Fetal Periventricular Hemorrhage in von Willebrand's Disease: Short Review and First Case Presentation

Mullaart, R.A.; Dongen, Pieter van; Gabreëls, F.J.M.; Oostrom, C. Von

doi:10.1055/s-2007-999374

Cited by 21 publications

(8 citation statements)

References 7 publications

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“…16 Intracranial hemorrhage is a rare event, not related to mode of delivery; cesarean delivery therefore should be reserved for obsterical indications only. 16 Von Willebrand's Disease Mullaart et al 17 noted reported increased echogenicity of the right choroid plexus and periventricular region with bilateral ventriculomegaly and a "wandering" falx cerebri at 32 weeks'gestation in a patient with Von Willebrand's disease. Interestingly, at prenatal ultrasonographic follow-up, the hemorrhage and ventriculomegaly were thought to have resolved.…”

Section: Idiopathic Thrombocytopenia Purpuramentioning

confidence: 99%

Antepartum Fetal Intracranial Hemorrhage, Predisposing Factors and Prenatal Sonography: A Review

Sherer¹,

Anyaegbunam²,

Onyeije³

1998

Amer J Perinatol

101

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Our objective was to review current literature pertaining to antepartum fetal intracranial hemorrhage. To this goal we selected all manuscripts published in the English language regarding this topic obtained from a MEDLINE search for 1966 through January 1998. Additional sources were identified through cross-referencing. Antenatal fetal intracranial hemorrhage may occur spontaneously, or occur in association with various maternal or fetal conditions. Predisposing maternal conditions at risk for this occurrence include alloimmune and idiopathic thrombocytopenia, von Willebrand's disease, specific medications (warfarin) or illicit drug (cocaine) abuse, seizures, severe abdominal trauma inflicting subsequent fetal injury, amniocentesis, cholestasis of pregnancy and febrile disease. Predisposing fetal conditions include congenital factor-X and factor-V deficiencies, hemorrhage into various congenital tumors, twin-twin transfusion, demise of a co-twin, or fetomaternal hemorrhage. Currently, antepartum fetal intracranial hemorrhage may be diagnosed by imaging techniques including ultrasonography and less frequently, magnetic resonance imaging. Early real-time sonographic signs of intracranial hemorrhage consist of irregular echogenic patterns representing the associated hematoma that may clearly distort normal intracranial structures. Recent reports have suggested Doppler flow velocimetry and color Doppler imaging as additional tools in detecting fetal intracranial hemorrhage. Various types of antenatal fetal intracranial hemorrhages that have been visualized sonographically include intraventricular, periventricular, subependymal, parenchymal, subdural, and intracerebellar events. Active hemorrhages may be associated with fetal distress manifested by fetal heart rate changes. Infrequently, antenatal ultrasonographic depiction of intracranial hemorrhage may precede devastating sequelae such as hydrocephalus, hydranencephaly, porencephaly, or microcephaly. Due to the significant associated neonatal neurological impairment and potential medicolegal implications of antepartum fetal intracranial hemorrhage, it follows that obstetricians and sonographers should be familiar with predisposing factors and typical diagnostic imaging findings of these events.

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Section: Idiopathic Thrombocytopenia Purpuramentioning

confidence: 99%

Antepartum Fetal Intracranial Hemorrhage, Predisposing Factors and Prenatal Sonography: A Review

Sherer¹,

Anyaegbunam²,

Onyeije³

1998

Amer J Perinatol

101

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“…Intracranial hemorrhage (ICH) is a common event in premature infants1, 2. It may occur in utero also, and prenatal diagnosis by either sonography or magnetic resonance imaging (MRI) has been reported3–64. Factors predisposing to in utero ICH include a variety of conditions, mostly maternal trauma and fetal coagulation disorders55.…”

Section: Introductionmentioning

confidence: 99%

Outcome of antenatally diagnosed intracranial hemorrhage: case series and review of the literature

Ghi

Simonazzi

Perolo

et al. 2003

Ultrasound in Obstet & Gyne

170

206

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“…2,8,9,11) Six of the eight patients suffered hemorrhage at ages less than 30 years. The bleeding site was intracerebral or intraventricular, and one case was secondary to ruptured arteriovenous malformation.…”

Section: Discussionmentioning

confidence: 99%

Subarachnoid Hemorrhage Associated With von Willebrand's Disease-Case Report-

Nakau

Nomura

Kida

et al. 2005

Neurol. Med. Chir.(Tokyo)

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A 59-year-old woman with type IIA von Willebrand's disease (VWD) presented with subarachnoid hemorrhage (SAH). Computed tomography showed SAH in the right sylvian fissure and intracranial hemorrhage in the right temporal lobe. Angiography demonstrated an aneurysm at the bifurcation of the right middle cerebral artery. Neck clipping was performed on the 3rd day after the onset with intraand postoperative administration of factor VIII/von Willebrand factor concentrate. No excessive bleeding occurred. Patients with prolonged bleeding time should be screened for VWD before surgery. This is a rare case of VWD presenting with SAH secondary to ruptured intracranial aneurysm. The clinical characteristics and the management of SAH in a patient with VWD are discussed.

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Fetal Periventricular Hemorrhage in von Willebrand's Disease: Short Review and First Case Presentation

Cited by 21 publications

References 7 publications

Antepartum Fetal Intracranial Hemorrhage, Predisposing Factors and Prenatal Sonography: A Review

Antepartum Fetal Intracranial Hemorrhage, Predisposing Factors and Prenatal Sonography: A Review

Outcome of antenatally diagnosed intracranial hemorrhage: case series and review of the literature

Subarachnoid Hemorrhage Associated With von Willebrand's Disease-Case Report-

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