Fetal Hydrocephalus Caused by Cryptic Intraventricular Hemorrhage

Lategan, Belinda; Chodirker, Bernard N.; Bigio, Marc R. Del

doi:10.1111/j.1750-3639.2009.00293.x

Cited by 21 publications

(7 citation statements)

References 39 publications

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“…Pharmacological blockade with Ki16425, a receptor antagonist of LPA1 and LPA3, prevented the hydrocephalus [ 270 ]. The pathologic features in this mouse model resemble those in human fetal hydrocephalus caused by cryptic hemorrhage [ 271 ] and prematurity associated germinal matrix hemorrhage [ 272 ]. LPA from blood is postulated to disrupt the germinal zone.…”

Section: Resultsmentioning

confidence: 99%

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review

Bigio

Curzio

2015

Fluids Barriers CNS

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102

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Pharmacological interventions have been tested experimentally and clinically to prevent hydrocephalus and avoid the need for shunting beginning in the 1950s. Clinical trials of varied quality have not demonstrated lasting and convincing protective effects through manipulation of cerebrospinal fluid production, diuresis, blood clot fibrinolysis, or manipulation of fibrosis in the subarachnoid compartment, although there remains some promise in the latter areas. Acetazolamide bolus seems to be useful for predicting shunt response in adults with hydrocephalus. Neuroprotection in the situation of established hydrocephalus has been tested experimentally beginning more recently. Therapies designed to modify blood flow or pulsation, reduce inflammation, reduce oxidative damage, or protect neurons are so far of limited success; more experimental work is needed in these areas. As has been recommended for preclinical studies in stroke and brain trauma, stringent conditions should be met for preclinical studies in hydrocephalus.Electronic supplementary materialThe online version of this article (doi:10.1186/s12987-016-0025-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review

Bigio

Curzio

2015

Fluids Barriers CNS

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102

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“…However, intraventricular blood can also cause progressive ventricular dilatation even in the absence of a clinically obvious hemorrhage. In a series of 28 autopsies performed on fetuses from pregnancies that were terminated because of hydrocephalus, four fetuses were found to have evidence of cryptic microhemorrhage (red blood cells and hemosiderin-laden macrophages) within a structurally normal aqueduct [20]. Thus, some apparently idiopathic hydrocephalus may in fact be due to unrecognized prenatal intraventricular hemorrhage.…”

Section: Causes Of Hydrocephalusmentioning

confidence: 99%

Infantile hydrocephalus: A review of epidemiology, classification and causes

Tully¹,

Dobyns²

2014

European Journal of Medical Genetics

308

246

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Hydrocephalus is a common but complex condition caused by physical or functional obstruction of CSF flow that leads to progressive ventricular dilatation. Though hydrocephalus was recently estimated to affect 1.1 in 1,000 infants, there have been few systematic assessments of the causes of hydrocephalus in this age group, which makes it a challenging condition to approach as a scientist or as a clinician. Here, we review contemporary literature on the epidemiology, classification and pathogenesis of infantile hydrocephalus. We describe the major environmental and genetic causes of hydrocephalus, with the goal of providing a framework to assess infants with hydrocephalus and guide future research.

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“…Evidence of obstructive microhemorrhage in a structurally normal aqueduct is sometimes evident only upon autopsy. 19 Intraventricular hemorrhage has also been shown to induce nodules of neural progenitor cells within the ventricular system. 20 This mechanism could potentially explain the nodular obstruction seen in 3 children.…”

Section: Aqueductal Obstructionmentioning

confidence: 99%

Two Hundred Thirty-Six Children With Developmental Hydrocephalus: Causes and Clinical Consequences

et al. 2015

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Few systematic assessments of developmental forms of hydrocephalus exist. We reviewed MRIs and clinical records of patients with infancy-onset hydrocephalus. Among 411 infants, 236 had hydrocephalus with no recognizable extrinsic cause. These children were assigned to one of five subtypes and compared on the basis of clinical characteristics, developmental and surgical outcomes. At an average age of 5.3 years, 72% of children were walking independently and 87% could eat by mouth. 18% had epilepsy. Distinct patterns of associated malformations and syndromes were observed within each subtype. On average, children with aqueductal obstruction, cysts and encephaloceles had worse clinical outcomes than those with other forms of developmental hydrocephalus. 53% of surgically-treated patients experienced at least one shunt failure, but hydrocephalus associated with posterior fossa crowding required fewer shunt revisions. We conclude that each subtype of developmental hydrocephalus is associated with distinct clinical characteristics, syndromology, and outcomes, suggesting differences in underlying mechanisms.

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Fetal Hydrocephalus Caused by Cryptic Intraventricular Hemorrhage

Cited by 21 publications

References 39 publications

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review

Infantile hydrocephalus: A review of epidemiology, classification and causes

Two Hundred Thirty-Six Children With Developmental Hydrocephalus: Causes and Clinical Consequences

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