Fetal Heart Rate Reactivity Differs by Women's Psychiatric Status: An Early Marker for Developmental Risk?

Monk, Catherine; Sloan, Richard P.; Myers, Michael; Ellman, Lauren M.; Werner, Elizabeth; Jeon, Jiyeon; Tager, Felice A.; Fifer, William P.

doi:10.1097/00004583-200403000-00009

Cited by 115 publications

(130 citation statements)

References 26 publications

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“…All maternal psychological events must be physiologically transduced to the fetus and the observed associations between responses of individual maternal-fetal pairs suggest some mediation between maternal autonomic measures and FHR parameters. However, the magnitudes of the detected associations between maternal autonomic measures and fetal cardiac patterns are quite modest but are consistent with those observed elsewhere under both elicited (DiPietro et al, 2003;Monk et al, 2004) and baseline (DiPietro, Irizarry, Costigan, & Gurewitsch, 2004) conditions. Similarly, although there was a significant association between the degree of cortisol decline and suppression of movement, as well as a trend association between cortisol decline and FHR variability change, the strongest association accounted for only 9% of the variance.…”

Section: Discussionsupporting

confidence: 89%

“…Three studies report fetal responses to maternal arousal induced by a common cognitive challenge that incurs a sympathetic response, the Stroop Color Word Test. These include increased variability in heart rate concomitant with suppression of motor activity (DiPietro, Costigan, & Gurewitsch, 2003) and increased fetal heart rate in fetuses of women with high trait anxiety or depression (Monk et al, 2000;Monk et al, 2004).…”

mentioning

confidence: 99%

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Fetal responses to induced maternal relaxation during pregnancy

DiPietro

Costigan

Nelson

et al. 2008

Biological Psychology

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Fetal responses to induced maternal relaxation during the 32 nd week of pregnancy were recorded in 100 maternal-fetal pairs using a digitized data collection system. The 18-minute guided imagery relaxation manipulation generated significant changes in maternal heart rate, skin conductance, respiration period, and respiratory sinus arrhythmia. Significant alterations in fetal neurobehavior were observed, including decreased fetal heart rate (FHR), increased FHR variability, suppression of fetal motor activity (FM), and increased FM-FHR coupling. Attribution of the two fetal cardiac responses to the guided imagery procedure itself, as opposed to simple rest or recumbency, is tempered by the observed pattern of response. Evaluation of correspondence between changes within individual maternal-fetal pairs revealed significant associations between maternal autonomic measures and fetal cardiac patterns, lower umbilical and uterine artery resistance and increased FHR variability, and declining salivary cortisol and FM activity. Potential mechanisms that may mediate the observed results are discussed.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Fetal responses to induced maternal relaxation during pregnancy

DiPietro

Costigan

Nelson

et al. 2008

Biological Psychology

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“…Maternal depression during pregnancy may have a profound effect on offspring development. 87 For example, maternal psychologic symptoms lead to distinguishable differences in fetal heart rate response to stress by the end of pregnancy, 88 such that fetuses of more anxious mothers showed significant increases in heart rate during a stressor, whereas fetuses of less anxious mothers showed nonsignificant decreases in heart rate. Thus, even before birth, fetuses of more anxious mothers show greater stress reactivity than those of nonanxious mothers.…”

Section: Infant Developmentmentioning

confidence: 99%

Failed Lactation and Perinatal Depression: Common Problems with Shared Neuroendocrine Mechanisms?

Stuebe

Grewen

Pedersen

et al. 2012

Journal of Women's Health

117

106

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In the early postpartum period, mother and infant navigate a critical neuroendocrine transition from pregnancy to lactation. Two major clinical problems that occur during this transition are failed lactation and perinatal mood disorders. These disorders often overlap in clinical settings. Failed lactation is common. Although all major medical organizations recommend 6 months of exclusive breastfeeding, only 13% of women in the United States achieve this recommendation. Perinatal mood disorders affect 10% of mothers, with substantial morbidity for mother and child. We hypothesize that shared neuroendocrine mechanisms contribute to both failed lactation and perinatal mood disorders. In this hypothesis article, we discuss data from both animal models and clinical studies that suggest neuroendocrine mechanisms that may underlie these two disorders. Research to elucidate the role of these underlying mechanisms may identify treatment strategies both to relieve perinatal depression and to enable women to achieve their infant feeding goals.

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“…None of the women in the study took psychotropic medication during pregnancy. In the 3 rd trimester, they made a second trip to the laboratory for a psychophysiology session, reported elsewhere [23]. Women completed questionnaires assessing current feelings of depression (CES-D) [24] and state and trait anxiety (STAI) [25].…”

Section: Antenatal Psychiatric Assessmentmentioning

confidence: 99%