Fetal cardiac tumor: echocardiography, clinical outcome and genetic analysis in 53 cases

Chen, J.; Wang, J.; Sun, Hairui; Gu, Xiaoyan; Hao, Xiaoyan; Fu, Yuping; Zhang, Y.; Liu, X.; Zhang, Huaguo; Lv, Han; He, Yihua

doi:10.1002/uog.19108

Cited by 48 publications

(50 citation statements)

References 27 publications

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“…Prognosis of fetal lymphatic malformation has been related to lesion size, cystic and solid components, and presence of septations. 20,26,[28][29][30][31] In the 13 cases presented, we found no association whatsoever between location, lesion size or classification 20…”

Section: Discussionmentioning

confidence: 57%

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high‐risk fetal tumors: A retrospective single‐center cohort study over 20 years

Ulm

Muin

Scharrer

et al. 2020

Acta Obstet Gynecol Scand

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Section: Discussionmentioning

confidence: 57%

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high‐risk fetal tumors: A retrospective single‐center cohort study over 20 years

Ulm

Muin

Scharrer

et al. 2020

Acta Obstet Gynecol Scand

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“…Out ow tract obstruction is not rare occurred in approximately 10% of our subjects. But severe hemodynamics disorders were scattered partly because multiple CRs, which accounted for 70% in this study, tended to be smaller [9] and chamber located [10] . Although 83.7% of tumors increased by the stimulation of maternal estrogen prenatally [11] , the increment reduced after the 32nd week [12] .…”

Section: The In Uence Of Tumor On Perinatal Outcomementioning

confidence: 55%

A Multidisciplinary Approach in Prenatal Diagnosis of TSC With Cardiac Rhabdomyoma as the Initial Symptom

Ding

Huang

et al. 2020

Preprint

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The long-term prognosis of fetus with cardiac rhabdomyoma (CR) depends on the correlation with tuberous sclerosis complex(TSC). Recent years, numerous variations of uncertain significance (VUS) of TSC genes produced by high-throughput sequencing makes counseling challenging, studies until now tend to sidestep the tricky topics. Here, we integrated detailed parental phenotype, echocardiography, neuro MRI and genetic information to conduct a comprehensive evaluation for 61 CR fetuses. As a result, multiple CRs and cerebral lesions appeared in 90% and 80% respectively in fetuses with pathogenic(P)/likely pathogenic(LP) TSC1/TSC2 variation. 85.7% of the live-born with P/LP presented TSC-associated signs. 85.7% VUS without nervous findings had good prognosis. Genetic evidence and cerebral MRI findings are the most sensitive index to assess long-term prognosis, which complement and confirm each other for a TSC diagnosis. 68.9% fetuses with CR could benefit from this multidisciplinary approach, which turned to be potentially clinically actionable with precise clinical/genetic diagnosis or had a foreseeable outcome. Our practice provides a practical and feasible solution for perinatal management and prognostic guidance for fetuses with CR.

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“…Because in the current literature it is easier to find information about termination of pregnancies [36] than about natural follow-up, we believe that the presented data from our centre should be known to the medical society.…”

Section: Discussionmentioning

confidence: 99%

“…They can cause haemodynamic changes, which may threaten fetal well-being or can even be fatal, unless monitored [8,9]. Echocardiography remains the main tool for monitoring and early clinical diagnosis [10][11][12][13], although histopathology and genetics are still significant in the diagnosis and treatment of benign cardiac tumours [14,15].…”

Section: Discussionmentioning

confidence: 99%

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Fetal cardiac tumours in a referral prenatal cardiology centre – series of 37 cases with neonatal follow-up

Strzelecka¹,

Sylwestrzak²,

Krekora³

et al. 2019

pcard

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Introduction: Fetal cardiac tumours are relatively rare findings. The aim of this research was to present the natural course in a series of 37 fetuses with cardiac tumours, who had fetal echocardiography performed and the pregnancies had been continued until term. Material and methods: This was a retrospective analysis of 37 cases with prenatally detected heart tumour. The study group was divided into multiple-and single-tumour subgroups and into survivors versus non-survivors. The number of survivors in subgroups and the incidence of prognostic factors were compared by c 2 test. The presence of additional cardiac anomalies, the way of delivery and neonatal follow-up was analysed. The literature (Pub Med) was reviewed. Results: There was no statistical difference between the number of survivors in groups of single versus multiple tumours (p > 0.05). In group of non-survivors there was a higher incidence of bad prognostic factors detected prenatally: pericardial effusion, mitral regurgitation, and cardiomegaly (p < 0.05). The authors suggested a different way of perinatal care and counselling in multiple and single fetal heart tumours. Conclusions: Fetal cardiac tumours in the majority of cases were rhabdomyoma, and in case of normal heart anatomy and normal intracardiac flow the short-term prognosis was good. Fetal single heart tumour with progression of its size in the third trimester may require early surgical resection, so delivery in a tertiary perinatal and cardiac surgery centre might be necessary. Pericardial effusion, mitral regurgitation, and cardiomegaly might implicate a worse prognosis in the case of fetal heart tumour. Fetal cardiac tumour may require a multispecialist team approach to benefit from early detection and diagnosis.

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Fetal cardiac tumor: echocardiography, clinical outcome and genetic analysis in 53 cases

Cited by 48 publications

References 27 publications

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high‐risk fetal tumors: A retrospective single‐center cohort study over 20 years

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high‐risk fetal tumors: A retrospective single‐center cohort study over 20 years

A Multidisciplinary Approach in Prenatal Diagnosis of TSC With Cardiac Rhabdomyoma as the Initial Symptom

Fetal cardiac tumours in a referral prenatal cardiology centre – series of 37 cases with neonatal follow-up

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Fetal cardiac tumor: echocardiography, clinical outcome and genetic analysis in 53 cases

Cited by 48 publications

References 27 publications

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high‐risk fetal tumors: A retrospective single‐center cohort study over 20 years

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high‐risk fetal tumors: A retrospective single‐center cohort study over 20 years

A Multidisciplinary Approach in Prenatal Diagnosis of TSC&nbsp;With Cardiac Rhabdomyoma as the Initial Symptom

Fetal cardiac tumours in a referral prenatal cardiology centre – series of 37 cases with neonatal follow-up

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A Multidisciplinary Approach in Prenatal Diagnosis of TSC With Cardiac Rhabdomyoma as the Initial Symptom