Fetal responses to acoustic stimulation depend on heart rate variability pattern, stimulus intensity and repetition

Lecanuet, Jean-Pierre; Granier-Deferre, Carolyn; Cohen, Helen; Houezec, R. Le; Busnel, Marie‐Claire

doi:10.1016/0378-3782(86)90061-7

Cited by 75 publications

(37 citation statements)

References 47 publications

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“…Third, beginning with the first presentation of a VAS, the maximum FHR for each experimental trial was compared with the standard deviation during the control period. The first post-stimulation trial in which maximum FHR acceleration exceeded the control standard deviation was defined as the first response [Lecanuet et al, 1986[Lecanuet et al, , 1988. Fourth, after the first response had been detected, the number of consecutive responses was determined in which the post-stimulation FHR met the response criterion.…”

Section: Methods Of Determining Fhr Responsementioning

confidence: 99%

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Sandman¹,

Glynn²,

Wadhwa

et al. 2003

Dev Neurosci

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Maternal peptides from the hypothalamic-pituitary-adrenal (HPA) axis rise during human pregnancy. The effects of circulating maternal adrenocorticotropin (ACTH) and β-endorphin (BE) on human fetal behavior was determined in 135 women during their 32nd week of gestation. Fetal behavior was measured by assessing heart rate habituation to a series of repeated vibroacoustic stimuli. Individual differences in habituation were determined by computing the number of consecutive responses above the standard deviation during a control period. There was no significant relation between levels of ACTH, BE and the rate of fetal heart rate habituation. However, an index of HPA disregulation (uncoupling of ACTH and BE) was related significantly to fetal behavior. Fetal exposure to high levels of maternal BE relative to ACTH was associated with significantly lower rates of habituation. Results indicate that maternal stress and stress-related peptides influence fetal response patterns. It is possible that this influence persists over the life span.

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Section: Methods Of Determining Fhr Responsementioning

confidence: 99%

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Sandman¹,

Glynn²,

Wadhwa

et al. 2003

Dev Neurosci

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“…It had previously been suggested that hu man fetal responsiveness and habituation to varying stimuli is dependent on the fetal behavioral state [Hutt et al, 1968;Prechtl, 1985;Schmidt et al, 1985], Until recent studies [Granier-Deferre et al, 1985;Lecanuet et al, 1986;Gagnon et al, 1987], little attention was paid to the type and intensity of the stimulus, how it was delivered or the experimental design. These studies have shown quite clearly that fetal responses are increased by more intense stimulation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hypoxia and Catecholamines on the Habituation Rates of Chronically Catheterized Ovine Fetuses

Leader

Smith²,

Lumbers³

et al. 1989

Neonatology

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Integrated electromyographic, electrocortical (ECoG) and electro-ocular activity were recorded in 13 chronically prepared fetal sheep (130–145 days). Fetal movements and the rate of habituation to repeated suffusions of cold saline against the fetal skin were recorded. Experiments were repeated during an intravenous infusion of noradrenaline to the fetus (0.4 μg/kg estimated fetal weight/min) and during hypoxia induced by altering the oxygen content of the inspired air to the ewe to 9%. Repeated stimulation with cold saline resulted in an increase in fetal movements (p = 0.009). The number of stimuli for habituation was similar in high-voltage and in low-voltage ECoG activity. The rate of fetal habituation was significantly faster during the infusion of noradrenaline compared with control measurements (p = 0.009). During hypoxia, the number of spontaneous fetal movements prior to stimulation decreased (p = 0.002). Habituation rates were also faster during hypoxemia compared with control measurements (p = 0.003). These findings may help to explain the rapid habituation rates seen in some human fetuses in at ‘at risk’ Pregnancies.

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“…Until recent studies [Granier-Deferre et al, 1985;Lecanuet et al. 1986;Gagnon et al, 1986], little attention has been paid to the type and intensity of the stimulus, how it is delivered, or the experimental design.…”

Section: Discussionmentioning

confidence: 99%

“…Others [Granier-Deferre et al, 1985;Lecanuet et al, 1986], using an in tense broad spectrum sound stimulation, also showed consistent heart rate and fetal movement responses to stimulation. Those studies assessed the variability of the fetal heart rate at the time of stimulation and suggested that periods of low variability correspond to state IF (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…This is widely re garded as a form of learning [Buckwald and Humphrey, 1973;Kandel, 1979] and there is good evidence that a normal habituation pattern reflects an intact central nervous sys tem [Jeffrey and Cohen, 1971;Wyers et al, 1973], Human fetal movements can be easily monitored by real-time ultrasound and habi tuation of the movement response to re peated vibroacoustic stimuli has been dem onstrated using real time ultrasound [Leader et al, 1982a;Birnholz and Benacerraf, 1983;Bennett, 1984;Madison et al, 1986a] while others [Granicr-Deferre et al, 1985;Lecanuet et al, 1986] have demonstrated a decre ment in both the heart rate and fetal move ment response to broad spectrum sound stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Fetal Responses to Vibroacoustic Stimuli

Leader

Stevens²,

Lumbers³

1988

Neonatology

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Electrocortical (ECoG) and integrated electromyographic (EMG) activity was recorded in 6 chronically prepared fetal sheep (132–145 days). Recordings were made in fetuses prior to and during repeated vibroacoustic stimulation. In the undisturbed fetus, two patterns of ECoG activity were apparent; high (HV) and low voltage (LV). The fetus responded to this broad spectrum stimulus during both LV and HV ECoG activity. In 18 of the 20 experiments, repeated stimulation was not associated with a change in the background ECoG activity. All fetuses responded at least once to the stimulus. Habituation of the EMG response was observed during both HV and LV ECoG activity. The rate of habituation was independent of the background ECoG activity and was unchanged when experiments were repeated at intervals of more than 3 days. These results show that fetal sheep also respond to vibroacoustic stimulation and with repetition habituation occurs.

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Fetal responses to acoustic stimulation depend on heart rate variability pattern, stimulus intensity and repetition

Cited by 75 publications

References 47 publications

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Effect of Hypoxia and Catecholamines on the Habituation Rates of Chronically Catheterized Ovine Fetuses

Measurement of Fetal Responses to Vibroacoustic Stimuli

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