Fetal death from chlamydial infection across intact amniotic membranes

Thorp, John M.; Katz, Vern L.; Fowler, Larry J.; Kurtzman, James; Bowes, Watson A.

doi:10.1016/0002-9378(89)90675-3

Cited by 46 publications

(12 citation statements)

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“…Such an interesting feature can be interpreted to represent an adaptation of the microbial community and the host to maximize reproductive fitness. We propose that the enhanced stability confers greater resilience and has a protective role against ascending infection of the genital tract, which is risk factor for preterm delivery [244-246] and other conditions such as a sonographic short cervix [247-249], cervical insufficiency [250-254], preterm labor in twin gestations [255-257], vaginal bleeding in the third trimester [258], placenta previa [259,260], or some cases of fetal death [261-265]. The mechanisms by which bacterial community stability promotes health in the vaginal niche remain to be determined.…”

Section: Discussionmentioning

confidence: 99%

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

et al. 2014

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BackgroundThis study was undertaken to characterize the vaginal microbiota throughout normal human pregnancy using sequence-based techniques. We compared the vaginal microbial composition of non-pregnant patients with a group of pregnant women who delivered at term.ResultsA retrospective case–control longitudinal study was designed and included non-pregnant women (n = 32) and pregnant women who delivered at term (38 to 42 weeks) without complications (n = 22). Serial samples of vaginal fluid were collected from both non-pregnant and pregnant patients. A 16S rRNA gene sequence-based survey was conducted using pyrosequencing to characterize the structure and stability of the vaginal microbiota. Linear mixed effects models and generalized estimating equations were used to identify the phylotypes whose relative abundance was different between the two study groups. The vaginal microbiota of normal pregnant women was different from that of non-pregnant women (higher abundance of Lactobacillus vaginalis, L. crispatus, L. gasseri and L. jensenii and lower abundance of 22 other phylotypes in pregnant women). Bacterial community state type (CST) IV-B or CST IV-A characterized by high relative abundance of species of genus Atopobium as well as the presence of Prevotella, Sneathia, Gardnerella, Ruminococcaceae, Parvimonas, Mobiluncus and other taxa previously shown to be associated with bacterial vaginosis were less frequent in normal pregnancy. The stability of the vaginal microbiota of pregnant women was higher than that of non-pregnant women; however, during normal pregnancy, bacterial communities shift almost exclusively from one CST dominated by Lactobacillus spp. to another CST dominated by Lactobacillus spp.ConclusionWe report the first longitudinal study of the vaginal microbiota in normal pregnancy. Differences in the composition and stability of the microbial community between pregnant and non-pregnant women were observed. Lactobacillus spp. were the predominant members of the microbial community in normal pregnancy. These results can serve as the basis to study the relationship between the vaginal microbiome and adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

et al. 2014

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“…Previously published reports describing C. trachomatis infection among infants born by cesarean section (19,20), and a case of fetal death (21) as well as a case with intrauterine pneumonia (22) and other studies have suggested the possibility of intrauterine infection (23)(24)(25). Furthermore, one of our earlier reports showing the presence of C. trachomatis in placental sections of a mother with stillbirth strengthens the role of C. trachomatis as an intrauterine threat to the fetus (12,24).…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis infection in mothers with preterm delivery and in their newborn infants^Note

Gencay¹,

Koskiniemi

Fellman

et al. 2001

APMIS

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We studied Chlamydia trachomatis infection in mothers with preterm delivery and intrauterine transmission of the infection to their offspring. Forty-one mothers with preterm labour and their newborn infants (n=50) were studied for the presence of C. trachomatis infection using microimmunofluorescence test for detection of serum antibodies against C trachomatis and polymerase chain reaction for detection of C. trachomatis-specific DNA in mucosal swabs. Antibodies to C trachomatis were found in serum of 12 mothers (29%). Five of fourteen mothers had C. trachomatis DNA in cervical specimens. Eighteen neonates were born to the 14 mothers with positive serology and/or C. trachomatis DNA. C. trachomatis DNA was detected in specimens from 10 of the 18 neonates (55.5%). Three of the available cord blood samples contained C trachomatis IgM antibodies. Our results strongly suggest that mothers and their preterm babies may benefit from screening for active C. trachomatis infection.

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“…39,40 A case of congenital pneumonia caused by C. trachomatis suggests that this micro-organism may be capable of causing ascending intra-amniotic infection. 39 The uncertainty about the role of C. trachomatis in the aetiology of microbial invasion and intrauterine infection may be related to difficulties in isolating the micro-organisms from amniotic fluid with standard culture techniques. 40 The use of polymerase chain reaction (PCR) to detect specific sequences for this micro-organism should help resolve this question.…”

Section: Microbiology Of Intrauterine Infectionmentioning

confidence: 99%

The role of infection in preterm labour and delivery

Romero

Gómez

Chaiworapongsa

et al. 2001

Paediatric Perinatal Epid

324

217

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Fetal death from chlamydial infection across intact amniotic membranes

Cited by 46 publications

References 3 publications

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

Chlamydia trachomatis infection in mothers with preterm delivery and in their newborn infants^Note

The role of infection in preterm labour and delivery

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Fetal death from chlamydial infection across intact amniotic membranes

Cited by 46 publications

References 3 publications

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

Chlamydia trachomatis infection in mothers with preterm delivery and in their newborn infantsNote

The role of infection in preterm labour and delivery

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Chlamydia trachomatis infection in mothers with preterm delivery and in their newborn infants^Note