Fetal brain serotonin synthesis and catabolism is under control by mother intake of tryptophan

Arevalo, R.; Afonso, D.; Castro, Rafael; Rodrı́guez, Manuel

doi:10.1016/0024-3205(91)90579-z

Cited by 25 publications

(11 citation statements)

References 44 publications

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“…An increase of serotonin level in placenta has been previously reported 15. We showed that TPH1 mRNA expression was lower in the 2% L-Trp and 5% L-Trp groups than in the control group at E17.5.…”

Section: Discussionsupporting

confidence: 72%

See 1 more Smart Citation

L-Tryptophan Metabolism in Pregnant Mice Fed a High L-Tryptophan Diet and the Effect on Maternal, Placental, and Fetal Growth

Tsuji

Nakata

Sano

et al. 2013

Int J�Tryptophan�Res

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Excess L-tryptophan (L-Trp) in the diet decreases fetal body weight. However, the relationship between L-Trp concentration and its effects on maternal, placental, and fetal growth are not well-understood. We investigated the effects of excess L-Trp intake on maternal, placental, and fetal growth. Female mice were fed a 20% casein diet (control diet) or control diet plus 2% or 5% L-Trp during gestation. Pup weights did not differ between the control (L-Trp intake: 0.04 g/kg body weight (BW)/day) and 2% L-Trp groups (L-Trp intake: 3.3 g/kg BW/day), but were significantly lower in the 5% L-Trp group (L-Trp intake: 7.0 g/kg BW/day) than in the control and 2% L-Trp groups. These results show that less than 3.3 g/kg BW/day L-Trp intake in pregnant mice during gestation does not affect fetal growth or L-Trp homeostasis in the placenta or fetus.

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Section: Discussionsupporting

confidence: 72%

“…In pregnant rodents, fetal body weight was shown to be lower in animals fed a high L-Trp diet compared with rodents fed an normal diet 12,13. However, the relationships between pregnancy and excess L-Trp are not well-documented 12–15…”

Section: Introductionmentioning

confidence: 99%

L-Tryptophan Metabolism in Pregnant Mice Fed a High L-Tryptophan Diet and the Effect on Maternal, Placental, and Fetal Growth

Tsuji

Nakata

Sano

et al. 2013

Int J�Tryptophan�Res

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“…Some silent toxics could even perform their damaging action in prenatal life. The exposure of pregnant animals to neuroactive agents can produce permanent effects in the monoaminergic neurons of the offspring (Alonso et al ., 1991a,b; Arevalo et al ., 1991). The pre- or neo-natal exposure of rats to gram(−) bacteriotoxin lipopolysaccharide (LPS) induces a permanent decrease in the number of DA neurons (Ling et al ., 2002; Carvey et al ., 2003; Fan et al ., 2011a,b; Cai et al ., 2012) and an increase in the α-synuclein aggregation in the surviving DAn (Bandiera et al ., 2011).…”

Section: Aging Silent Toxics and Pdmentioning

confidence: 99%

Parkinson's disease as a result of aging

et al. 2015

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It is generally considered that Parkinson's disease is induced by specific agents that degenerate a clearly defined population of dopaminergic neurons. Data commented in this review suggest that this assumption is not as clear as is often thought and that aging may be critical for Parkinson's disease. Neurons degenerating in Parkinson's disease also degenerate in normal aging, and the different agents involved in the etiology of this illness are also involved in aging. Senescence is a wider phenomenon affecting cells all over the body, whereas Parkinson's disease seems to be restricted to certain brain centers and cell populations. However, reviewed data suggest that Parkinson's disease may be a local expression of aging on cell populations which, by their characteristics (high number of synaptic terminals and mitochondria, unmyelinated axons, etc.), are highly vulnerable to the agents promoting aging. The development of new knowledge about Parkinson's disease could be accelerated if the research on aging and Parkinson's disease were planned together, and the perspective provided by gerontology gains relevance in this field.

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“…Tyrosine (Tyr) and tryptophan (Trp) are well known as two kind of essential amino acids in human and herbivores bodies, the precursors of catecholamine synthesis of adrenalin and serotonin [38,39]. Because they have electrochemical activities, the electroanalysis may be convenient way [40 -43].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Novel Arrays Silver Nanoparticles Modified Polyrutin Coat‐Paraffin‐Impregnated Graphite Electrode for Tyrosine and Tryptophan's Oxidation

2008

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A novel array silver nanoparticles and Rutin complex film modified paraffin-impregnated graphite electrode was proposed in this work (denoted as Ag/Rutin/WGE). The characteristics were investigated by the field emission scanning electron microscopy (FE-SEM), infrared spectra (IR), UV-visible (UV), X-ray photoelectron spectroscopy (XPS) and electrochemical techniques. Silver ions were gradually chelated by polyrutin film at 4'-oxo-5'-OH and 5-OH-4-oxo sites accompanying adsorption, then. Silver nanoparticles were highly-dispersed electrodeposited on polyrutin film. The electrochemical behaviors of tyrosine (Tyr) and tryptophan (Trp) were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The Ag/Rutin/WGE electrode shows overlapping catalysis for the oxidation of Tyr and Trp. The linear response of Tyr and Trp were 0.3 -10.0 and 0.7 -70.0 mM with detection limit of 0.07 and 0.1 mM in a signal-to-noise ratio of 3.

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Fetal brain serotonin synthesis and catabolism is under control by mother intake of tryptophan

Cited by 25 publications

References 44 publications

L-Tryptophan Metabolism in Pregnant Mice Fed a High L-Tryptophan Diet and the Effect on Maternal, Placental, and Fetal Growth

L-Tryptophan Metabolism in Pregnant Mice Fed a High L-Tryptophan Diet and the Effect on Maternal, Placental, and Fetal Growth

Parkinson's disease as a result of aging

Preparation of Novel Arrays Silver Nanoparticles Modified Polyrutin Coat‐Paraffin‐Impregnated Graphite Electrode for Tyrosine and Tryptophan's Oxidation

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