Fetal loss and sickle cell trait: a valid association

Tita, Alan T.N.; Biggio, Joseph R.

doi:10.1016/j.ajog.2006.11.010

Cited by 2 publications

(1 citation statement)

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“…54–56 Of the pregnancy-associated complications, asymptomatic bacteriuria has shown the most consistent associations with SCT in the literature. 55,57 …”

Section: Clinical Complications In Sctmentioning

confidence: 99%

Sickle cell trait diagnosis: clinical and social implications

2015

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The sickle hemoglobin (HbS) point mutation has independently undergone evolutionary selection at least five times in the world because of its overwhelming malarial protective effects in the heterozygous state. In 1949, homozygous Hb S or sickle cell disease (SCD) became the first inherited condition identified at the molecular level; however, since then, both SCD and heterozygous Hb S, sickle cell trait (SCT), have endured a long and complicated history. Hasty adoption of early mass screening programs for SCD, recent implementation of targeted screening mandates for SCT in athletics, and concerns about stigmatization have evoked considerable controversy regarding research and policy decisions for SCT. Although SCT is a largely protective condition in the context of malaria, clinical sequelae, such as exercise-related injury, renal complications, and venous thromboembolism can occur in affected carriers. The historical background of SCD and SCT has provided lessons about how research should be conducted in the modern era to minimize stigmatization, optimize study conclusions, and inform genetic counseling and policy decisions for SCT.

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“…54–56 Of the pregnancy-associated complications, asymptomatic bacteriuria has shown the most consistent associations with SCT in the literature. 55,57 …”

Section: Clinical Complications In Sctmentioning

confidence: 99%

Sickle cell trait diagnosis: clinical and social implications

2015

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Current awareness in prenatal diagnosis

2007

Prenatal Diagnosis

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of prenatal diagnosis. Each bibliography is divided into 17 sections: 1 Reviews; 2 General Interest; 3 Normal Fetal Development; 4 Gametogenesis and Pre‐implantation Diagnosis; 5 First Trimester Diagnosis; 6 Second Trimester Diagnosis; 7 Fetal Diagnosis by Ultrasound and Other Imaging; 8 Maternal Screening; 9 Screening for Carriers of Genetic Abnormality; 10 Technological Developments; 11 Confined Placental Mosaicism and Uniparental Disomy; 12 Molecular Cytogenetics; 13 Fetal Cells in Maternal Circulation; 14 Fetal Therapy; 15 Psychosocial Aspects; 16 Epidemiology and Environmental Factors; 17 Developmental Pathology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Fetal loss and sickle cell trait: a valid association

Cited by 2 publications

References 1 publication

Sickle cell trait diagnosis: clinical and social implications

Sickle cell trait diagnosis: clinical and social implications

Current awareness in prenatal diagnosis

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