Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery

Lockwood, Charles J.; Senyei, Andrew E.; Dische, M. Renate; Casal, David; Shah, Kalpit N.; Thung, Swan N.; Jones, Lynn A.; Deligdisch, Liane; Garite, Thomas J.

doi:10.1097/00006254-199202000-00004

Cited by 36 publications

(62 citation statements)

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“…All studies except three [52][53][54] (which accounted for 0.28% of the 22 390 women in our review) used thresholds of 50 ng/ml to indicate an abnormal test result. 8 …”

Section: Data Synthesismentioning

confidence: 99%

“…Future research should focus on undertaking high quality primary studies of test accuracy to improve our ability to predict spontaneous preterm birth. Peaceman (1997) 65 Peaceman (1997) 65 Lockwood (1991) 8 Rizzo (1997) 92 Rizzo (1996) 91 Rizzo (1996) 91 Bartnicki (1996) 21 Iams (1995) 60 Malagrida (1995) 82 Calda (1995) 85 Lopez (2000) 59 Malak (1996) 63 Irion (1995) 88 Rozenberg (1997) 93 Hampl (1994) 54 Mansouri (1997) 98 Chuileannain (1998) 95 Giles (2000) 58 Malagrida (1995) 82 Langer (1997) 89 Goffeng (1997) LaShay (2000) 31 Benattar (1997) Inglis (1994) 79 Peaceman (1997) 65 Vetr (1996) 96 Grandi (1996) 48 Surbek (1997) 83 Roubille (1999) 84 Vercoustre (1996) 81 Vercoustre (1996) 81 Nageotte (1992) 70 Morrison (1993) 49 Overall (95% CI) …”

Section: Fig 13mentioning

confidence: 99%

“…7 The results may indicate the likelihood of spontaneous preterm birth. 8 In clinical use, however, factors such as contamination of the sample with maternal blood, 9 sampling within 24 hours after intercourse, 10 and pre-eclampsia 11 may reduce the accuracy of the test and give false positive results.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Accuracy of cervico-vaginal fetal fibronectin test in predicting the risk of spontaneous preterm birth—a systematic review

Honest

Bachmann²,

Kleijnen³

et al. 2003

Journal of Obstetrics and Gynaecology

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Objective To determine the accuracy with which a cervicovaginal fetal fibronectin test predicts spontaneous preterm birth in women with or without symptoms of preterm labour. Design Systematic quantitative review of studies of test accuracy. Data sources Medline, Embase, PASCAL, Biosis, Cochrane Library, Medion, National Research Register, SCISEARCH, conference papers, manual searching of bibliographies of known primary and review articles, and contact with experts and manufacturer. Study selection Two reviewers independently selected and extracted data on study characteristics, quality, and accuracy. Data extraction Accuracy data were used to form 2×2 contingency tables with spontaneous preterm birth before 34 and 37 weeks' gestation and birth within 7-10 days of testing (for symptomatic pregnant women) as reference standards. Data were pooled to produce summary receiver operating characteristic curves and summary likelihood ratios for positive and negative test results. Data synthesis 64 primary articles were identified, consisting of 28 studies in asymptomatic women and 40 in symptomatic women, with a total of 26 876 women. Among asymptomatic women the best summary likelihood ratio for positive results was 4.01 (95% confidence interval 2.93 to 5.49) for predicting birth before 34 weeks' gestation, with corresponding summary likelihood ratio for negative results of 0.78 (0.72 to 0.84). Among symptomatic women the best summary likelihood ratio for positive results was 5.42 (4.36 to 6.74) for predicting birth within 7-10 days of testing, with corresponding ratio for negative results of 0.25 (0.20 to 0.31). Conclusion Cervicovaginal fetal fibronectin test is most accurate in predicting spontaneous preterm birth within 7-10 days of testing among women with symptoms of threatened preterm birth before advanced cervical dilatation.

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“…All studies except three [52][53][54] (which accounted for 0.28% of the 22 390 women in our review) used thresholds of 50 ng/ml to indicate an abnormal test result. 8 …”

Section: Data Synthesismentioning

confidence: 99%

Section: Fig 13mentioning

confidence: 99%

See 1 more Smart Citation

Accuracy of cervico-vaginal fetal fibronectin test in predicting the risk of spontaneous preterm birth—a systematic review

Honest

Bachmann²,

Kleijnen³

et al. 2003

Journal of Obstetrics and Gynaecology

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“…It is obvious that the clinical usefulness of total plasma FN as a tumour marker is limited and, recently, interest has been focused on the expression of different fragments or isoforms of FN. FN fragments in urine have been studied as a marker for malignancy (Katayama et al, 1991), and different isoforms of FN, including EDAcFN and oncofetal FN, have been studied as markers for benign conditions, such as vascular injury and acute pulmonary injury, or as a predictor of pre-term delivery (Peters et al, 1988(Peters et al, , 1989Lockwood et al, 1991).…”

