. Except for the acoustic band analysis of Murooka et al (1967) and Busnel (1979), only global measures were performed in these studies.…”

Section: Potential Sources Of Stimulationmentioning

confidence: 99%

Sensory performances in the human foetus : a brief summary of research

Lecanuet¹,

Schaal²

2002

intel

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A growing body of evidence is available about the functioning of foetal sensory systems during gestation. This article aims at reviewing data concerning (i) the accession of sensory stimulation to the foetal sensory receptors, (ii) the sequence of functional development of the major sensory systems (iii) the physiological and behavioural responses of foetuses to various types of stimulation. Human data are confronted to data collected in other mammalian species. Most studies have investigated auditory and chemosensory (olfactory and gustatory) responsiveness of the foetus in the second half of gestation. They demonstrate that (i) motor and autonomic (heart rate) responsiveness depends on gestational age and the properties of stimulations.

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“…Consistent with the hypothesis that CD15 is prominent at sites of cellular interactions, a specific interaction between dendrites and afferents in the central nucleus of the human inferior colliculus has been described at 24 weeks of gestation (Geniec and Morest, 1971). With respect to the inferior colliculus, the period of (discrete) signs of heterogeneity of CD15 expression precedes the time from which somatic and visceral responses have been provoked by auditory stimulation of human fetuses (Fleischer, 1955;Tanaka and Arayama, 1969;Grimwalde et al, 1971;Goodlin and Schmidt, 1972;Berkson et al, 1974;Birnholtz, 1983). It remains to be determined whether the heterogeneous CD15 ϩ bands with a similar arrangement correspond to segregated laminae with functional tonotopic organization.…”

Section: Comparison Between the Chronology Of Known Developmental Evementioning

confidence: 99%

Transient CD15 expression reflects stages of differentiation and maturation in the human subcortical central auditory pathway

1999

View full text Add to dashboard Cite

The expression of the terminal saccharide determinant CD15 (3[a1–3]‐fucosyl‐N‐acetyl‐lactosamine) was evaluated in the central auditory system of the human developing brain by using monoclonal antibodies against this epitope. CD15 immunoreactivity was first observed in the ventral cochlear nucleus at 10 weeks of gestation, whereas the dorsal cochlear nucleus became positive from 13 weeks of gestation. In both nuclei, the intensity of immunoreactivity increased until 16 weeks of gestation and lasted until 25 weeks of gestation. In the inferior colliculi, CD15 was poorly expressed in the central nucleus from 13 to 23 weeks of gestation and later with moderate levels until birth. Within the medial geniculate nucleus, a biphasic pattern of expression was observed with peaks around 14–17 and 21–24 weeks of gestation. Heterogeneous expression in the medial geniculate nucleus, which was associated either with neurons or the neuropil, allowed distinction of subnuclei. In many of the auditory pathway structures (e.g., ventral cochlear nucleus and central nucleus of the inferior colliculus), a heterogeneous pattern of CD15 expression in the form of repeating parallel bands, possibly related to tonotopic organization, became transiently apparent around 23 weeks of gestation, whereas in the magnocellular part of the medial geniculate nucleus, a striking modular or compartmental arrangement of immunoreactive structures (which could also be associated with tonotopic organization) was also noted at about 23 weeks of gestation. We propose that the initiation of CD15 expression in each nucleus heralds the appearance of functional contacts and that high levels of neuropil labeling are related to the formation of nonstabilized synaptic contacts. Thus, transient CD15 expression in the central auditory system is possibly correlated with phases of functional plasticity in this pathway. J. Comp. Neurol. 404:197–211, 1999. © 1999 Wiley‐Liss, Inc.

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Fetal Responses to Acoustic Stimuli

Cited by 8 publications

References 3 publications

Transient CD15 expression reflects stages of differentiation and maturation in the human subcortical central auditory pathway

Transient CD15 expression reflects stages of differentiation and maturation in the human subcortical central auditory pathway

Sensory performances in the human foetus : a brief summary of research

Transient CD15 expression reflects stages of differentiation and maturation in the human subcortical central auditory pathway

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