Fetal growth and maternal exposure to particulate air pollution -- More marked effects at lower exposure and modification by gestational duration

Winckelmans, Ellen; Cox, Bianca; Martens, Evelyne; Fierens, Frans; Nemery, Benoît; Nawrot, Tim S.

doi:10.1016/j.envres.2015.05.015

Cited by 44 publications

(24 citation statements)

References 46 publications

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“…It has been shown that there is a relationship between air quality and birth weight [31][32][33]. The maternal exposure to PM, in our study, did not cause low birth weight.…”

Section: Discussionsupporting

confidence: 53%

Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

Miranda

Franco

Previate

et al. 2018

Cell Physiol Biochem

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Background/Aims: Particulate matter (PM) is an important risk factor for immunological system imbalance due to its small size, which can reach more distal regions of the respiratory tract, independently of its chemical composition. Some studies have suggested that PM exposure is associated with an increased incidence of diabetes, especially in industrialized urban regions. However, studies regarding the effects of PM exposure during perinatal life on glucose metabolism are limited. We tested whether exposure to PM from an urban area with poor air quality during pregnancy and lactation could cause short- and long-term dysfunction in rat offspring. Methods: Samples of < 10 µm PM were collected in an urban area of Cotonou, Benin (West Africa), and reconstituted in corn oil. Pregnant Wistar rats received 50 µg PM/day by gavage until the end of lactation. After birth, we analyzed the dams’ biochemical parameters as well as those of their male offspring at 21 and 90 days of age. Results: The results showed that PM exposure did not lead to several consequences in dams; however, the male offspring of both ages presented an increase of approximately 15% in body weight. Although the blood glucose levels remained unchanged, the insulin levels were increased 2.5- and 2-fold in PM exposure groups of both ages, respectively. HOMA-IR and HOMA-β were also increased at both ages. We also demonstrated that the number, islet area and insulin immunodensity of pancreatic islets were significantly increased at both ages from PM exposure. Conclusion: Our data show that chronic PM exposure by the oral route during perinatal life in rats leads to glucose dyshomeostasis in male offspring both in early and later life. Thus, we suggest that an ambience with poor air quality, mainly where traffic is dense, can contribute to an increase in metabolic disease incidence.

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“…It has been shown that there is a relationship between air quality and birth weight [31][32][33]. The maternal exposure to PM, in our study, did not cause low birth weight.…”

Section: Discussionsupporting

confidence: 53%

Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

Miranda

Franco

Previate

et al. 2018

Cell Physiol Biochem

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“…Some other studies (e.g. New Jersey, Europe, South Korea) had simpler categories such as high school or less (12 years) and more than high school (>12 years) (Yi et al 2010, Faiz et al 2013 or low, medium, and high education (Winckelmans et al 2015). Finer categorization of education level appears to be useful to examine if the risk in infants of mothers with mid-level (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies using birth certificate data based on electronic databases (Coker et al 2016, Morelli et al 2016. One study used information at birth that was obtained from the official perinatal forms sent to the responsible nonprofit association for perinatal data collection (Winckelmans et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Risk of particulate matter on birth outcomes in relation to maternal socio-economic factors: a systematic review

Heo

Fong

Bell

2019

Environ. Res. Lett.

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A growing number of studies provide evidence of an association between exposure to maternal air pollution during pregnancy and adverse birth outcomes including low birth weight (LBW) and preterm birth. Prevention of these health effects of air pollution is critical to reducing the adverse infant outcomes, which can have impacts throughout the life course. However, there is no consensus on whether the association between air pollution exposure and birth outcomes varies by maternal risk factors including demographic characteristics and socio-economic status (SES). Such information is vital to understand potential environmental health disparities. Our search found 859 unique studies, of which 45 studies met our inclusion criteria (January 2000-July 2019). We systematically reviewed the 45 identified epidemiologic studies and summarized the results on effect modifications by maternal race/ethnicity, educational attainment, income, and area-level SES. We considered adverse birth outcomes of preterm birth, LBW, small for gestational age (SGA), and stillbirth. Suggestive evidence of higher risk of particulate matter (PM) in infants of African-American/black mothers than infants of other women was found for preterm birth and LBW. We found weak evidence that PM risk was higher for infants of mothers with lower educational attainment for preterm birth and LBW. Due to the small study numbers, we were unable to conclude whether effect modification is present for income, occupation, and area-level SES, and additional research is needed. Furthermore, adverse birth outcomes such as SGA and stillbirth need more study to understand potential environmental justice issues regarding the impact of PM exposure during pregnancy on birth outcomes.

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“…In 1990, Barker hypothesized that adult diseases are already programmed by the environment in fetal and infant life (Barker 1990). Indeed, recent findings suggest that indoor and outdoor exposure to environmental PM during in utero life is associated with adverse fetal outcomes including lower birth weight (Farmer et al 2014; Glinianaia et al 2004; Winckelmans et al 2015). Underlying biological mechanisms involved in PM induced adverse health outcomes remain largely unknown, but indications of the involvement of inflammatory processes and oxidative stress are rising (Farmer et al 2014; Proietti et al 2013; Risom et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIR ON AGE Birth Cohort Study

Martens

Gouveia

Madhloum

et al. 2017

Environ Health Perspect

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Background:As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology.Objectives:We studied the association between in utero PM2.5 (particulate matter with aerodynamic diameter < 2.5 μm) exposure and oxylipin profiles in newborns.Methods:Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX), and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort. Principal component (PC) analysis and multiple regression models were used to estimate associations of in utero PM2.5 exposure with oxylipin pathways and individual metabolites.Results:A principal component representing the 5-LOX pathway (6 metabolites) was significantly positively associated with PM2.5 exposure during the entire (multiple testing–adjusted q-value = 0.05) and second trimester of pregnancy (q = 0.05). A principal component representing the 12/15-LOX pathway (11 metabolites) was positively associated with PM2.5 exposure during the second trimester of pregnancy (q = 0.05). PM2.5 was not significantly associated with the COX pathway during any time period. There was a positive but nonsignificant association between second-trimester PM2.5 and the CYP pathway (q = 0.16).Conclusion: In utero exposure to particulate matter, particularly during the second trimester, was associated with differences in the cord blood levels of metabolites derived from the lipoxygenase pathways. These differences may indicate an effect of air pollution during in utero life on the inflammatory state of the newborn at birth. Oxylipins may be important mediators between early life exposures and health outcomes later in life.Citation:Martens DS, Gouveia S, Madhloum N, Janssen BG, Plusquin M, Vanpoucke C, Lefebvre W, Forsberg B, Nording M, Nawrot TS. 2017. Neonatal cord blood oxylipins and exposure to particulate matter in the early-life environment: an ENVIRONAGE birth cohort study. Environ Health Perspect 125:691–698; http://dx.doi.org/10.1289/EHP291

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Fetal growth and maternal exposure to particulate air pollution -- More marked effects at lower exposure and modification by gestational duration

Cited by 44 publications

References 46 publications

Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

Risk of particulate matter on birth outcomes in relation to maternal socio-economic factors: a systematic review

Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIR ON AGE Birth Cohort Study

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