Fetal intracranial immature teratoma: presentation of a case and a systematic review of the literature

Fradejas, M Robles; García, I Gonzalo; Quispe, A C De Las Casas; García, Alonso M. Pilar; Higuera, M I García; Minguélez, M Rodriguez; Martínez-Guisasola, J

doi:10.1080/14767058.2016.1205029

Cited by 16 publications

(32 citation statements)

References 22 publications

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“…However, there have been some reports in which infants survived for a long time, such as our current case and that of Fukuoka et al [15]. Long-term survival can be attributed to complete resection, yet this has not been entirely proven [20]. The location and the size of the teratoma are considered as significant prognostic factors rather than the histological grade [2].…”

Section: Discussionmentioning

confidence: 81%

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

2019

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BackgroundCongenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis.Case presentationA newborn female, diagnosed prenatally with hydrocephalus, is presented at birth with increasing head circumference and Parinaud’s syndrome. Magnetic resonance imaging scans demonstrated a huge posterior fossa tumor with obstructive hydrocephalus. At surgery, through a suboccipital craniotomy, complete excision was achieved of a histological-proven immature teratoma. The infant received adjuvant chemotherapy for 1 year. She had normal neurological development and remained tumor-free through her 20-year follow-up.ConclusionThe authors report this rare case of congenital posterior fossa teratoma with long-term outcome, and the literature is reviewed.

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Section: Discussionmentioning

confidence: 81%

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

2019

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“…[ 21 ] The prognosis of congenital intracranial immature teratoma is usually poor because the tumor is usually large and is accompanied by extensive invasion. [ 7 – 10 , 14 ] Late recurrence is uncommon in these patients, [ 22 ] but Mano et al reported a case of intracranial immature teratoma that recurred 21 years after the surgery of the primary tumor. [ 22 ] There are few reports of tumors in adults, and the prognosis in these cases remains to be studied.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 , 4 ] Congenital tumors usually involve a relatively wide area of the brain. [ 5 , 6 ] The prognoses of primary intracranial immature teratomas in the fetus and newborn are generally poor, [ 4 , 7 – 11 ] while prognostic data in adults are currently lacking. Herein, we report a rare case of primary intracranial immature teratoma in a 27-year-old woman.…”

Section: Introductionmentioning

confidence: 99%

Intracranial immature teratoma invading the nasal cavity mimicking olfactory neuroblastoma

et al. 2018

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Rationale:Primary intracranial immature teratoma accounts for majority of congenital central nervous system germ-cell tumors, but it is extremely rare in patients older than 15 years.Patient concerns:A 27-year-old woman was referred to our hospital for headache, nasal congestion, and decreased olfactory sensation. Imaging showed a mass measuring approximately 5 cm × 4 cm in the right frontal lobe, which also filled the right nasal cavity. Histopathologically, the intracranial tumor tissues were composed of both mature tissues, including glands and squamous epithelial cells and immature neuroectodermal components. However, the tumor tissues in the nasal cavity were mainly immature neuroectodermal components that mimicked olfactory neuroblastoma. The cells stained positively for neuron-specific enolase, Alpha Thalassemia/Mental Retardation Syndrome X-Linked, and Oligodendrocyte transcription factor on immunostaining, proving a neuroectodermal differentiation.Diagnoses:According to these findings, the tumor was diagnosed as a primary intracranial immature teratoma that also involved the nasal cavity after excluding the metastatic tumors.Interventions:The patient underwent 2 surgeries. The first surgery was via the subfrontal approach, followed by a second endoscopic sinus surgery performed 22 days later.Outcomes:The patient had no recurrence within a 6-month follow-up after the last surgery.Lessons:When an intracranial immature teratoma involves the nasal cavity, the lesions in the nasal cavity may mimic other tumors including olfactory neuroblastoma. We suggest that thorough examination of tumor tissues and identification of variable components are critical for the appropriate diagnosis of intracranial immature teratoma, a rare tumor.

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“…Congenital intracranial tumours are rare. These account for < 2% of all foetal tumours [35], and teratomas forming the vast majority of all subtypes (Figs. 6 and 7).…”

Section: Systems Reviewmentioning

confidence: 99%

Perinatal post-mortem ultrasound (PMUS): radiological-pathological correlation

2019

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There has been an increasing demand and interest in post-mortem imaging techniques, either as an adjunct or replacement for the conventional invasive autopsy. Post-mortem ultrasound (PMUS) is easily accessible and more affordable than other cross-sectional imaging modalities and allows visualisation of normal anatomical structures of the brain, thorax and abdomen in perinatal cases. The lack of aeration of post-mortem foetal lungs provides a good sonographic window for assessment of the heart and normal pulmonary lobulation, in contrast to live neonates. In a previous article within this journal, we published a practical approach to conducting a comprehensive PMUS examination. This covered the basic principles behind why post-mortem imaging is performed, helpful techniques for obtaining optimal PMUS images, and the expected normal post-mortem changes seen in perinatal deaths. In this article, we build upon this by focusing on commonly encountered pathologies on PMUS and compare these to autopsy and other post-mortem imaging modalities.

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Fetal intracranial immature teratoma: presentation of a case and a systematic review of the literature

Abstract: As the incidence of intracranial immature teratomas is very low and the prognosis is poor, their prenatal diagnosis and obstetric management present a great challenge for the planning of a follow-up and treatment of the disease in accordance with the preferences of the parents.

Cited by 16 publications

References 22 publications

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

Intracranial immature teratoma invading the nasal cavity mimicking olfactory neuroblastoma

Perinatal post-mortem ultrasound (PMUS): radiological-pathological correlation

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