Fetal cystic hygroma: the importance of natural history

Noia, G.; Pellegrino, Marcella; Masini, Lucia; Visconti, Daniela; Manzoni, Carlo; Chiaradia, Giacomina; Caruso, Alessandro

doi:10.1016/j.ejogrb.2013.07.043

Cited by 33 publications

(26 citation statements)

References 25 publications

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“…It has been previously reported that intrauterine regression of the cystic hygroma may be associated with more favorable outcomes. 16 Additionally Müller described that the disappearance of an enlarged nuchal translucency before 14 weeks occurs in about 20% of affected fetuses and is associated with lower rates of aneuploidy. 17 In our study, we did not routinely evaluate for resolution, as the majority of patients underwent invasive testing upon initial detection of the cystic hygroma.…”

Section: Discussionmentioning

confidence: 99%

First trimester cystic hygroma: does early detection matter?

Scholl

Chasen

2016

Prenat Diagn

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Section: Discussionmentioning

confidence: 99%

First trimester cystic hygroma: does early detection matter?

Scholl

Chasen

2016

Prenat Diagn

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“…13 Although the previous lack of stratification by anatomic location makes direct comparison of our results challenging, the overall prevalence of chromosomal abnormalities in our sample appears similar to previous reports. 14 …”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of a Simplified Anatomically Based Nomenclature for Fetal Nuchal Lymphatic Anomalies

Longstreet

Balakrishnan

Saltzman

et al. 2014

Otolaryngol.--head neck surg.

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Objective To propose an anatomic classification for fetal nuchal lymphatic anomalies that will be clinically useful and to evaluate the classification’s value in predicting chromosomal abnormalities, pregnancy outcomes, other associated fetal anomalies, and spontaneous resolution of these lesions. Study Design Retrospective cohort study. Setting Tertiary academic hospital and affiliated tertiary children’s hospital. Subjects and Methods Mother-baby pairs diagnosed with fetal nuchal lymphatic anomalies in a prenatal ultrasound database. Anomalies were classified as nuchal thickening, dorsal lymphatic malformation, or ventral lymphatic malformation. Pregnancy outcomes, prevalence of chromosomal and anatomic abnormalities, and rates of spontaneous lesion resolution were determined for each group. Results The study included 189 patients: 58 with nuchal thickening, 120 with dorsal lymphatic malformation, and 11 with ventral lymphatic malformation. In fetuses for whom chromosomal analysis was available, chromosomal abnormalities were strongly associated with dorsal lymphatic malformations (83%), less associated with nuchal thickening (29%), and not associated with ventral lymphatic malformations. Dorsal lymphatic malformation predicted high rates of elective (43%) and spontaneous (20%) termination of pregnancy and showed the strongest association with cardiac, renal, and skeletal anomalies. Nuchal thickening was more likely to resolve in utero than dorsal lymphatic malformations, while no ventral lymphatic malformation resolved spontaneously. Conclusions Fetal nuchal anomalies demonstrate significant and clinically important prognostic differences depending on their anatomic location. The simple classification system proposed here therefore provides useful information to clinicians involved in the pre- and postnatal management of children with these anomalies.

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“…Spontaneous abortion occurred in 54 of these and 31 delivered. Good prognosis was observed in 21 cystic hygromas (9).Termination should not be offered in fetuses with normal karyotype before searching for any other fetal anomalies. Counselling about inconclusive prognosis should be given when karyotype is normal and no other anomaly is found.…”

Section: Women On the Other Side Of War And Poverty: Its Effect On Thmentioning

confidence: 95%