Fetal pituitary transplants into the hypothalamic area of hypophysectomized rats

Akalan, Nejat; Pamir, M. Necmettin; Benlı, Kemal; Erbengi, Aykut; Erbengi, T.

doi:10.1016/0090-3019(88)90196-6

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Perspectives and Challenges On The Road To Translation1

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2016

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“…Experimental evidence of hypothalamic control upon grafting of pituitary cells requires complex assays and readouts, including stimulation tests [e.g., response to thyrotropin releasing hormone (TSH) or to growth hormone-releasing hormone (GHRH) etc. ], physiological stress tests [e.g., exposure to cold, arginine testing followed by evaluation of variations in pituitary hormone levels (Akalan et al 1988;Fisker et al 1999;Guillemin 2005)]. Behavioral testing can also contribute to the evaluation of the integrity of the hypothalamic-pituitary-target organ axis and its feedback loops.…”

Section: Perspectives and Challenges On The Road To Translationmentioning

confidence: 99%