Fetal nasal bone hypoplasia in the second trimester and risk of abnormal karyotype in a population of Chinese pregnant women

Du, Yan; Ren, Yunyun; Yan, Yongkun; Fu, Zhongxing; Zhu, C F; Cao, Li

doi:10.15761/tim.1000119

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“…So, the use of nasal bone length percentiles in screening may be impractical for different ethnic groups. Yan Du et al reported the hypoplastic nasal bone rate as 1.15% in the Chinese population by using 2.5% rates described in other studies [ 12 ]. As the evaluation of the fetal face may be difficult in the late second and third trimester, due to the position of the fetus, ultrasound assessment of nasal bone is more favorable in the early second trimester [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nasal bone to nasal tip length ratio for describing nasal bone hypoplasia and predicting trisomy 21

2019

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Introduction: Fetal nasal bone hypoplasia has been proven to be a strong marker for trisomy 21 during second trimester ultrasonography. Rather than evaluating the nasal bone hypoplasia according to the nomograms, it may be possible to evaluate it with a more practical and specific method. Material and methods: Retrospectively collected data were provided from the saved and stored patient data between 2012 and 2017. Nasal bone length and nasal tip length were measured and the ratio was calculated. The ratio ≤ 1/3 was defined as the threshold ratio for the definition of the marker. Nasal bone nasal tip length (NB/NL) ratio values were compared among groups with trisomy 21 and euploid fetuses. Results: A total of 59 fetuses had trisomy 21 and 2304 euploid fetuses were included in the study. The ratio of nasal bone to nasal tip length was 1/3 and below in 21/59 (35.5%) of fetuses with trisomy 21 whereas this ratio was 31/2304 (1.3%) in euploid fetuses. The difference was statistically significant (p < 0.001). Sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of nasal bone/nasal tip ratio ≤ 1/3 were 35.5%, 98.6%, 26.4 and 0.6 for Down syndrome, respectively. Conclusions: This study suggested that the nasal bone to nasal tip length ratio may be a new promising and practical sonographic marker in the second trimester genetic sonography. Although its sensitivity is not high, it seems to be more practical and specific than the evaluation of fetal nasal bone length.

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Section: Introductionmentioning

confidence: 99%

Nasal bone to nasal tip length ratio for describing nasal bone hypoplasia and predicting trisomy 21

2019

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Fetal nasal bone hypoplasia in the second trimester and risk of abnormal karyotype in a population of Chinese pregnant women

Abstract: Introduction: To evaluate the association of hypoplastic nasal bone and fetal chromosomal abnormalities in a prescreened sample of Chinese pregnant women.

Cited by 1 publication

References 16 publications

Nasal bone to nasal tip length ratio for describing nasal bone hypoplasia and predicting trisomy 21

Nasal bone to nasal tip length ratio for describing nasal bone hypoplasia and predicting trisomy 21

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