Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: prospective evaluation of 1018 cases

Enders, Martin; Weidner, Andrea; Zoellner, Iris; Searle, Karen; Enders, Gisela

doi:10.1002/pd.940

Cited by 289 publications

(186 citation statements)

References 29 publications

(31 reference statements)

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“…This rate of adverse fetal outcome is similar to rates of 5 to 10%, previously reported from other countries (Miller et al 1998;Searle et al 1998;Enders et al 2004). This study also indicates that the week of gestation, when the patient was infected, is an important determinant of adverse fetal outcome.…”

Section: Discussionsupporting

confidence: 73%

“…It is possible that there are both qualitative and quantitative differences in the immune response of asymptomatic women because the rash and arthralgia in B19 infection are immune mediated. On the other hand, Enders et al (2004) have reported that there was no association between the presence of maternal symptoms and the incidence of non-hydropic fetal death or hydrops fetalis, although the presence of rash and/or arthropathy between 9 and 16 weeks of gestation was associated with an increased risk of non-hydropic fetal death. In this study, patients with adverse fetal effects tended to be symptomatic including rash and fever, which is consistent with the data of Enders et al (2004).…”

Section: Discussionmentioning

confidence: 96%

“…On the other hand, Enders et al (2004) have reported that there was no association between the presence of maternal symptoms and the incidence of non-hydropic fetal death or hydrops fetalis, although the presence of rash and/or arthropathy between 9 and 16 weeks of gestation was associated with an increased risk of non-hydropic fetal death. In this study, patients with adverse fetal effects tended to be symptomatic including rash and fever, which is consistent with the data of Enders et al (2004). However, larger studies are needed to better outline the prevalence of infection and to clarify the role of the maternal immune response in the pathogenesis of B19 infection.…”

Section: Discussionmentioning

confidence: 96%

“…Prospective studies have estimated the incidence of hydrops fetalis or fetal death secondary to B19 infection to be 2-24% (Yaegashi et al 1999b), with the highest rate of fetal complications seen if infection occurs in the first 20 weeks of gestation (Miller et al 1998;Enders et al 2004). Retrospective studies have shown B19 infection to be responsible for 10-50% of cases of hydrops fetalis, in which the etiology was unknown .…”

confidence: 99%

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Clinical Manifestations and Outcomes of Parvovirus B19 Infection during Pregnancy in Japan

Chisaka

Itō

Niikura

et al. 2006

Tohoku J. Exp. Med.

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Parvovirus B19 is a small DNA virus. Infection with parvovirus B19 during pregnancy may cause serious complications in the fetus, including hydrops fetalis and fetal death. The purpose of the present study is to clarify the clinical manifestations and outcomes of parvovirus B19 infection during pregnancy. This prospective study enrolled 478 women with suspected B19 infections during pregnancy between 1999 and 2004. One hundred cases (21%) of B19 infection were detected in 478 pregnant women who had been exposed to B19. Serological infection was confirmed by measurement of B19-specific IgM and IgG in sera. Forty-nine cases reported maternal clinical symptoms and 51 cases were asymptomatic. Facial rash was the most common symptom, with 51% (25/49) of the symptomatic patients complaining of either a facial, body or limb rash. The most common infectious source was children living in the home. Overall, the incidence of adverse fetal effects (including hydrops fetalis and fetal death) related to intrauterine B19 infection was 7% (7/100), and all seven cases were exposed to B19 infection before 20 weeks of gestation. Although half of the cases with parvovirus B19 infections during pregnancy were asymptomatic, patients with adverse fetal effects tended to be symptomatic including rash and fever. These clinical data may supply useful information to produce clinical guidelines for managing B19 infection during pregnancy. parvovirus B19; pregnancy; clinical manifestation; hydrops fetalis; fetal outcome

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

confidence: 99%

See 2 more Smart Citations

Clinical Manifestations and Outcomes of Parvovirus B19 Infection during Pregnancy in Japan

Chisaka

Itō

Niikura

et al. 2006

Tohoku J. Exp. Med.

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“…Currently, there are three B19V genotypes with associated subtypes, genotype 1a, 1b, 2, 3a, and 3b. 16 The genotypes show ∼10% nucleotide divergence on the whole genome. 5 The most prevalent B19V genotype in Northern Europe is genotype 1a.…”

Section: Discussionmentioning

confidence: 99%

Genotype 1 of human parvovirus B19 in clinical cases

Oliveira

Afonso

Curti

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction: Virus surveillance strategies and genetic characterization of human parvovirus B19 (B19V) are important tools for regional and global control of viral outbreak. In São Paulo, Brazil, we performed a study of B19V by monitoring the spread of this virus, which is an infectious agent and could be mistakenly reported as a rash and other types of infection. Method: Serum samples were subjected to enzyme immunoassay, real time polymerase chain reaction, and sequencing. Results: From the 462 patients with suspected cases of exanthematic infections, the results of the 164 serum samples were positive for B19V immunoglobulin M. Among these cases, there were 38 patients with erythema infections and B19--associated with other infections such as encephalitis, hydrops fetalis, chronic anemia, hematological malignancies. These samples were sequenced and identified as genotype 1. Conclusion: This study showed patients with infections caused by B19V and sequencing genotype 1. Continuous monitoring is necessary to detect all known genotypes, and the emergence of new genotypes of these viruses for case management in public health control activities.

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Viral Infections of the Fetus and Neonate, other than Rubella

Enders¹

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: prospective evaluation of 1018 cases

Cited by 289 publications

References 29 publications

Clinical Manifestations and Outcomes of Parvovirus B19 Infection during Pregnancy in Japan

Clinical Manifestations and Outcomes of Parvovirus B19 Infection during Pregnancy in Japan

Genotype 1 of human parvovirus B19 in clinical cases

Viral Infections of the Fetus and Neonate, other than Rubella

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