Fetal Growth Restriction and Schizophrenia: A Swedish Twin Study

Nilsson, Emma; Stålberg, Gabriella; Lichtenstein, Paul; Cnattingius, Sven; Olausson, Petra Otterblad; Hultman, Christina M.

doi:10.1375/twin.8.4.402

Cited by 43 publications

(23 citation statements)

References 30 publications

(32 reference statements)

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“…One possibility is that the mothers of the cases may also have had personality disorder (Torgersen et al, 2008), and thus increase the risk of birth complications by abuse of substances or through suboptimal adherence to prenatal health care. On the other hand, studies on discordant monozygotic twins suggest that the associations between perinatal factors and schizophrenia (Nilsson et al, 2005) and attention-deficit/hyperactivity symptoms (Hultman et al, 2007) remain after controlling for genetic and early environmental factors. Other designs will be necessary to explore the role of other potential mediating factors including head injury and childhood trauma (Thapar & Rutter 2009).…”

Section: Discussionmentioning

confidence: 99%

Perinatal Risk Factors in Offenders with Severe Personality Disorder: A Population-based Investigation

Fazel¹,

Bakiyeva²,

Cnattingius³

et al. 2012

Journal of Personality Disorders

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Although perinatal factors are associated with the development of several psychiatric disorders, it is unknown whether these factors are linked with personality disorder. Cases of personality disorder were drawn from a national registry of all forensic psychiatric evaluations (n=150). Two control groups were used: 1. A sample of forensic evaluations without any psychiatric disorder (n=97) allowing for a nested case-control investigation; 2: A population-based sample matched by age and gender with no history of psychiatric hospitalization (n=1498). Prematurity (<37 weeks of completed gestation) was significantly associated with a diagnosis of personality disorder, both in the nested and the population-based case-control comparisons with adjusted odds ratios (OR) for this risk factors ranging from 2 to 4. Asphyxia (adjusted OR=2.4, 95% CI: 1.4-4.1) and complicated delivery (adjusted OR=1.5, 1.0-2.1) were associated with personality disorder in the population-based study, and the former remained significant in multivariate models. Overall, perinatal complications were found to be associated with a later diagnosis of personality disorder in this selected sample. As with other psychiatric disorders where such associations have been demonstrated, changes during the perinatal period may lead to abnormal brain development and function.

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Section: Discussionmentioning

confidence: 99%

Perinatal Risk Factors in Offenders with Severe Personality Disorder: A Population-based Investigation

Fazel¹,

Bakiyeva²,

Cnattingius³

et al. 2012

Journal of Personality Disorders

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“…Low birth weight has been implicated in risk for several other psychiatric disorders, including schizophrenia, 28,29 attention-deficit/hyperactivity disorder (ADHD), 9,10,16,17,30 and eating disorders. 31 Research in these areas has not so far tested a fetal origins hypothesis against alternatives, to our knowledge.…”

Section: Indings From Studies Thatmentioning

confidence: 99%

Prediction From Low Birth Weight to Female Adolescent Depression

Costello¹,

Worthman²,

Erkanli³

et al. 2007

Arch Gen Psychiatry

213

143

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Context: Low birth weight (LBW) predicts later-onset hypertension and diabetes mellitus. Its role as a predictor of depression is unclear.Objectives: To examine whether LBW predicts depression in male and female children and adolescents and to compare the following 2 hypotheses: Low birth weight is one among several perinatal, childhood, and adolescent risk factors for depression (biopsychosocial hypothesis). Low birth weight is a marker for poor intrauterine conditions that provoke adjustments in fetal development, with long-term consequences for stress response (fetal programming hypothesis).Design: A representative population-based sample from an 11-county area in western North Carolina was assessed annually for psychiatric disorders between the ages of 9 and 16 years. We tested the prediction from LBW and depression in models that included LBW only, LBW plus other prenatal and perinatal adversities, LBW plus significant perinatal and childhood adversities, and LBW plus significant perinatal and childhood adversities and adolescent correlates.Setting: Academic research.Participants: There were 1420 participants, of whom 49% were female.Main Outcome Measure: Cumulative prevalence of DSM-IV depressive disorder at 1 assessment or more during childhood (age range, 9-12 years) and during adolescence (age range, 13-16 years). Results:The cumulative prevalence of depression among adolescent girls with LBW was 38.1% (95% confidence interval [CI], 16.3%-66.0%) compared with 8.4% (95% CI, 5.2%-13.3%) among adolescent girls with normal birth weight. Rates among children and adolescent boys did not exceed 4.9%. In adolescence, there was a significant interaction between LBW and sex (odds ratio, 0.2 [95% CI, 0.1-0.5]; PϽ.001). Low birth weight predicted female adolescent depression after controlling for other perinatal, childhood, and adolescent adversities. Girls with LBW and normal birth weight with no adversities had no adolescent depression, but each additional adversity increased the risk of in girls with LBW more than in girls with normal birth weight. Low birth weight did not predict other psychiatric disorders in either sex.Conclusions: Low birth weight predicts depression in adolescent girls but not boys. Data support fetal programming over the biopsychosocial hypothesis, suggesting vulnerability to adversities in girls with LBW after puberty.

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“…In addition to cardiometabolic sequelae, low birth weight has also been related to increased risk of death from infectious causes,6 altered immune function, an increased risk of asthma and atopic dermatitis,7 and neurodevelopmental disorders such as attention deficit hyperactivity disorder8 and schizophrenia 9. The importance of the early life environment in influencing later disease risk has been highlighted by a recent analysis showing that the greater the number of adverse early life risk factors an individual is exposed to, the greater the risk of overweight and obesity in childhood 10…”

Section: Adverse Environments In Uteromentioning

confidence: 99%

What a general paediatrician needs to know about early life programming

Williams

Drake

2015

Arch Dis Child

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The process whereby early exposure to an adverse environment has an influence on later life outcomes has been called ‘early life programming’. While epidemiological evidence for this has been available for decades, only in recent years have the mechanisms, in particular epigenetic modifications, for this process begun to be elucidated. We discuss the evidence for early life programming, the possible mechanisms, how effects may be transmitted across generations, and conclude by looking at some examples relevant to general paediatrics.

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Fetal Growth Restriction and Schizophrenia: A Swedish Twin Study

Cited by 43 publications

References 30 publications

Perinatal Risk Factors in Offenders with Severe Personality Disorder: A Population-based Investigation

Perinatal Risk Factors in Offenders with Severe Personality Disorder: A Population-based Investigation

Prediction From Low Birth Weight to Female Adolescent Depression

What a general paediatrician needs to know about early life programming

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