Fetal Gallstones

Munjuluri, Nalini; Elgharaby, Nader; Acolet, Dominique; Kadir, Rezan A.

doi:10.1159/000085077

Cited by 20 publications

(20 citation statements)

References 14 publications

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“…In other 4 patients disappearance of gallstones was observed, but three of them had a pseudolithiasis (following antibiotic-therapy with ceftriaxone) and one had fetal gallstones. Since these conditions are described as auto-resolving diseases [20][21][22][23] , the disappearance was not There were no post-operative complication and in no case residual cholelithiasis or recurrence of gallstones during the follow-up were observed. In three patients recurrence of clinical symptoms after treatment (post-cholecystectomy syndrome) was described.…”

Section: Patients Observed At Medical Departmentsmentioning

confidence: 99%

Management of cholelithiasis in Italian children: A national multicenter study

Corte¹,

Falchetti²,

Nebbia³

et al. 2008

WJG

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development of complications was reported. CONCLUSION:The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones. INTRODUCTIONIn the last years following the extensive use of ultrasound scanning an increasing number of children with cholelithiasis has been identified. In a population based study, prevalence of gallstones and biliary sludge in children was of 1.9% and 1.46%, respectively [1] . In an analogue study, performed in Italian adults, the overall prevalence of gallstones diseases was of 9.5% in men and 18.9% in women [2] . Gallstones disease is the most common and costly of all digestive disease in the United States, resulting in 700 000 cholecystectomies and as many as 1 000 000 hospitalizations annually [3] . The frequency of hospital admission and operation for gallstones increased in Western countries since the 1950s [4] . In England the age-standardized hospital admission rate for cholelithiasis enhanced from 68.7 to 104.9 per 100 000 population between 1989/1990 and 1999/2000 and it increased progressively with age from 1.1 per 100 000 in the 0-14 year age group to 277.1 per 100 000 in the ≥ 85-year age group in 1999/2000 [5] . Guidelines for management of cholelithiasis are available for adults. Cholecystectomy is recommended for

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Section: Patients Observed At Medical Departmentsmentioning

confidence: 99%

Management of cholelithiasis in Italian children: A national multicenter study

Corte¹,

Falchetti²,

Nebbia³

et al. 2008

WJG

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“…12 Use of ursodeoxycholic acid also has been reported to cause the resolution of gallstones. 13 It is difficult to ascertain the cause of gallstone in our case, since none of the commonly reported maternal or neonatal risk factors were present. Though the mother had evidence of chronic hemolysis, she did not have any gallstone herself.…”

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confidence: 74%

Fetal cholelithiasis in a case of beta-thalassemia major

Basu

Verma

Kumar

2015

Clinical Epidemiology and Global Health

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“…8,11 Most resolve spontaneously in utero or within the first few months of birth. 1,9,11 Possible explanations include the passage of calculi into the gut, or the dilution of the cholesterol crystals once the infant begins to feed and hydrate. 5,7,8 However, a postnatal ultrasound scan is required to confirm their presence and exclude biliary tract obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…In the absence of jaundice or obstruction, the gallstone is managed conservatively with a view that it will resolve naturally, although medical treatment, if necessary, can be with ursodeoxycholic acid (UDCA), which dissolves gallstones. 1,6 There is some evidence of a link between fetal cholelithiasis and gender. Male fetuses may be more predisposed to developing gallstones than female fetuses, 9 and our search of the literature revealed only one or two examples of female neonates with gallstones.…”

Section: Discussionmentioning

confidence: 99%

Antenatal diagnosis of fetal cholelithiasis

Holloway

Edwards

2010

Ultrasound

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Fetal cholelithiasis is extremely rare and there are few reported cases in the literature. Most cases are thought to develop in late pregnancy and while some may be identified during a third trimester scan, others will remain undetected. Although cholelithiasis is not a life-threatening condition, other more serious pathologies must be excluded first. We describe an example of cholelithiasis in a male fetus in the third trimester. Ultrasound appearances, differential diagnoses and postnatal outcome are discussed.

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Fetal Gallstones

Abstract: The significance and natural history of fetal cholelithiasis is not yet well defined. We report two cases of echogenic foci detected prenatally by ultrasound. The gallstones resolved in both cases by 16 weeks following birth. Both infants were treated by ursodeoxycholic acid.

Cited by 20 publications

References 14 publications

Management of cholelithiasis in Italian children: A national multicenter study

Management of cholelithiasis in Italian children: A national multicenter study

Fetal cholelithiasis in a case of beta-thalassemia major

Antenatal diagnosis of fetal cholelithiasis

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