Fetal Loss Among Pregnancies Conceived through Assisted Reproductive Technology

Farr, Sherry L.; Schieve, La; Jamieson, D.J.

doi:10.1093/aje/163.suppl_11.s75-a

Cited by 16 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Use of ICSI may bypass the natural elimination process of abnormal sperm and may allow the inheritance of imprinting mutations. This may be linked to the increased frequency of miscarriage, placental dysfunction, premature labor, intrauterine growth retardation, placenta previa and maternal hypertension, and obstetric and neonatal complications associated with ART (33)(34)(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis

Satô

Hiura

Okae

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis

Satô

Hiura

Okae

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

“…The cumulative pregnancy rate observed across up to 12 insemination cycles was 74% for women younger than 31 years, decreased to 62% for women aged 31-35 years and decreased further to 54% for women older than 35 years [2]. Therefore, the pregnancy success rate of older women is significantly reduced in regard to both natural conception and assisted reproductive technology [15,16]. Several indicators can be used to assess ovarian reserve function, including FSH, inhibin B, AMH and AFC.…”

Section: Discussionmentioning

confidence: 99%

Fecundity disorders in older women: declines in follicular development and endometrial receptivity

Wang

Mao

et al. 2020

BMC Women's Health

View full text Add to dashboard Cite

Background: Little research is available on follicular development and endometrial receptivity in older women. This study aimed to assess follicular development and endometrial receptivity, and to evaluate ultrasonic parameters in predicting endometrial receptivity during the implantation window in older women. Methods: For this prospective case-control study, 224 older women and 215 young women were recruited. The follicular development and endometrial thickness were monitored by transvaginal ultrasound. During the implantation window, the pulsatility index (PI) and resistance index (RI) of the uterine arteries and subendometrial region, endometrial volume, vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were calculated between the two groups. The ultrasonic parameters were used to assess endometrial receptivity in older women. Results: The serum anti-Mullerian hormone (AMH) concentration and antral follicle count (AFC) were significantly lower in older women than in young women. The average diameter of the dominant follicle on days 14, 16, and 18 of the menstrual cycle were significantly smaller, and the subendometrial region RI on days 12, 14, 16, and 18 of the menstrual cycle were significantly higher in older women than in young women. The normal ovulation rate was significantly lower in older women than in young women. The subendometrial region RI was significantly higher, and the endometrial VI, FI, and VFI were significantly lower in older women compared with young women. The biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate of older women were significantly lower than in young women. The best ultrasonic parameter for predicting endometrial receptivity during the implantation window in older women was VI (AUC =0.889, sensitivity 92.6% and specificity 85.4%). Conclusions: Older women present decreased serum AMH concentrations and AFC, defined as indicators of ovarian reserve function. Older women are characterized by decreased follicular development and endometrial receptivity, which may lead to fecundity disorders.

show abstract

“…The cumulative pregnancy rate observed across up to 12 insemination cycles was 74% for women younger than 31 years, decreased to 62% for women aged 31-35 years and decreased further to 54% for women older than 35 years [2]. Therefore, the pregnancy success rate of older women is significantly reduced in regard to both natural conception and assisted reproductive technology [14][15]. Several indicators can be used to assess ovarian reserve function, including FSH, inhibin B, AMH and AFC.…”

Section: Discussionmentioning

confidence: 99%

Fecundity disorders in older women: declines in follicular development and endometrial receptivity

Wang

Mao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background : Little research is available on follicular development and endometrial receptivity in older women. This study aimed to assess follicular development and endometrial receptivity, and to evaluate ultrasonic parameters in predicting endometrial receptivity during the implantation window in older women.Methods: For this prospective case-control study, 224 older women and 215 young women were recruited. The follicular development and endometrial thickness were monitored by transvaginal ultrasound. During the implantation window, the pulsatility index (PI) and resistance index (RI) of the uterine arteries and subendometrial region, endometrial volume, vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were calculated between the two groups. The ultrasonic parameters were used to assess endometrial receptivity in older women.Results: The serum anti-Mullerian hormone (AMH) concentration and antral follicle count (AFC) were significantly lower in older women than in young women. The average diameter of the dominant follicle on days 14, 16, and 18 of the menstrual cycle were significantly smaller, and the subendometrial region RI on days 12, 14, 16, and 18 of the menstrual cycle were significantly higher in older women than in young women. The normal ovulation rate was significantly lower in older women than in young women. The subendometrial region RI was significantly higher, and the endometrial VI, FI, and VFI were significantly lower in older women compared with young women. The biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate of older women were

show abstract

Fetal Loss Among Pregnancies Conceived through Assisted Reproductive Technology

Cited by 16 publications

References 0 publications

Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis

Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis

Fecundity disorders in older women: declines in follicular development and endometrial receptivity

Fecundity disorders in older women: declines in follicular development and endometrial receptivity

Contact Info

Product

Resources

About