Fetal reduction for hyperreactio luteinalis

A case of recurrent hyperreactio luteinalis in three spontaneous pregnancies

“…Unlike OHSS, which is thought to be due to a defect of the follicle‐stimulating hormone or luteinizing hormone receptors or an abnormal sensitivity to VEGF, no gene variations have been reported for hyperreactio luteinalis . It has been postulated that chronically elevated hCG levels as opposed to a high hCG peak may be responsible for the development of hyperreactio luteinalis . In a normal pregnancy, hCG will rise from the time of implantation to its peak at 9 weeks' gestation (100,000–120,000 mIU/ml), then declines, and plateaus at 20–22 weeks .…”

“…6,7 It has been postulated that chronically elevated hCG levels as opposed to a high hCG peak may be responsible for the development of hyperreactio luteinalis. 8 In a normal pregnancy, hCG will rise from the time of implantation to its peak at 9 weeks' gestation (100,000-120,000 mIU/ml), then declines, and plateaus at 20-22 weeks. 9 This level has been reported as high as 2.1 3 10 6 mIU/ml in the first trimester in patients with hyperreactio luteinalis.…”