Fetal nuchal translucency: is there an association with birthweight and neonatal wellbeing?

Kalem, Ziya; A, Ellibeş Kaya; Bakırarar, Batuhan; M, Namlı Kalem

doi:10.4274/tjod.galenos.2019.21384

Cited by 2 publications

(3 citation statements)

References 34 publications

(38 reference statements)

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“…Hackmon et al's study in 2017 showed a correlation between birth weight and early fetal measurements such as biparietal diameter (BPD) and crown-rump length (CRL), NT measurements, and NT percentiles (11). There is a predominant opinion in the literature that a correlation exists between LGA and NT measurements (2,10,13,27,30,31), but our study revealed no correlation between NT measurements and non-LGA AGA and SGA groups. Therefore, our data show that NT measurements within normal limits can be useful parameters for detecting future macrosomic or LGA fetuses.…”

Section: Discussioncontrasting

confidence: 66%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

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OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

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Section: Discussioncontrasting

confidence: 66%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

View full text Add to dashboard Cite

show abstract

“…[3] Fetuses with increased NT are at high risk for chromosomal, structural, and genetic anomalies, and generally, it is accepted as a non-specific sign of fetal abnormality. [6,7] For this reason, abnormal results detected in NT values may affect the weight of the fetus or may help us to predict other adverse outcomes. Therefore, according to the literature, ultrasound markers and biochemical markers used in the first-trimester screening test are not only used in aneuploidy risk calculation but have also been shown to predict adverse pregnancy outcomes since the first trimester of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, according to the literature, ultrasound markers and biochemical markers used in the first-trimester screening test are not only used in aneuploidy risk calculation but have also been shown to predict adverse pregnancy outcomes since the first trimester of pregnancy. [6] The aim of this study was to investigate the relationship between NT values measured in the first trimester and maternal serum free β-hCG and PAPP-A levels with term birth weight and well-being of the newborn.…”

Section: Introductionmentioning

confidence: 99%

Role of first trimester screening test in predicting the perinatal outcomes in low risk term pregnancies

Turan¹,

Turgut²,

Özdemir³

et al. 2022

Perinat J

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Objective: This study aims to investigate the relationship between the nuchal translucency (NT) values measured in the first trimester and the well-being of the newborn. Methods: The study was planned as a retrospective cross-sectional study and was conducted between January 2018 and January 2020. A total of 2394 patients who had a combined test and delivered at our university hospital were included in the study. The demographic data of the pregnant women were recorded. NT MoM values, PAPP-A and β-hCG MoM values, birth weight, gender, need for neonatal intensive care (NICU), and Apgar scores were evaluated. Results: It was found that NT (MoM) values were similar among the SGA, AGA, and LGA groups (p=0.159). PAPP-A (MoM) values were similar in the SGA group compared to AGA and LGA infant groups (p=0.947). It was also found that β-hCG (MoM) values were similar in the AGA group compared to SGA and the LGA infant groups (p=0.694). When compared with those with NICU and non-NICU, the NT, PAPP-A, β-hCG, and birth weight values were again not found to be statistically significant (p>0.05). The NT, PAPP-A, β-hCG, and male gender factors were evaluated in the Binary Logistic Regression Analysis, in which being an SGA baby was considered as a risk. It was found that a 1 mm increase in NT values increased the risk of having an SGA baby 2.63 times at a statistically significant level (OR=2.636, p=0.009, 95% CI: 1.277–5.440). PAPP-A, β-hCG levels, and having a male gender were not related to the risk of having an SGA baby. Furthermore, NT, PAPP-A, β-hCG levels, and having a male gender were not associated with the risk of NICU hospitalization. Conclusion: In conclusion, we could not predict the birth weight with increased NT MoM values that were detected in the first trimester combined test in this study; however, we found that the risk of having an SGA fetus increases with a weak rise in NT value.

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Fetal nuchal translucency: is there an association with birthweight and neonatal wellbeing?

Cited by 2 publications

References 34 publications

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Role of first trimester screening test in predicting the perinatal outcomes in low risk term pregnancies

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