Fetal Magnetoencephalography (fMEG)

Keune, Jana; Eswaran, Hari; Preißl, Hubert

doi:10.1007/978-3-030-00087-5_23

Cited by 4 publications

(9 citation statements)

References 36 publications

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“…In a subset of pregnant women, an additional measurement of fetal brain activity and heart rate is performed at the Tübingen site during the OGTT (ethics board number 339/2010BO1). 35–37 Measurements are conducted with the specially developed fMEG system SARA II (SQUID Array for Reproductive Assessment; VSM MedTech, Port Coquitlam, Canada). This device contains 156 integrated primary and 29 reference sensors (SQUID coils) to capture magnetic signals elicited by the fetal brain (fMEG) and heart (fMCG) and was developed to provide information on adverse in utero condition, for example, arrhythmias.…”

Section: Methodsmentioning

confidence: 99%

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The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design

et al. 2022

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IntroductionEven well-treated gestational diabetes mellitus (GDM) might still have impact on long-term health of the mother and her offspring, although this relationship has not yet been conclusively studied. Using in-depth phenotyping of the mother and her offspring, we aim to elucidate the relationship of maternal hyperglycaemia during pregnancy and adequate treatment, and its impact on the long-term health of both mother and child.MethodsThe multicentre PREG study, a prospective cohort study, is designed to metabolically and phenotypically characterise women with a 75-g five-point oral glucose tolerance test (OGTT) during, and repeatedly after pregnancy. Outcome measures are maternal glycaemia during OGTTs, birth outcome and the health and growth development of the offspring. The children of the study participants are followed up until adulthood with developmental tests and metabolic and epigenetic phenotyping in the PREG Offspring study. A total of 800 women (600 with GDM, 200 controls) will be recruited.Ethics and disseminationThe study protocol has been approved by all local ethics committees. Results will be disseminated via conference presentations and peer-reviewed publications.Trial registration numberThe PREG study and the PREG Offspring study are registered with Clinical Trials (ClinicalTrials.gov identifiers: NCT04270578, NCT04722900).

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design

et al. 2022

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Section: Fetal Magnetencephalography (Fmeg) and Magnetocardiography (Fmcg)mentioning

confidence: 99%

The German Gestational Diabetes Study (PREG): Rationale, Methodology and Design

Fritsche

Hummel

Wagner

et al. 2021

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Since the introduction of the new International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria for gestational diabetes mellitus (GDM) in 2012, diagnosis and treatment of GDM has improved. But even well-treated GDM might still have impact on long-term health of the mother and her offspring, though, this relation has not been conclusively studied yet. The multicenter PREG study is designed to metabolically and phenotypically characterize women with a 75 g five-point oral glucose tolerance test (OGTT) during and repeatedly after pregnancy. The offspring of the study participants are followed up until adulthood with developmental tests and metabolic and epigenetic phenotyping in the PREG offspring study. By in-depth phenotyping of the mother and her offspring, we aim to elucidate the relationship of maternal hyperglycemia during pregnancy and adequate treatment and its impact on the long-term health for both.

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“…Yet the unique physics of magnetic fields, which, unlike electric fields, pass nearly unimpeded through tissues as emphasized above, allows for noninvasive fetal imaging via magnetic sensors positioned around a pregnant woman's abdomen or an infant's head. As with most other MEG systems, the magnetic sensors of current fetal MEG devices are extremely sensitive superconducting quantum interference device (SQUID) coils capable of detecting biomagnetic fields on the order of femtoteslas (Keune et al, 2019). However, next-generation devices will likely use OPMs (Escalona-Vargas et al, 2020;Wakai, 2014) to record fetal MEG signals in a flexible manner, with sensor placement unconstrained by the cryogenic dewar used in SQUID-based systems (Fig.…”

Section: Introduction To Perinatal Meg and Eegmentioning

confidence: 99%

“…Of the > 100 MEG centers worldwide that are registered on Biomag Central (Biomag Central, 2017), only four are capable of detecting biomagnetic fetal signals (Fig. 2), and of these, only two are dedicated to fetal MEG (Keune et al, 2019). As mentioned above, recent advances in room-temperature OPMs which do not require a fixed-size helmet may expand the currently small number of sites with fetal MEG capabilities, as the OPM equipment does not need to be custom-built for fetal applications but can instead be adapted for new purposes (Brookes et al, 2022).…”

Section: Introduction To Perinatal Meg and Eegmentioning

confidence: 99%