Fetal Growth Restriction and Methylation of Growth-Related Genes in the Placenta

Xiao, Xirong; Zhao, Yan; Jin, Rong; Chen, Jiao; Xiu, Wang; Baccarelli, Andrea A.; Zhang, Yunhui

doi:10.2217/epi.15.101

Cited by 49 publications

(32 citation statements)

References 38 publications

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“…Epigenetics (Xiao et al, 2016) and gene expression (Buffat et al, 2007;Madeleneau et al, 2015) reprogramming play a central role in IUGR. However, the pathophysiological connections between these two fields of high-throughput analyses have only recently begun to be studied (Ding and Cui, 2017).…”

Section: Introductionmentioning

confidence: 99%

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

et al. 2020

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Intrauterine Growth Restriction (IUGR) affects 8% of newborns and increases morbidity and mortality for the offspring even during later stages of life. Single omics studies have evidenced epigenetic, genetic, and metabolic alterations in IUGR, but pathogenic mechanisms as a whole are not being fully understood. An in-depth strategy combining methylomics and transcriptomics analyses was performed on 36 placenta samples in a case-control study. Data-mining algorithms were used to combine the analysis of more than 1,200 genes found to be significantly expressed and/or methylated. We used an automated text-mining approach, using the bulk textual gene annotations of the discriminant genes. Machine learning models were then used to explore the phenotypic subgroups (premature birth, birth weight, and head circumference) associated with IUGR. Gene annotation clustering highlighted the alteration of cell signaling and proliferation, cytoskeleton and cellular structures, oxidative stress, protein turnover, muscle development, energy, and lipid metabolism with insulin resistance. Machine learning models showed a high capacity for predicting the sub-phenotypes associated with IUGR, allowing a better description of the IUGR pathophysiology as well as key genes involved.

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Section: Introductionmentioning

confidence: 99%

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

et al. 2020

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“…It is defined as having a weight at two standard deviations (tenth percentile) below that of a normal fetus, or at <2.5 kg after 37 weeks of pregnancy (Seravalli and Baschat, 2015). The cause for abnormal fetal size may be either extrinsic (placenta, matrix) or intrinsic to the fetus itself (Lewis et al, 2016;Xiao et al, 2016). Studies have shown that FGR is the second leading cause of deaths among fetuses during the perinatal period, with a threefold increase in mortality rates as compared to that of a normal neonate (Boulet et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction

2016

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ABSTRACT. Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and categorized the neonates into the FGR, appropriate for gestational age, and large for gestational age groups. Birth weight, body length, head circumference, body mass index (BMI), and Rohrer's body index of the newborns were measured. Serum folic acid, vitamin B12, and homocysteine levels were measured in mothers during the first three days of their hospital stay. Results showed that the FGR group exhibited reduced folic acid and vitamin B12 levels and elevated homocysteine levels than those in the other two groups. Folic acid and vitamin B12 levels were positively correlated with birth weight, head circumference, and BMI, whereas homocysteine level was negatively correlated with these variables. The FGR ratio in the folic acid and vitamin B12 deficiency group was higher than that in the sufficiency group (χ 2 = 4.717 and 4.437, P = 0.029 and 0.035, respectively). In addition, elevated homocysteine was associated with FGR (χ 2 = 5.366, P = 0.021). In conclusion, we found that folic acid and vitamin B12 deficiency was associated with elevated homocysteine levels, which may increase susceptibility to FGR.

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“…www.nature.com/scientificreports www.nature.com/scientificreports/ performed in rather small scale settings, and were more focused on intrauterine growth restriction (IUGR) or SGA birth outcomes [30][31][32][33] . Bourque et al, using 35 placenta samples, showed no difference in LINE-1 methylation comparing intrauterine growth restricted newborns to newborns with normal birth weight 30 .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, investigating DNA methylation levels on a global scale might facilitate getting first insights into epigenetic mechanisms of complex phenotypes 28,29 . However, studies investigating correlations between global DNA methylation and birth weight so far were only performed using rather small sample sizes [30][31][32][33] .…”

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confidence: 99%

Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation

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Hasan

et al. 2020

Sci Rep

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Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DnA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DnA methylation are lacking. the aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher global placental DNA methylation compared to appropriate for gestational age (AGA; p < 0.001). ANCOVA analyses adjusted for known factors impacting on DNA methylation demonstrated an independent association between placental global DNA methylation and LGA births (p < 0.001). Tertile stratification according to global placental DNA methylation levels revealed a significantly higher frequency of LGA births in the third tertile. Furthermore, a multiple logistic regression analysis corrected for known factors influencing birth weight highlighted an independent positive association between global placental DNA methylation and the frequency of LGA births (p = 0.001).

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Fetal Growth Restriction and Methylation of Growth-Related Genes in the Placenta

Cited by 49 publications

References 38 publications

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

Data-Mining Approach on Transcriptomics and Methylomics Placental Analysis Highlights Genes in Fetal Growth Restriction

Blood folic acid, vitamin B12, and homocysteine levels in pregnant women with fetal growth restriction

Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation

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