Fetal Hilar Cells and Leydig Cells in Early Pregnancy

Zondek, Lilly H.; Zondek, Theodor

doi:10.1159/000240920

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…We noticed them oc casionally in small numbers between the 15th and 20th week of gestation [Zondek and Zondek, 1976]. They have also been de scribed by other workers, particularly in later stages of development [Jaffe, 1931;Neu mann and Peter, 1931/32;Sauramo, 1954;Dhom, 1954/55, Slawik, 1958.…”

supporting

confidence: 82%

Ovarian Hilar Cells and Testicular Leydig Cells in Anencephaly

Zondek¹,

Zondek²

1983

Neonatology

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The presence of ovarian hilar cells in anencephaly has been investigated and compared with the presence of testicular Leydig cells in the same condition. The examination of 29 anencephalic ovaries and 49 controls showed that up to 36 weeks of gestation there was a preponderance of ovarian hilar cells in anencephalic monsters as compared with controls. Similar observations were made with regard to ovarian follicles which showed more pronounced maturational changes than controls. However, during the last month of gestation both these processes were more marked in the controls. These findings are in marked contrast to our previous observations on the testes in anencephalic monsters which showed significantly less Leydig cells than controls throughout the third trimester of pregnancy. It is assumed that these appearances are due to the fact that testes and ovaries are not strictly comparable structures and may, therefore, react in a different way to hormonal stimulation. This is of particular interest as the placental chorionic gonadotrophin levels which stimulate the development of testicular Leydig cells and, supposedly, the development of ovarian hilar cells are normal in anencephaly.

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confidence: 82%

Ovarian Hilar Cells and Testicular Leydig Cells in Anencephaly

Zondek¹,

Zondek²

1983

Neonatology

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“…We have reported elsewhere that the fetal ovary responds in a much less marked man ner than the fetal testis to stimulation by HCG from 10 to 20 weeks of gestation [Zon dek and Zondek, 1976]. This histological in vestigation which included determination of maternal plasma HCG levels, showed that high HCG levels appeared to have little effect on the formation of ovarian hilar cells which were present in small numbers in a propor tion of cases from the 13th week onwards.…”

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confidence: 79%

Fetal Ovarian Hilar Cells and Testicular Leydig Cells in Various Complications of Pregnancy

Zondek¹,

Zondek²

1984

Neonatology

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The presence of ovarian hilar cells in fetuses and neonates whose mothers suffered from complications of pregnancy such as toxaemia of pregnancy, diabetes mellitus, accidental haemorrhage, hydrops foetalis and multiple pregnancy, has been investigated and compared with the presence of testicular Leydig cells in similar conditions. The examination of ovaries from 62 cases with complications of pregnancy and of 113 controls showed that such conditions did not have an influence on the presence of hilar cells in the fetal and neonatal ovary. These findings are in marked contrast to our previous observations in the fetal and neonatal testis where the mean number of Leydig cells was found to be significantly raised in cases associated with complications of pregnancy as compared with controls. This further confirms our view, already expressed in a previous publication on the ovaries and testes of anencephalic monsters, that fetal and neonatal ovarian hilar cells and testicular Leydig cells are not strictly comparable, at least in their response to hormonal stimuli.

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