Fetal Magnetic Resonance Imaging Findings in Prenatal Zika Virus Infection

Sanín-Blair, José Enrique; Gutiérrez-Márquez, C; Herrera, Diego A.; Vossough, Arastoo

doi:10.1159/000454860

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Ventriculomegaly was described in 32 studies reviewed [19,23,45,56,56,58,[63][64][65][66][67][68][69][70][71][72][73][74]76,[78][79][80][82][83][84][87][88][89][90][91][92][93][94]96,98,100], an important sign regarding the risk of developing hydrocephalus and the need for surgical intervention for ventriculoperitoneal shunt, which was also observed…”

Section: Discussionmentioning

confidence: 99%

Congenital Zika syndrome: A systematic review

et al. 2020

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Background The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. Methods and findings A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. Conclusions Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols.

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Section: Discussionmentioning

confidence: 99%

Congenital Zika syndrome: A systematic review

et al. 2020

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“…A frequent and typical finding at F-MRI is redundant scalp skin in the occipital region, which may also be seen at postnatal imaging or even during physical examination of the newborn [26]. Conversely, when compared with ultrasound, prenatal MRI is less sensitive in the detection of parenchymal calcifications [82].…”

Section: Prenatal Mr Imagingmentioning

confidence: 99%

Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities

Vhp

Aragão

Pinho

et al. 2020

Curr Neurol Neurosci Rep

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Purpose of Review In 2016, the World Health Organization declared the Zika virus (ZIKV) outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. Our aim is to review the clinical and neuroimaging findings seen in congenital Zika syndrome. Recent Findings ZIKV injures neural progenitor cells in the hippocampus, a brain region important for learning, memory, cognition, and emotion/stress response. Positron emission tomography has revealed global neuroinflammation in ZIKV infection in animal models. Summary Congenital Zika syndrome is associated with a spectrum of brain abnormalities, including microcephaly, parenchymal calcifications, malformations of cortical development and defective neuronal migration, corpus callosum abnormalities, ventriculomegaly, and brainstem and cerebellar abnormalities.

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“…61,62 Asymptomatic fetal infection is common. 63 Along with IUGR, 64 ventriculomegaly, 61,[64][65][66][67][68] severe microcephaly with diffuse cortical thinning 61,[65][66][67][68][69][70], and brain calcifications have commonly been reported. [64][65][66][67]69 Migration anomalies, 64,65,[67][68][69]71 callosal dysgenesis, 61,[65][66][67]69 cerebellopontine hypoplasia, 65,66,[68][69][70][71] occipital subependymal pseudocysts/synechiae 65,66,69 and abnormal lamination, 61,66 collapsing deformity of the skull vault, 67 and fetal akinesia sequence 68 have also been reported.…”

Section: Zika Virusmentioning

confidence: 99%

Neuroimaging of Fetal Infection

Robinson¹,

Ederies²,

Bailäo³

et al. 2017

J Pediatr Neurol

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Infection during pregnancy is common and the developing fetal brain is vulnerable to vertical transmission due to immaturity of the fetal immune system. Infection is a major cause of multiple organ abnormalities, including the neuraxis, due to the neurotropism of the infectious agents. This review sets out to give an overview of fetal infection, review the general principles of the nature and timing of the infectious insult with respect to outcomes, review the neuroimaging of infection by ultrasound and magnetic resonance imaging (MRI), and review the various pathogens involved, including the two most common, cytomegalovirus (CMV) and Toxoplasma, and also other common viral and nonviral infections.

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Fetal Magnetic Resonance Imaging Findings in Prenatal Zika Virus Infection

Cited by 7 publications

References 9 publications

Congenital Zika syndrome: A systematic review

Congenital Zika syndrome: A systematic review

Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities

Neuroimaging of Fetal Infection

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