Fetal Growth, Preterm Birth, Neonatal Stress and Risk for CNS Tumors in Children: A Nordic Population- and Register-Based Case-Control Study

Schmidt, Lene Skytthe Kaarsberg; Schüz, Joachim; Lähteenmäki, Päivi; Träger, Catarina; Stokland, Tore; Gustafson, Göran; Hjalgrim, Lisa Lyngsie; Sehested, Astrid; Johansen, Christoffer; Schmiegelow, Kjeld

doi:10.1158/1055-9965.epi-09-1273

Cited by 49 publications

(74 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 In our expanded data set, we found an increased risk for CNS tumors in children with birth weight .4500 g but no associations with SGA or LGA.…”

Section: Figures 1 and 2 Andmentioning

confidence: 56%

“…8,9 The strongest effect was observed in the youngest age groups and persisted up to age 10 years. We also found an increasing risk with increasing head circumference but only among children diagnosed within the first year of life (except for the Norwegian data).…”

Section: Figurementioning

confidence: 96%

“…[5][6][7] Earlier Nordic population-based studies have also shown that increased head circumference is positively associated with childhood brain cancer, suggesting that brain pathologic conditions originate in fetal life. 8,9 Studies of pregnancy risk factors are made difficult by the low relative frequency of different childhood tumors. Pooling data from birth and cancer registries in several countries, however, makes it possible to achieve a sufficient study size.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Fetal Growth and Childhood Cancer: A Population-Based Study

et al. 2013

View full text Add to dashboard Cite

OBJECTIVE: The etiology of childhood cancers is largely unknown. Studies have suggested that birth characteristics may be associated with risk. Our goal was to evaluate the risk of childhood cancers in relation to fetal growth. METHODS: We conducted a case-control study nested within Nordic birth registries. The study included cancer cases diagnosed in Denmark, Finland, Norway, and Sweden among children born from 1967 to 2010 and up to 10 matched controls per case, totaling 17 698 cases and 172 422 controls. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were derived from conditional logistic regression. RESULTS: Risks of all childhood cancers increased with increasing birth weight (Ptrend ≤ .001). Risks of acute lymphoid leukemia and Wilms tumor were elevated when birth weight was >4000 g and of central nervous system tumors when birth weight was >4500 g. Newborns large for gestational age were at increased risk of Wilms tumor (OR: 2.1 [95% CI: 1.2–3.6]) and connective/soft tissue tumors (OR: 2.1 [95% CI: 1.1–4.4]). In contrast, the risk of acute myeloid leukemia was increased among children born small for gestational age (OR: 1.8 [95% CI: 1.1–3.1]). Children diagnosed with central nervous system tumors at <1 year of age had elevated risk with increasing head circumference (Ptrend < .001). Those with head circumference >39 cm had the highest risk (OR: 4.7 [95% CI: 2.5–8.7]). CONCLUSIONS: In this large, Nordic population-based study, increased risks for several childhood tumors were associated with measures of fetal growth, supporting the hypothesis that tumorigenesis manifesting in childhood is initiated in utero.

show abstract

“…9 In our expanded data set, we found an increased risk for CNS tumors in children with birth weight .4500 g but no associations with SGA or LGA.…”

Section: Figures 1 and 2 Andmentioning

confidence: 56%

Section: Figurementioning

confidence: 96%

mentioning

confidence: 99%

See 1 more Smart Citation

Fetal Growth and Childhood Cancer: A Population-Based Study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Knowledge about the aetiology of central nervous system (CNS) tumours in children is sparse; however, several studies indicate that the pathogenic process of CNS tumours in children is initiated prenatally (Linet et al, 1996;Fear et al, 2001;Harder et al, 2008;Schmidt et al, 2010). Furthermore, a few studies indicate that exposure to infectious agents around the time of birth or in early childhood might modulate the risk for CNS tumours (Linet et al, 1996;Linos et al, 1998;Fear et al, 2001;McNally et al, 2002;Hoffman et al, 2007).…”

mentioning

confidence: 99%

Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth

et al. 2010

View full text Add to dashboard Cite

BACKGROUND: An infective, mostly viral basis has been found in different human cancers. To test the hypothesis of a possible infectious aetiology for central nervous system (CNS) tumours in children, we investigated the associations with proxy measures of exposure to infectious disease. METHODS: In a large case -control study nested in the populations of Denmark, Norway, Sweden, and Finland of 4.4 million children, we studied the association of birth order and seasonal variation of birth with subsequent risk for CNS tumours. We identified 3983 children from the national cancer registries, and information on exposure was obtained from the high-quality national administrative health registries. We investigated the association between childcare attendance during the first 2 years of life and the risk for CNS tumours in a subset of Danish children with CNS tumours, using information from the Danish Childcare database. RESULTS: We observed no association between birth order and risk of CNS tumours overall (odds ratio (OR) for second born or later born vs first born, 1.03; 95% confidence interval (CI), 0.96 -1.10) or by histological subgroup, and children with CNS tumours did not show a seasonal variation of birth that was distinct from that of the background population. Childcare attendance compared with homecare showed a slightly increased OR (1.29; 95% CI, 0.90 -1.86) for CNS tumours, with the highest risk observed in children attending a crèche. The strongest association was observed for embryonal CNS tumours. We found no effect of age at enrolment or duration of enrolment in childcare. CONCLUSION: These results do not support the hypothesis that the burden of exposure to infectious disease in early childhood has an important role in the aetiology of paediatric CNS tumours.

show abstract

“…The effect of birth size characteristics, such as birth weight, fetal growth, gestational age, and head circumference, on brain tumor risk has mainly been investigated among children (1)(2)(3)(4)(5)(6)(7)(8). Although previous studies have shown that children born with a high birth weight had an elevated risk of brain tumors (1)(2)(3)(4), others have found no association (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Birth Size Characteristics and Risk of Brain Tumors in Early Adulthood: Results from a Swedish Cohort Study

Tettamanti

Ljung

Mathiesen

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Despite extensive research on the effect of birth size characteristics on childhood brain tumors, very few studies have evaluated the effect of birth size characteristics on the risk of adult brain tumor, and they have provided inconsistent results.Methods: All individuals born in Sweden between 1973 and 1995 who were still alive and cancer free at their 15th birthday were included in the study (n ¼ 2,032,727). At the end of the study period (December 31, 2010), the study participants were 15 to 37 years old. Incident cases of primary brain tumors were identified through the Swedish Cancer Register.Results: No association was observed between any birth size characteristics and glioma, although an indication of increased glioma risk associated with high birth weight, or being large for gestational age at birth, was found among men [relative risk

show abstract

Fetal Growth, Preterm Birth, Neonatal Stress and Risk for CNS Tumors in Children: A Nordic Population- and Register-Based Case-Control Study

Cited by 49 publications

References 51 publications

Fetal Growth and Childhood Cancer: A Population-Based Study

Fetal Growth and Childhood Cancer: A Population-Based Study

Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth

Birth Size Characteristics and Risk of Brain Tumors in Early Adulthood: Results from a Swedish Cohort Study

Contact Info

Product

Resources

About