2008
DOI: 10.1158/0008-5472.can-08-3008
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Fetal Microchimerism and Cancer

Abstract: The persistence of fetal stem cells with multilineage potential in women who have been pregnant, a phenomenon known as fetal microchimerism, is emerging as a potential contributing factor in certain diseases, including cancer. For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer. Studies of this phenomenon may provide a novel perspective on cancer in women, including in breast, ovarian, and lung cancers. [Cancer Res 2008;68(23):9567-9]

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Cited by 22 publications
(11 citation statements)
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“…For example, CD45 or cytokeratin staining could be used to help determine whether these cells are leukocytes or trophoblasts, and stem cell antibody panels could be used to determine whether they are progenitor cells that may play a role in maternal tissue repair. In addition, since fetal cells have been hypothesized to play a role in maternal tumorigenesis [21], future experiments could be designed as well to test this hypothesis with regard to lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…For example, CD45 or cytokeratin staining could be used to help determine whether these cells are leukocytes or trophoblasts, and stem cell antibody panels could be used to determine whether they are progenitor cells that may play a role in maternal tissue repair. In addition, since fetal cells have been hypothesized to play a role in maternal tumorigenesis [21], future experiments could be designed as well to test this hypothesis with regard to lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, Sawicki hypothesized that fetal cells have tumorigenic potential and can act as cancer stem cells (26). She described a case in which fetal cells constituted the majority of lung tumors in a murine model.…”
Section: Studies Of Neoplastic Tissuementioning
confidence: 99%
“…Des donné es ré centes suggè rent une association entre grossesse, microchimé risme et cancer [90,91]. La probabilité d'avoir un cancer serait moindre chez les femmes multipares avec microchimé risme que chez celles sans microchimé risme [92].…”
Section: Microchime´risme Foetal Et Cancersunclassified