Fetal Diagnosis of Interrupted Aortic Arch

Vogel, M; Vernon, Margaret M.; McElhinney, Doff B.; Brown, David W.; Colan, Steven D.; Tworetzky, Wayne

doi:10.1016/j.amjcard.2009.10.053

Cited by 27 publications

(33 citation statements)

References 18 publications

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“…Diagnosis of IAA in the fetus is difficult, as on 2-DE the 4-chamber view may be mistaken for normal since all 4 chambers, the valves and crossing of the outflow tracts are present. In IAA there is almost always a large VSD resulting in equally sized ventricles [19] , which was also observed in our series of patients with IAA without further complex cardiac anomalies ( fig. 1 ).…”

Section: Discussionsupporting

confidence: 59%

“…All 8 prenatally diagnosed patients were detected after 2005. This compares to the data of Vogel et al [19] , who reported an in utero diagnosis in only 24% of cases in a cohort of 82 individuals with IAA over a period of 21 years. Vogel et al [19] found an increase in frequency of the prenatal diagnosis of IAA from initially 11 to 43% in most recent years.…”

Section: Discussionmentioning

confidence: 46%

“…This compares to the data of Vogel et al [19] , who reported an in utero diagnosis in only 24% of cases in a cohort of 82 individuals with IAA over a period of 21 years. Vogel et al [19] found an increase in frequency of the prenatal diagnosis of IAA from initially 11 to 43% in most recent years. The increasing in utero detection of IAA may be related to several factors; the advent of high-frequency transducers, improvements in imaging processing, introduction of fetal echocardiography into the prenatal ultrasound examination and increasing awareness of sonographers.…”

Section: Discussionmentioning

confidence: 46%

“…Of the 28 neonates, 15 were male and 13 were female. The median gestational age at referral was 27 weeks (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Postnatal echocardiography confirmed IAA in all 8 neonates with prenatal diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…Although variable discrepancy in ventricular or great artery size may be seen, the diagnosis is confirmed by transverse and longitudinal views of the upper mediastinum, including the 3-vessel view demonstrating the pathology at the level of the aortic arch. Two recent studies have evaluated the fetal diagnosis of IAA, assessing the potential diagnostic value of 4-DE and the finding of a low aortopulmonary diameter ratio as an indicaton of IAA [18,19] .…”

Section: Introductionmentioning

confidence: 99%

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Fetal and Neonatal Diagnosis of Interrupted Aortic Arch: Associations and Outcomes

et al. 2011

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Objective: Interrupted aortic arch (IAA) is a rare but serious anomaly. Prenatal diagnosis is challenging and published data are limited. The aim of the study was to review the data of fetuses and neonates diagnosed with IAA during a 16-year period at Children’s Hospital Giessen. Methods: Retrospective ascertainment of 8 fetuses and 20 neonates with a confirmed diagnosis of IAA from 1994 to 2010 by reviewing the hospital database of the cardiovascular program of the prenatal and pediatric cardiology clinics at the University Hospital Giessen. Results: Eighteen cases with IAA type B and 10 cases with IAA type A were found. After 2005, prenatal diagnosis was achieved in 8 cases and postnatal imaging confirmed IAA in all 8 neonates. Twenty-nine percent of individuals had a chromosomal anomaly, with microdeletion 22q11.2 being the most common abnormality (n = 6, 21%). In 46% (13/28) other complex cardiac anomalies were present. Mortality after surgery was 18%. Long-term morbidity and mortality was due to neurological impairment in the presence of microdeletion 22q11.2 and the need of surgical or catheter re-intervention. Conclusion: Despite the difficulties and challenges in diagnosis, the prenatal detection rate of IAA is increasing. Associated complex cardiac and chromosomal abnormalities influence the outcome of patients with IAA and are important issues of parental counseling.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 46%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fetal and Neonatal Diagnosis of Interrupted Aortic Arch: Associations and Outcomes

et al. 2011

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Interrupted Aortic Arch

Nath

Jonas

2023

Pediatric Cardiac Surgery

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Usefulness of three vessel‐trachea view and parasagittal plan for prenatal diagnosis of interrupted aortic arch

Monteiro,

Cunha,

Sá

et al. 2023

Birth Defects Research

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BackgroundInterrupted aortic arch (IAA) is a rare congenital heart disease characterized by loss of continuity between the ascending and the descending aorta. Prenatal diagnosis of IAA by echocardiography is challenging but nonetheless can be accomplished via a systematization of cardiac fetal evaluation.Case PresentationWe report a case of fetal IAA type A prenatally diagnosed through two‐dimensional echocardiography using both a three vessel‐trachea view and a sagittal view.ConclusionPrenatal counseling regarding the diagnosis and prognosis about this anomaly is still challenging nowadays due to associated anomalies/chromosomal abnormalities who may impact the prognosis. Fetal autopsy in all cases of pregnancy termination after abnormal ultrasound findings is important in order to make a full diagnosis and characterize the anomaly.

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Fetal Diagnosis of Interrupted Aortic Arch

Cited by 27 publications

References 18 publications

Fetal and Neonatal Diagnosis of Interrupted Aortic Arch: Associations and Outcomes

Fetal and Neonatal Diagnosis of Interrupted Aortic Arch: Associations and Outcomes

Interrupted Aortic Arch

Usefulness of three vessel‐trachea view and parasagittal plan for prenatal diagnosis of interrupted aortic arch

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