Fetal exposure to dietary carcinogens and risk of childhood cancer: what the NewGeneris project tells us: Table 1

Kleinjans, J. C. S.; Botsivali, Maria; Kogevinas, Manolis; Merlo, Domenico Franco

doi:10.1136/bmj.h4501

Cited by 16 publications

(7 citation statements)

References 26 publications

(25 reference statements)

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“…Interestingly, O(6)-methylguanine detected in human cord blood in mothers highly exposed to such products implicates nitrosodimethylamine exposure of the fetus and toxicity from dietary sources of these compounds (63). Maternal dietary exposure to N-nitroso compounds or to their precursors during pregnancy has also been associated with preterm birth (64) and risk of childhood cancer (65). Childhood cancer is most probably the combinatorial result of both genetic and environmental factors, and these networks between fetal exposure to environmental carcinogens such as nitrosamines from tobacco and/or dietary sources, preterm birth, and increased risk of childhood cancer may be an underlying cause for at least a subset of HBs.…”

Section: Discussionmentioning

confidence: 99%

Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients

et al. 2020

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“…Interestingly, O(6)-methylguanine detected in human cord blood in mothers highly exposed to such products implicates Nitrosodimethylamine exposure of the fetus and toxicity from dietary sources of these compounds [56]. Maternal dietary exposure to N-nitroso compounds or to their precursors during pregnancy has also been associated with preterm birth [57] and risk of childhood cancer [58]. Childhood cancer is most probably the combinatorial result of both genetic and environmental factors, and these networks between fetal exposure to environmental carcinogens such as nitrosamines from tobacco and/or dietary sources, preterm birth, and increased risk of childhood cancer may be an underlying cause for at least a subset of HBs.…”

Section: Discussionmentioning

confidence: 99%

Mutational burden of hepatoblastomas: a role for the CX3CL1/CX3CR1 chemokine signaling pathway

Costa

et al. 2019

Preprint

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Background: Hepatoblastoma is an embryonal liver tumor supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. CTNNB1 is the only recurrently mutated gene, and this relative paucity of somatic mutations poses a challenge to risk stratification and development of targeted therapies. Methods: In this study, we investigated by exome sequencing the burden of somatic mutations in a cohort of 10 hepatoblastomas, including a congenital case. Results: Our data disclosed a low mutational background with only three recurrently mutated genes: CTNNB1 and two novel candidates, CX3CL1 and CEP164. The major finding was a recurrent mutation (A235G) identified in two hepatoblastomas at the CX3CL1 gene; evaluation of RNA and protein expression revealed up-regulation of CX3CL1 in tumors. The analysis was replicated in two independents cohorts, substantiating that an activation of the CX3CL1/CX3CR1 pathway occurs in hepatoblastomas, with a predominance of these proteins in the cytoplasm of tumor cells. These proteins were not detected in the infiltrated lymphocytes of inflammatory regions of the tumors, in which they should be expressed in normal conditions, whereas necrotic regions exhibited negative tumor cells, but strongly positive infiltrated lymphocytes. Our data suggested that CX3CL1/CX3CR1 upregulation may be a common feature of hepatoblastomas, potentially related to chemotherapy response and progression. In addition, three mutational signatures were identified in hepatoblastomas, two of them with predominance of either the COSMIC signatures 1 and 6, found in all cancer types, or the COSMIC signature 29, related only with tobacco chewing habit; a third novel mutational signature presented an unspecific pattern with an increase of C>A mutations. Conclusions: Overall, we present here evidence that CX3CL1/CX3CR1 chemokine signaling pathway is likely involved with hepatoblastoma tumorigenesis or progression, besides reporting a novel mutational signature specific to a hepatoblastoma subset.

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“…Industry also has a crucial role in the quality of raw materials used in the preparation of consumer products. This is essential for the presence or absence of hazardous chemicals [ 5 ]. This issue is beyond the awareness of consumers including pregnant women and advisers such as health care professionals.…”

Section: Implications Of the Hypothesismentioning

confidence: 99%

“…Early exposures to EDCs can have huge impact on development and on the risk of diseases such as adult reproductive failure, cancer, obesity, diabetes and metabolic syndrome, and neurodevelopmental disorders among others [ 11 ]. Fetal exposure to dietary carcinogens seems to induce molecular events that indicate increased cancer risks together with other adverse health effects such as reduced birth weight and head circumference [ 5 ]. Childhood cancer, in particular leukemia among boys, can be causally related to the maternal dietary intake of carcinogenic substances during pregnancy [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Fetal exposure to dietary carcinogens seems to induce molecular events that indicate increased cancer risks together with other adverse health effects such as reduced birth weight and head circumference [ 5 ]. Childhood cancer, in particular leukemia among boys, can be causally related to the maternal dietary intake of carcinogenic substances during pregnancy [ 5 ]. Fetal exposure to mutagens such as polycyclic aromatic hydrocarbons also increases the risk of cancer and neurodevelopmental disorders [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors

et al. 2018

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BackgroundThe regulatory management of chemicals and toxicants in the EU addresses hundreds of different chemicals and health hazards individually, one by one. An issue is that, so far, the possible interactions among chemicals or hazards are not considered as such. Another issue is the anticipated delay of several decades before effective protection of public health by regulatory decisions due to a time consuming process. Prenatal and early postnatal life is highly vulnerable to environmental health hazards with lifelong consequences, and a priority period for reduction of exposure. There are some initiatives regarding recommendations for pregnant women aiming at protection against one or another category of health hazard, however not validated by intervention studies.HypothesisHere, we aim at strengthening the management of exposure to individual health hazards during pregnancy and lactation, with protective measures in a global strategy of Environmental Hygiene. We hypothesize that such a strategy could reduce both the individual effects of harmful agents in complex mixtures and the possible interactions among them. A panel of experts should develop and endorse implementable measures towards a protective behavior. Their application is meant to be preferably as a package of measures in order to maximize protection and minimize interactions in causing adverse effects. Testing our hypothesis requires biomonitoring studies and longitudinal evaluation of health endpoints in the offspring. Favorable effects would legitimate further action towards equal opportunity access to improved environmental health.ConclusionEnvironmental Hygiene is proposed as a global strategy aiming at effective protection of pregnant women, unborn children and infants against lifelong consequences of exposure to combinations of adverse lifestyle factors.Electronic supplementary materialThe online version of this article (10.1186/s12940-018-0385-y) contains supplementary material, which is available to authorized users.

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Fetal exposure to dietary carcinogens and risk of childhood cancer: what the NewGeneris project tells us: Table 1

Abstract: Jos Kleinjans and colleagues summarise the evidence from a European study using biomarkers to assess how maternal diet affects the child

Cited by 16 publications

References 26 publications

Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients

Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients

Mutational burden of hepatoblastomas: a role for the CX3CL1/CX3CR1 chemokine signaling pathway

Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors

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