Fetal plasma cortisol and dehydroepiandrosterone sulfate concentrations in pregnancy and term parturition

Oh, Soo‐Young; Romero, Roberto; Shim, Soon Sup; Park, Joong Shin; Jun, Jong Kwan; Yoon, Bo Hyun

doi:10.1080/14767050600853179

Cited by 26 publications

(27 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fetal levels of endogenous cortisol are lower after elective CS [23,24,25,26]. Even at term, antenatal maternal treatment with betamethasone decreases the incidence of respiratory distress in infants delivered by elective CS [27].…”

Section: Discussionmentioning

confidence: 99%

Delayed Lung Liquid Absorption after Cesarean Section at Term

Martelius¹,

Janér

Süvari

et al. 2013

Neonatology

View full text Add to dashboard Cite

Background: Delayed postnatal removal of lung liquid may result in respiratory distress, which is more common in infants born by cesarean section. Vertical artefacts (B-lines) arising from the lung surface in lung ultrasound have been shown to correlate with the liquid content of the lungs. Objectives: We studied whether lung ultrasound could be used for the assessment of postnatal lung liquid in healthy term infants born vaginally and by cesarean section. Methods: Lung ultrasound was performed 1, 3 and 24 h after birth to 22 vaginally born infants and 20 infants born by elective cesarean section. The abundance of B-lines was scored for each infant and time point by two independent observers blinded to the mode of delivery and time point on the examination on a five-step scale. Results: In both groups, a significant decrease in abundance of B-lines, indicative of lung liquid absorption, was observed during the first 24 h. 3 h after birth cesarean section was associated with significantly higher lung liquid content than vaginal delivery. Conclusion: The noninvasive bedside ultrasound method for estimation of lung liquid is a promising tool for the early identification of infants at risk for pulmonary maladaptation.

show abstract

Section: Discussionmentioning

confidence: 99%

Delayed Lung Liquid Absorption after Cesarean Section at Term

Martelius¹,

Janér

Süvari

et al. 2013

Neonatology

View full text Add to dashboard Cite

show abstract

“…Symptoms may manifest as nightmares, physical complaints and difficulties in concentrating on work or on family activities [4,6]. A possible explanation for these observations can lie in increased plasma concentrations of catecholamines often seen in states of anxiety and fear [3,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The effect of attending a prenatal childbirth preparedness course on labor duration and outcomes

Yohai

Alharar

Cohen

et al. 2017

Journal of Perinatal Medicine

View full text Add to dashboard Cite

Objective: To evaluate the effect of attending a prenatal childbirth preparation course (CPC) on labor duration and outcomes. Methods: A cross sectional study of 53 primiparous women who attended and 54 women who did not attend a CPC was conducted. The state-trait anxiety inventory (STAI) score was used to diagnose anxiety. Clinical and obstetrical data were collected from the perinatal database of our center. Through post-partum interviews, coping strategies were assessed, patients graded their childbirth experience and breastfeeding was evaluated. Data were analyzed using description analyses and a P-value < 0.05 was considered statistically significant. Results: The STAI score was significantly lower in the study group compared with controls (P = 0.025). The first stage and the entire duration of labor were significantly shorter (P = 0.036 and P = 0.026, respectively) in women who attended the CPC. No significant differences were found with regard to the mode of delivery, rate of episiotomy, use of analgesics and neonatal outcomes between the groups. Women in the study group rated their labor experience significantly higher (P = 0.016) and exhibited significantly higher rates of breastfeeding (P < 0.001) than controls. Conclusions:The knowledge acquired in the CPC has positive effects on the course of labor and delivery outcomes as well as higher rates of breastfeeding.

show abstract

“…The endogenous cortisol concentrations are lower before than after 40 gestational weeks and in CD compared with VD [13,14]. In infants delivered late preterm, early term or by CD, inadequate absorption of lung liquid may contribute to a higher incidence of respiratory morbidity compared with term and VD infants [7,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Since αENaC is essential for perinatal lung liquid clearance and βENaC contributes to full activity of ENaC [4,6], lower expression of α- and βENaC could imply that late preterm and early term infants are constitutionally deficient in lung liquid clearance and therefore prone to respiratory distress. Considering the association of βENaC with cord cortisol, the steep rise in cortisol during the last weeks of pregnancy [13,14] and during labor [13,20] could induce βENaC expression. This association of βENaC expression with cortisol concentrations suggests a role for βENaC in lung liquid clearance during pulmonary adaptation and may offer support to preventive strategies for respiratory distress especially in late preterm and early term infants.…”

Section: Discussionmentioning

confidence: 99%

“…Endogenous GC levels are lower at earlier gestational age (GA) and in infants born by elective cesarean delivery (CD) compared with vaginal delivery (VD) [13,14]. In parallel, the risk for respiratory morbidity is higher in infants delivered late preterm (GA 34 0/7 -36 6/7 weeks) or even early term (GA 37 0/7 -38 6/7 weeks), especially by CD [15,16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Duration of Gestation and Mode of Delivery Affect the Genes of Transepithelial Sodium Transport in Pulmonary Adaptation

et al. 2014

View full text Add to dashboard Cite

Background: Respiratory distress due to inadequate lung liquid clearance is a significant problem in infants delivered late preterm or early term, especially by elective cesarean delivery (CD). Lung liquid clearance depends on epithelial ion transport and in animals is induced by glucocorticoids. Objectives: In newborn late preterm and term infants to study airway epithelial gene expressions of epithelial sodium channel (ENaC), and the serum and glucocorticoid-inducible kinase 1 (SGK1), and their association with cortisol, mode of delivery, and gestational age (GA). Methods: Infants were delivered at 35^0/7-41^6/7 weeks. Cortisol in umbilical cord plasma was analyzed with liquid chromatography-tandem mass spectrometry. ENaC and SGK1 mRNAs in airway epithelial cells obtained within 3 h and at 1 day postnatally were quantified with real-time PCR. Results: ENaC and SGK1 mRNAs were significantly lower in late preterm and early term infants than in those ≥39^0/7 weeks. Significant correlations existed between both ENaC and SGK1 and cord cortisol and GA. In term infants, SGK1 mRNA at 1.5 h was higher after vaginal delivery than elective CD. Conclusions: In late preterm and early term infants, low expression of ENaC and SGK1 may parallel insufficient lung liquid clearance predisposing to respiratory distress. Lower SGK1 expression after term CD could translate into insufficient sodium and lung liquid absorption. The findings demonstrate a central role for cortisol in regulation of ENaC and potentially perinatal sodium and lung liquid clearance.

show abstract

Fetal plasma cortisol and dehydroepiandrosterone sulfate concentrations in pregnancy and term parturition

Cited by 26 publications

References 36 publications

Delayed Lung Liquid Absorption after Cesarean Section at Term

Delayed Lung Liquid Absorption after Cesarean Section at Term

The effect of attending a prenatal childbirth preparedness course on labor duration and outcomes

Duration of Gestation and Mode of Delivery Affect the Genes of Transepithelial Sodium Transport in Pulmonary Adaptation

Contact Info

Product

Resources

About