“…The clinical picture in these children was confirmed as similar to that reported in Japan (8)(9)(10)(12)(13)(14). Mercury levels in maternal hair growing during pregnancy were determined and, for the first time, assessment of associations between the level and timing of exposure and the children's disabilities was possible, thus providing a dose-response relationship (15).…”
Section: Exposure Data From Poisoning In Japansupporting
confidence: 74%
“…Its toxicity has been known for centuries (4) and multiple episodes of poisoning in children by both inorganic and organic mercury have been reported (5,6). The organic forms of mercury are particularly neurotoxic (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Both prenatal and postnatal exposure to MeHg can adversely affect the central nervous system, but it appears to be most neurotoxic prenatally when the brain is developing rapidly.…”
Section: Human Effects Of Methylmercurymentioning
confidence: 99%
“…Harada (24) studied 223 schoolchildren [13][14][15][16] years of age in the Minamata area and compared them with 196 controls. He reported a significantly higher frequency of intellectual deficiency (18 vs.…”
Section: Exposure Data From Poisoning In Japanmentioning
confidence: 99%
“…More than 80 infants who were in utero during the time the MeHg-treated grain was being consumed by the mothers were examined and their prenatal exposure determined (14,15). Using the peak maternal hair mercury level during pregnancy and two end points [the child's neurological examination ( Figure 1) and the age they first walked, as reported by the mothers (Figure 2) hair mercury concentrations at or above these levels (1,28).…”
Section: Exposure Data From Poisoning In Japanmentioning
confidence: 99%
“…The effects of such differing types of exposure are unknown but may be important (29). In addition, the Iraq study had a number of limitations (14). The birth dates of the children were not precisely known.…”
Section: Exposure Data From Poisoning In Japanmentioning
“…The clinical picture in these children was confirmed as similar to that reported in Japan (8)(9)(10)(12)(13)(14). Mercury levels in maternal hair growing during pregnancy were determined and, for the first time, assessment of associations between the level and timing of exposure and the children's disabilities was possible, thus providing a dose-response relationship (15).…”
Section: Exposure Data From Poisoning In Japansupporting
confidence: 74%
“…Its toxicity has been known for centuries (4) and multiple episodes of poisoning in children by both inorganic and organic mercury have been reported (5,6). The organic forms of mercury are particularly neurotoxic (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Both prenatal and postnatal exposure to MeHg can adversely affect the central nervous system, but it appears to be most neurotoxic prenatally when the brain is developing rapidly.…”
Section: Human Effects Of Methylmercurymentioning
confidence: 99%
“…Harada (24) studied 223 schoolchildren [13][14][15][16] years of age in the Minamata area and compared them with 196 controls. He reported a significantly higher frequency of intellectual deficiency (18 vs.…”
Section: Exposure Data From Poisoning In Japanmentioning
confidence: 99%
“…More than 80 infants who were in utero during the time the MeHg-treated grain was being consumed by the mothers were examined and their prenatal exposure determined (14,15). Using the peak maternal hair mercury level during pregnancy and two end points [the child's neurological examination ( Figure 1) and the age they first walked, as reported by the mothers (Figure 2) hair mercury concentrations at or above these levels (1,28).…”
Section: Exposure Data From Poisoning In Japanmentioning
confidence: 99%
“…The effects of such differing types of exposure are unknown but may be important (29). In addition, the Iraq study had a number of limitations (14). The birth dates of the children were not precisely known.…”
Section: Exposure Data From Poisoning In Japanmentioning
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