2016
DOI: 10.1186/s13256-016-0924-5
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Fetal hypoxia secondary to severe maternal anemia as a causative link between blueberry muffin baby and erythroblastosis: a case report

Abstract: BackgroundNeonatal blueberry muffin lesions are rare cutaneous eruptions, presenting as transient, non-blanching, red-violaceous papules, mostly localized in the trunk, head and neck, attributable to a marked dermal hematopoietic activity. Congenital infections of the TORCH complex (toxoplasmosis, other, rubella, cytomegalovirus and herpes) and hematological disorders have been classically associated with this neonatal dermatological manifestation. We report for the first time an unusual presentation of bluebe… Show more

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Cited by 5 publications
(6 citation statements)
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“…Дифференциальная диагностика кожных высыпаний у новорожденных является сложной задачей, поскольку причиной кожной сыпи у новорожденного могут быть самые разнообразные состояния, такие как врожденные инфекции, перинатальная анемия, вызванная гемолитической болезнью (несовместимость по Rh-фактору, системе ABO), наследственный сфероцитоз, фето-фетальный трансфузионный синдром, фетоплацентарная недостаточность, внутричерепное кровоизлияние, нейродегенеративные заболевания (синдром Айкарди-Гутьерес), неонатальная красная волчанка, новообразования и аутоиммунные или гематологические нарушения [8,9,14,15].…”
Section: Discussionunclassified
“…Дифференциальная диагностика кожных высыпаний у новорожденных является сложной задачей, поскольку причиной кожной сыпи у новорожденного могут быть самые разнообразные состояния, такие как врожденные инфекции, перинатальная анемия, вызванная гемолитической болезнью (несовместимость по Rh-фактору, системе ABO), наследственный сфероцитоз, фето-фетальный трансфузионный синдром, фетоплацентарная недостаточность, внутричерепное кровоизлияние, нейродегенеративные заболевания (синдром Айкарди-Гутьерес), неонатальная красная волчанка, новообразования и аутоиммунные или гематологические нарушения [8,9,14,15].…”
Section: Discussionunclassified
“…[1][2][3] Most frequent are infections of the TORCH complex (toxoplasmosis, rubeola, cytomegalovirus, herpes). 4,5 This case was unique in that the mother had a confirmed case of COVID-19 (positive PCR test) shortly before giving birth, and this was the only risk factor explaining why COVID-19 was the likely cause of extramedullary hematopoiesis.…”
Section: Case Presentationmentioning
confidence: 99%
“…[46] A recent case identified blueberry muffin lesions in a patient with foetal erythroblastosis and hypoxia secondary to severe maternal anaemia. [47] Other blueberry muffin rashes associated with anaemia include CEMH in the setting of Rh haemolytic disease of the newborn [48] and hereditary spherocytosis. [39,49] Blueberry muffin rashes have also been associated with congenital disorders such as Aicardi-Goutieres syndrome [50] and congenital non-ketotic hyperglycinemia.…”
Section: Cutaneous E X Tr Amedull Ary Haematop Oie S Ismentioning
confidence: 99%
“…[58] Another patient presented with truncal papules followed by facial subcutaneous nodules. [59] [44] Idiopathic myelofibrosis [52,53] Haemolytic disorder [39,49] Polycythemia vera [67] ABO incompatibility [45] Essential thrombocytopenia [68] Rh incompatibility [48] Primary hypertrophic osteoarthropathy [69] Twin-twin transfusion [45] Chronic myelogenous leukaemia [73] Maternal anaemia [47] Pilomatricoma [70] Inborn errors of metabolism [41,45] diagnosed as tri-lineage CEMH have been reported. [60,61] One patient who underwent splenectomy developed bullae at the surgical scar that spread centrifugally within days to cover the abdomen, groin, chest and back.…”
Section: Cutaneous E X Tr Amedull Ary Haematop Oie S Ismentioning
confidence: 99%
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