Fetal Islet Transplantation in Diabetic Mice: A Model for Human Islet Transplants

Effects of bacterial infection on insulin secretory capacity of human adult pancreatic islets

“…However, it has been shown that bacterial competition occurs in the culture whereby Enterobacter suppresses the growth of Pseudomonas and Staphylococcus; therefore, a much higher SI on day 7 in cultures contaminated with Enterobacter can be explained. 19,20 The present results are in accordance with research using a microbial biopolymer (PGB1) extracted from Enterobacter sp. and tested in db/db mice.…”

“…surfaces, and ii) elaborate proteases, exotoxins and enzymes that destroy tissue and protect bacteria from the host immune response. 19 Pseudomonas aeruginosa produces membrane vesicles (MVs) that are released into the culture medium during normal growth. Their release is increased approximately three-fold after exposure of the organism to four times the minimum inhibitory concentration (MIC) of gentamicin.…”

Phenotypic characterization of neural stem cells from human fetal spinal cord: Synergistic effect of LIF and BMP4 to generate astrocytes

“…It has also been shown that immature, but not mature, cultured astrocytes have the capacity to support in vitro neurogenesis from NSC (Song et al, 2002) as well as axon outgrowth when transplanted into the CNS (Smith et al, 1990). Moreover, due to their ability to proliferate, their intrinsic plasticity and reduced antigenicity, when compared with adult tissue, fetal cells are considered clinically important for medical transplantation (Mandel, 1992;Statter et al, 1989). Taken together, this suggests that immature human spinal cord derived GFAP 1 astrocytes can be suitable candidates for further experimental studies to determine their ability to treat acute spinal cord injury.…”