Fetal facial sonographic markers for second trimester Down syndrome screening in a Thai population

Sooklim, Ratchadawan; Manotaya, Saknan

doi:10.1016/j.ijgo.2010.06.005

Cited by 14 publications

(11 citation statements)

References 9 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This difference could potentially be a result of the modified measurement protocol, introducing the frontal process of the maxilla as a necessary landmark for accurate caliper placement. Furthermore, several authors have reported FMFA measurements to be constant in the second trimester, supporting the utility of FMFA measurement as a secondary trisomy 21 marker beyond the first trimester [22][23][24] . The recent finding of reduced first trimester FMFA measurement in fetuses with spina bifida is another reason to consider training operators in this parameter [25] .…”

Section: Discussionmentioning

confidence: 81%

Frontomaxillary Facial Angle Measurement in Trisomy 21 and Euploid Fetuses: Two- and Three-Dimensional Assessment during Routine First Trimester Screening

et al. 2014

View full text Add to dashboard Cite

Objective: To assess 2D and 3D frontomaxillary facial angle (FMFA) measurements in euploid and trisomy 21 fetuses. Materials and Methods: Over a 2-year period, women with singleton pregnancies attending a private prenatal screening and diagnosis practice in Sydney, Australia, were invited to participate in this study where 2D images and 3D volumes of the fetal face were collected during routine first trimester screening. In pregnancies where trisomy 21 was confirmed, FMFA measurements were performed in 2D and 3D and compared with those from a euploid cohort. Results: Overall, 250 women carrying euploid and 22 women carrying trisomy 21 fetuses participated. Trisomy 21 fetuses had significantly larger FMFA measurements than euploid fetuses in both 2D and 3D assessments. 95% of 3D and 100% of 2D FMFA measurements for the trisomy 21 fetuses were above the mean FMFA measurement of the euploid fetuses. There was no relationship between increasing crown-rump length and FMFA measurement. Conclusion: 2D and 3D FMFA measurements in trisomy 21 fetuses are statistically greater (p < 0.001) than those in euploid fetuses. This supports FMFA as a possible additional marker for trisomy 21 for first trimester screening.

show abstract

Section: Discussionmentioning

confidence: 81%

Frontomaxillary Facial Angle Measurement in Trisomy 21 and Euploid Fetuses: Two- and Three-Dimensional Assessment during Routine First Trimester Screening

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Of the 137 remaining articles, 24 analyzing the usefulness of NB assessment in diagnosing Down syndrome were chosen. Finally, 21 studies were selected for the quantitative synthesis of this systematic review. Of these, 13 analyzed NB absence as an ultrasound marker, 15 measured NB hypoplasia or absence and eight assessed the BPD/NBL ratio (Table S1).…”

Section: Resultsmentioning

confidence: 99%

“…The quality of 15 of the studies was acceptable (medium or high) (Table S2), according to the criteria outlined in the Osteba Critical Reading guidelines. Interobserver agreement was assessed in only three of these studies.…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta‐analysis of performance of second‐trimester nasal bone assessment in detection of fetuses with Down syndrome

Moreno-Cid

Rubio-Lorente

Rodríguez

et al. 2014

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

show abstract

“…Another study in a Thai population reported that the overall mean frontomaxillary facial angle was 83.5° ± 4.5° between 16 and 20 weeks' gestation. 34 In Korean fetuses at 11 weeks to 13 weeks 6 days, it was reported that the overall mean frontomaxillary facial angle was 88.6° ± 9.7°. 30 Our study showed that the mean frontomaxillary facial angle was 87.1° ± 7.9° between 14 and 25 weeks, and the overall mean frontomaxillary facial angle was 86.0° ± 7.6° between 14 and 39 weeks without a significant association between the frontomaxillary facial angle and the gestational week.…”

Section: Discussionmentioning

confidence: 99%

Craniofacial Inclination at 14 to 39 Weeks' Gestation in Normal Korean Fetuses

Lee

Choi

et al. 2012

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Objectives The purpose of this study was to evaluate a normal range for prenatal craniofacial inclination using images of fetal profiles at 14 to 39 weeks' gestation in normal Korean fetuses. Methods We conducted a cross‐sectional study of 308 normal fetuses at 14 to 39 weeks' gestation. After the exclusion of images with inadequate quality, the sagittal plane of the sonographic fetal facial profile from 250 normal fetuses was evaluated. The frontomaxillary facial, frontonasal, maxilla‐nasion‐mandibular, and mandibulomaxillary facial angles were measured and are presented according to gestational age. Results The overall mean frontomaxillary facial angle ± SD was 86.0° ± 7.6° between 14 weeks 6 days' and 39 weeks 2 days' gestation without a significant association between the frontomaxillary facial angle and gestational week. The overall mean frontonasal, maxilla‐nasion‐mandibular, and mandibulomaxillary facial angles were 125.8° ± 7.2°, 4.7° ± 3.3°, and 83.2° ± 8.5° between 14 weeks and 39 weeks 6 days. There was a significant linear correlation between gestational age and the frontonasal angle (r = −0.1534; P = .0187; y = −0.188 × gestational age + 130.7), maxilla‐nasion‐mandibular angle (r = −0.2773; P < .0001; y = −0.160 × gestational age + 9.0), and mandibulo‐maxillary facial angle (r = −0.2861; P < .0001; y = −0.432 × gestational age + 94.6). Conclusions We provide preliminary normative data for fetal facial angles related to craniofacial inclination across gestational ages in normal Korean fetuses. These data may be of help not only for the understanding of normal facial growth in utero but also for diagnosis of abnormal fetal facial dimensions.

show abstract

Fetal facial sonographic markers for second trimester Down syndrome screening in a Thai population

Abstract: The combination of FMF angle and BPD:NBL ratio has a high sensitivity and specificity for screening for DS in the second trimester in a high-risk Thai population.

Cited by 14 publications

References 9 publications

Frontomaxillary Facial Angle Measurement in Trisomy 21 and Euploid Fetuses: Two- and Three-Dimensional Assessment during Routine First Trimester Screening

Frontomaxillary Facial Angle Measurement in Trisomy 21 and Euploid Fetuses: Two- and Three-Dimensional Assessment during Routine First Trimester Screening

Systematic review and meta‐analysis of performance of second‐trimester nasal bone assessment in detection of fetuses with Down syndrome

Craniofacial Inclination at 14 to 39 Weeks' Gestation in Normal Korean Fetuses

Contact Info

Product

Resources

About