Fetal echocardiography for early detection of congenital heart diseases

Narasimhan, Chitra; Vijayalakshmi, IB

doi:10.1007/s12574-016-0308-2

Cited by 23 publications

(20 citation statements)

References 13 publications

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“…The average gestational week in the first evaluation was 24±4.2 in our study. In other studies, fetal echocardiography was performed in similar gestational weeks (7,8). The most common reason for admission to our clinic was the suspicion of CHD in accordance with the literature (7,8).…”

Section: Discussionsupporting

confidence: 60%

Fetal Echocardiography Characteristics in a Tertiary Center

Erolu¹

2020

Erciyes Med J

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Objective: Fetal echocardiography is an important and growing diagnostic tool for early detection of congenital heart diseases and rhythm problems. In this study, we evaluated retrospectively indications and prenatal and postnatal diagnoses for fetal echocardiography. Materials and Methods: Prenatal and postnatal echocardiographic diagnoses of the newborns and data of pregnant women who were referred to the Pediatric Cardiology Clinic of Ümraniye Training and Research Hospital between October 2018 and October 2019 and newborns were obtained from medical recordings. Results: In this study, 138 patients were included. Eighty-one (58%) indication was suspected congenital heart disease, twenty-four indications (13%) was screening test positivity, 10 hyperechogenic focus, two advanced age pregnancy, six diabetes mellitus. Two were hydrops fetalis (immune/nonimmune), five dysrhythmias, one fetal anomaly. Hereditary causes were congenital heart disease in seven previous pregnancies. Sixty-eight patients with normal fetal echocardiography were normal in the postnatal period. Diagnosis of cyanotic congenital heart diseases was 24.2% of all patients, and 47.1% were acyanotic congenital heart disease in our study population. Four of the patients had arcus aorta anomalies. One patient had sustained supraventricular tachycardia with hydrops fetalis resolved with sotalol and digoxin treatment. One patient had neonatal thyrotoxicosis because of maternal graves disease Conclusion: Fetal echocardiography is a useful and noninvasive method for early diagnosis and treatment, especially in rhythm problems. Also, diagnosis of congenital heart diseases antenatally is useful for planning the management of the disease.

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Section: Discussionsupporting

confidence: 60%

Fetal Echocardiography Characteristics in a Tertiary Center

Erolu¹

2020

Erciyes Med J

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“…In this study, the HLHS forms 9.4% of CHDs. Chitra et al reported this rate as 15% [9]. This difference may result from that our centre does not have a pediatric cardiovascular unit which could have great importance for newborn survival after birth and this condition might affect parents' preference for choosing the centre for delivery.…”

Section: Discussionmentioning

confidence: 89%

Pregnancy follow-up and outcomes of patients diagnosed with fetal hypoplastic left heart syndrome

Çelik

Yılmaz

Obut

et al. 2020

Aegean J Obstet Gynecol

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Objective: The study aimed to evaluate the follow-up and outcomes of patients diagnosed with fetal hypoplastic left heart syndrome in the prenatal period. Materials: Between January 2017 and June 2019 the data of 36 patients diagnosed with fetal hypoplastic left heart syndrome (HLHS) in Etlik Zübeyde Hanım Woman’s Health Care Training and Research Hospital (EZH) were evaluated retrospectively. All patients who suspected for any fetal or cardiac anomaly were evaluated in detail ultrasound by two senior perinatologists and a pediatric cardiologist fort a detailed cardiac evaluation. The demographic characteristics, pregnancy follow-up and maternal and fetal outcomes of patients were evaluated. Results: During the study period fetal echocardiography was performed for 10.377 patients. A totally 382 (3.7%) fetuses were diagnosed with congenital heart diseases and 36 (9.4%) of these fetuses were diagnosed with hypoplastic left heart syndrome. Additional extracardiac anomalies were detected in 13 (36.1%) fetuses. Concomitant fetal cardiac anomalies were detected in 15 patients and ventricular septal defect (n: 11) and double outlet right ventricle (n:8) were the most common concomitant cardiac anomalies. Eight pregnancies with fetal HLHS were terminated. The data of 10 patient’s newborns were obtained and none of them lived up to a year. Conclusion: The study revealed that the majority of patients with fetal HLHS are in low-risk population thus the routine fetal cardiac evaluation is of great importance. The prognosis and outcome of the pregnancy diagnosed with fetal HLHS are poor. The option of termination of the pregnancy should be considered.

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“…This is not in agreement with previous studies showing a correlation between fetal EIF and congenital heart diseases. 10 , 21 , 22 Currently, karyotyping, FISH, multiplex ligation-dependent probe amplification (MLPA) and CMA are major tools used to detect the chromosomal abnormality in fetuses with ultrasound soft markers. 23 , 24 Chromosomal karyotype analysis is limited by the success rate of culture and the resolution, while CMA is effective to detect abnormality of chromosomal fragments with >1 kb in size and microduplication and microdeletion syndromes.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Chromosomal Microarray Analysis for Prenatal Diagnosis of Fetal Echogenic Intracardiac Focus: A Single-Center Experience

Huang¹,

Cai²,

Liu³

et al. 2021

IJGM

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Background: Echogenic intracardiac focus (EIF) is a common ultrasound finding during pregnancy. However, the correlation between fetal EIF and cardiac abnormality remains in dispute until now. The study aimed to examine the association of fetal EIF with chromosomal abnormality by means of chromosomal microarray analysis (CMA). Materials and Methods: A total of 192 pregnant women with fetal EIF undergoing amniocentesis or umbilical cord blood puncture were recruited and assigned into groups A (8 cases with isolated EIF alone), B (75 cases with EIF and other cardiac malformations) and C (109 cases with EIF and extracardiac malformations). All fetuses underwent karyotyping analysis and CMA simultaneously. The detection of chromosomal abnormality and copy number variations (CNVs) were compared. Results: Chromosomal karyotyping identified 5 fetuses with chromosomal abnormality, including 3 cases with trisomy 21, one fetus with Turner's syndrome, and one fetus with chromosome 8 mosaicism, while CMA detected 6 additional fetuses with CNVs, including 2 fetuses with pathogenic CNVs and 4 fetuses with variants of uncertain significance (VOUS). There was no significant difference among groups A (0), B (5.33%) and C (6.42%) in terms of the prevalence of chromosomal abnormality (P> 0.05). Among the 4 fetuses with VOUS, pregnancy continued in 2 fetuses, and pregnancy was terminated in other 2 fetuses. Conclusion: An isolated EIF may not correlate with chromosomal abnormality. However, CMA is recommended in fetuses with CMA complicated by other abnormal cardiac ultrasound findings, which facilitates the prediction of fetal outcomes during the genetic counseling and precision assessment of prognosis.

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Fetal echocardiography for early detection of congenital heart diseases

Cited by 23 publications

References 13 publications

Fetal Echocardiography Characteristics in a Tertiary Center

Fetal Echocardiography Characteristics in a Tertiary Center

Pregnancy follow-up and outcomes of patients diagnosed with fetal hypoplastic left heart syndrome

Effectiveness of Chromosomal Microarray Analysis for Prenatal Diagnosis of Fetal Echogenic Intracardiac Focus: A Single-Center Experience

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