2013
DOI: 10.1111/ijlh.12165
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Fetal hemoglobin and alpha thalassemia modulate the phenotypic expression of HbSD‐Punjab

Abstract: HbF reduced the frequency of VOC but had no influence on the hemolytic markers in HbSD. HbSD with alpha thalassemia was associated with hypohromic and microcytic features of red blood cells.

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Cited by 13 publications
(14 citation statements)
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“…This clinical course is similar to that observed in children with homozygous Hb SS disease as has already been reported in other studies 10, 11, 16, 17, 25. Oberoi et al evaluated ten patients aged between 1 and 19 years.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…This clinical course is similar to that observed in children with homozygous Hb SS disease as has already been reported in other studies 10, 11, 16, 17, 25. Oberoi et al evaluated ten patients aged between 1 and 19 years.…”
Section: Discussionsupporting
confidence: 87%
“…This association has been described in patients with Hb SS disease and has been explained by the fact that red blood cells with larger quantities of Hb F possess lower levels of Hb S; therefore, they have a lower chance of sickling, and as a result, a lower probability of experiencing clinical manifestations 28 . Patel et al found higher Hb F concentrations to be associated with a lower frequency of acute pain crises in the 42 patients with Hb S/D-Punjab disease 25 . Meanwhile, three other studies failed to find this association; however, they did include much smaller sample populations than Patel et al The other studies included five, nine, and 15 patients, respectively 9, 10, 17…”
Section: Discussionmentioning
confidence: 99%
“…A severidade clínica depende também da expressão fenotípica da hemoglobina variante. 9,15,16,17 A hemoglobinopatia SD foi descrita pela primeira vez em 1966 em um homem com caracterís-ticas caucasoides que tinha diagnóstico de anemia falciforme (Hb SS). 18 …”
Section: Resultadounclassified
“…Researchers from India and the Middle East are the main authors of the few papers about Hb SD-Punjab; there are less data published about the association Hb S-Hb KB 21, 27, 28, 29, 34, 36, 37, 38, 39, 40, 41. By studying two different groups of patients with Hb SD patterns, specifically Hb SD-Punjab and Hb S-Hb KB, Rezende et al not only published important clinical data about the coinheritance of two rare Hb but also pointed out the importance of this differential diagnosis 15 …”
mentioning
confidence: 99%