Fetal Hemoglobin in Diabetic Patients

Koskinen, Leena; Lahtela, Jorma; Koivula, Timo

doi:10.2337/diacare.17.8.828

Cited by 19 publications

(17 citation statements)

References 8 publications

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“…Moreover, we have observed that a decrease in HbA1c levels, and thus a better metabolic control, induced by intensive treatment in type 1 and type 2 diabetes subjects is associated with a decrease in HbF levels. An increased prevalence of high HbF levels ranging from 13 to 38% of cases has been reported in type 1 diabetes subjects (6)(7)(8). Our data are in agreement with these reports.…”

Section: Discussionsupporting

confidence: 83%

“…It has been suggested that high HbF levels could be related to a direct effect of insulin therapy (7,12). However, our data do not agree with this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…During the first year of life, HbF is gradually replaced by hemoglobin A, and only small amounts of HbF (<1.0%) can be found in adult life (5). HbF levels were shown to be increased in some subjects with type 1 diabetes (6)(7)(8), but data on HbF levels in type 1 diabetes are scarce. Moreover, no data are available for subjects with type 2 diabetes, and the correlation of HbF levels with the quality of metabolic control in diabetic subjects remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Fetal hemoglobin levels are related to metabolic control in diabetic subjects

Pardini¹,

Victoria

Pieroni

et al. 1999

Braz J Med Biol Res

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We have investigated the relationship between fetal hemoglobin (HbF) levels and metabolic control in subjects with insulin-dependent (N = 79) and non-insulin-dependent diabetes mellitus (N = 242). HbF and hemoglobin A1c (HbA1c) levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P<0.0001), and were significantly higher in type 1 than in type 2 diabetes subjects. Lower levels of HbA1c and HbF were observed in type 2 diabetes subjects treated by diet, intermediate levels in those treated with oral hypoglycemic agents, and higher levels in those treated with insulin. HbF and HbA1c levels were correlated in type 1 diabetes (R 2 = 0.57, P<0.0001) and type 2 diabetes (R 2 = 0.58, P<0.0001) subjects. Following intense treatment, twelve diabetic patients showed significant improvement both in HbA1c and HbF values. We conclude that increased HbF levels reflect poor metabolic control in subjects with diabetes mellitus.

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Section: Discussionsupporting

confidence: 83%

“…It has been suggested that high HbF levels could be related to a direct effect of insulin therapy (7,12). However, our data do not agree with this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fetal hemoglobin levels are related to metabolic control in diabetic subjects

Pardini¹,

Victoria

Pieroni

et al. 1999

Braz J Med Biol Res

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“…Previous studies that have examined differences by ethnicity have found significant variation in rates of medical insurance coverage (42). Other studies of patients with diabetes have found that most have some form of medical insurance and that African Americans and non-Hispanic whites have similar rates of coverage (43).…”

Section: Discussionmentioning

confidence: 99%

Disparities in HbA1c Levels Between African-American and Non-Hispanic White Adults With Diabetes

et al. 2006

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OBJECTIVE—Among individuals with diabetes, a comparison of HbA1c (A1C) levels between African Americans and non-Hispanic whites was evaluated. Data sources included PubMed, Web of Science, the Cumulative Index to Nursing and Allied Health, the Cochrane Library, the Combined Health Information Database, and the Education Resources Information Center. RESEARCH DESIGN AND METHODS—We executed a search for articles published between 1993 and 2005. Data on sample size, age, sex, A1C, geographical location, and study design were extracted. Cross-sectional data and baseline data from clinical trials and cohort studies for African Americans and non-Hispanic whites with diabetes were included. Diabetic subjects aged <18 years and those with pre-diabetes or gestational diabetes were excluded. We conducted a meta-analysis to estimate the difference in the mean values of A1C for African Americans and non-Hispanic whites. RESULTS—A total of 391 studies were reviewed, of which 78 contained A1C data. Eleven had data on A1C for African Americans and non-Hispanic whites and met selection criteria. A meta-analysis revealed the standard effect to be 0.31 (95% CI 0.39–0.25). This standard effect correlates to an A1C difference between groups of ∼0.65%, indicating a higher A1C across studies for African Americans. Grouping studies by study type (cross-sectional or cohort), method of data collection for A1C (chart review or blood draw), and insurance status (managed care or nonmanaged care) showed similar results. CONCLUSIONS—The higher A1C observed in this meta-analysis among African Americans compared with non-Hispanic whites may contribute to disparity in diabetes morbidity and mortality in this population.

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“…Several investigators suggested that increased prevalence of elevated HbF may be associated with poor glycemic control [7,8]. On the other hand, another group of researchers reported that no significant differences were observed in glycemic control and the duration of diabetes between patients with high or low HbF levels [9]. …”

Section: Introductionmentioning

confidence: 99%