Section: Edacfn In Plasma Of Patients With Benign Diseasesmentioning

confidence: 99%

Cellular fibronectin concentration in the plasma of patients with malignant and benign diseases: a comparison with CA 19-9 and CEA

Haglund

Ylätupa²,

Mertaniemi³

et al. 1997

Br J Cancer

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Summary EDAcFN enzyme immunoassay (EIA) is a new tumour marker assay measuring the extra domain A-containing isoform of cellular fibronectin (cFN), a component mainly found in extracellular matrices. The concentration cFN was measured in plasma and serum from 468 patients with malignant and benign diseases. The concentrations of cFN were higher in plasma than in serum. Using receiver operating characteristic (ROC) curve analysis, determination from plasma was superior to serum at specificity levels higher than 78% and was chosen for further analysis. The highest frequencies of elevated cFN values were seen in patients with hepato-pancreato-biliary malignancies (50-67%). In pancreatic and bile duct cancers, cFN provided little further information to that obtained by CA 19-9. The greatest advantage over CA 19-9 and CEA was seen in patients with local colorectal cancer and in hepatocellular carcinomas. Four out of nine patients with Dukes' stage B colorectal cancer had an elevated cFn level, but only one had an abnormal CEA level. In hepatocellular carcinomas, cFN was also compared with alpha-fetoprotein. The sensitivity of cFN (72%) was superior to that of AFP (61%), and concomitant use of cFN and AFP raised the sensitivity to 83%. The highest frequencies of elevated values in patients with benign diseases were observed in those with severe liver disease (32%) and biliary (17%) and pancreatic (24%) diseases. A combination of cFN and CA showed the highest overall sensitivity of 47%, compared with 31% for cFN and 33% for CA 19-9. The corresponding specificities were 76% for cFN ± CA 19-9, 85% for cFN and 83% for CA 19-9. The accuracy of a combination of cFN and CA 19-9 or CEA (60% respectively) was higher than that of cFN (55%), CA 19-9 (55%) or CEA (45%) alone. In conclusion, the results of the new cFN test are encouraging and further studies on larger patient materials have been started.

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“…PEMR hâlâ pek çok açıdan bilinmezliğini korumaktadır. Şimdiye dek şüpheli EMR olgularına tanı koymak amaçlı amnion mayiinde birçok madde üzerinde çalışılmıştır (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) . Bunlardan bir tanesi de amnion mayiinde laktat konsantrasyonunun ölçümüdür (23) .…”

Section: Introductionunclassified

Relationship between Amniotic Fluid Lactate Concentration and Onset of Spontaneous Labour in Cases of Preterm Premature Rupture of Membranes

Telli¹,

Özdemir²,

Yıldırım³

et al. 2018

IKSST

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ÖZ Amaç: Preterm erken membran rüptürü (PEMR) olgularında amnion sıvısı laktat konsantrasyonunun, kendiliğinden doğum eylemi üzerine öngörüsü araştırılarak; böylesi olgularda maternal ve fetal yaklaşım standardı açısından bilgi sağlanması amaçlan-dı. Gereç ve 89±1,45 (%95 GA: 6,86) (duyarlılık %92,3; özgüllük %36,6; pozitif LR 1,46; negatif LR 0,21, duyarlılık %68,1; özgüllük %57,7; pozitif LR 1,61; negatif LR 0,55, sırasıyla), fakat eğrilerin altında kalan alanlar anlamlı değildi (AUC=0,56, %95 GA 0,67; p=0,380, AUC=0,59, %95 GA 0,70; p=0,196 sırasıyla days. The best cut-off value to predict the onset of spontaneous labour within 48 hours and 7 days was 7 mmol/l and 8.1 mmol/l (sensitivity 92.3%; specificity 36.6%; positive LR 1.46; negative LR 0.21 vs sensitivity 68.1%; specifivity 57.7%; positive LR 1.61; negative LR 0.55, respectively), but areas under curve were not statistically significant (AUC=0.56%, p=0.380, AUC=0.59, p=0.196 respectively). Conclusion

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Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery

Cited by 36 publications

References 0 publications

Accuracy of cervico-vaginal fetal fibronectin test in predicting the risk of spontaneous preterm birth—a systematic review

Accuracy of cervico-vaginal fetal fibronectin test in predicting the risk of spontaneous preterm birth—a systematic review

Cellular fibronectin concentration in the plasma of patients with malignant and benign diseases: a comparison with CA 19-9 and CEA

Relationship between Amniotic Fluid Lactate Concentration and Onset of Spontaneous Labour in Cases of Preterm Premature Rupture of Membranes

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