Fetal fibronectin as predictor of successful induction of mid‐trimester abortion

Abstract

A positive cervical fetal fibronectin test does not predict a successful medical termination of pregnancy in second trimester abortion. In this setting, the role of fetal cervical fibronectin in cervical ripening is, therefore, questionable.

The cervical mucus plug: Structured review of the literature

“…In addition to the previously mentioned inflammatory markers, other biologically active proteins detected in the CMP have been proposed as biomarker candidates in a variety of clinical settings: (1) the highly phosphorylated decidual isoform of insulin‐like growth factor‐binding protein‐1 (phosphorylated IGFBP‐1) for preterm birth (76–78); (2) fFN for intra‐amniotic inflammation (79) and cervical ripening (80), (81); (3) human chorionic gonadotropin (hCG) for preterm delivery (82) and early miscarriage (83); and (4) nitric oxide (NO) metabolites for cervical ripening (84). Moreover, the detection of fetal cells in the CMP by immunohistochemistry may imply that future prenatal diagnosis can be performed by lesser invasive procedures than amniocentesis (33–35).…”